IndraLab

Statements

USP7 deubiquitinates TPP1. 5 / 6
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"TPP1 Is Deubiquitinated by USP7."
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"Because TPP1 is ubiquitinated and the co-immunoprecipitation data suggested that it is a USP7 substrate, we next tested whether USP7 indeed deubiquitinates TPP1."
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"Together, these data indicate that USP7 deubiquitinates TPP1."
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"Addition of USP7 (WT)-3xFLAG but not USP7 (C223S)-3xFLAG reduced TPP1 ubiquitination (XREF_FIG C, lanes 5 and 6), confirming that TPP1 is a USP7 substrate."
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"Therefore, both in vivo and in vitro evidence indicates that TPP1 is deubiquitinated by USP7."
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