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USP7 deubiquitinates HLTF. 2 / 3
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"Notably, knockdown of USP7 significantly decreased HLTF protein levels and increased HLTF ubiquitination, whereas HLTF did not affect the expression of USP7 protein (Figure 5 M and N)."
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"In particular, USP7 deubiquitinates one of the human orthologs of yeast Rad5, HLTF, and facilitates the poly-ubiquitination of PCNA ( Qing et al., 2011 )."
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