IndraLab

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USP7 deubiquitinates XPC. 5 / 5
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"Other proteins involved in the stabilization of XPC might be the deubiquitylating enzymes OTUD4 and USP7, which were shown to deubiquitylate XPC upon UV induced DNA damage XREF_BIBR XREF_BIBR."
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"Review"
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"Both XPC and CSB also appear to be deubiquitylated by USP7 30, 39, 40 (see below) and regulated by SUMOylation 37, 41, further underscoring the analogies (Figure 2)."
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"Inhibition of USP7 increases XPC ubiquitination level, and without USP7, cells have decreased efficiency in repairing UV lesions [XREF_BIBR, XREF_BIBR]."
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"Specifically, UV induced XPC proteasomal degradation occurs without protection by USP7 which deubiquitinates XPC."
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