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USP7 leads to the deubiquitination of FOXO1. 2 / 3

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"Moreover, overexpression of Usp7 decreased polyubiquitination of FoxO1, a transcription factor that regulates the transcription of rate-limiting enzymes for gluconeogenesis, including glucose 6-phosphatase catalytic subunit (G6PC) and phosphoenolpyruvate carboxykinase 1 (PCK1) [101]."

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"We also showed that USP7 mediated the deubiquitination of forkhead box protein O1 (FoxO1), while FoxO1 alleviated chondrocyte injury."

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IndraLab

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USP7 leads to the deubiquitination of FOXO1. 2 / 3

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