IndraLab

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USP7 leads to the deubiquitination of MYC. 3 / 3
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"The results showed that siRNA (si-USP7) or inhibitor (P22077) of USP7 dramatically enhanced c-Myc ubiquitination and decreased c-Myc protein levels (Figure 1J–M), suggesting that USP7-c-Myc may participate in the chemoresistance of liver cancer cells to sorafenib."
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"Furthermore, the expression level of MYH9 can modulate the recruitment of USP7, which mediates the ubiquitination and degradation of c-Myc, ultimately exerting a suppressive effect on EMT signaling and the progression of cancer [86, 87]."
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"Most importantly, we are able to demonstrate that <span class="match term0">USP7</span> deubiquitinates and thereby stabilizes c-<span class="match term1">Myc</span> and that this function is required to maintain neural stem cell fate."
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