IndraLab

Statements


USP7 deubiquitinates IKBKG. 5 / 5
1 | 4

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"Cytoplasmic USP7 binds to and deubiquitinates TRAF6 and IKKgamma, thus terminating TLR mediated NF-kappaB and JNK activation."

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"The aforementioned data demonstrated that both HSCARG and USP7 inhibit NEMO polyubiquitination, and suppression of NEMO polyubiquitination by HSCARG is dependent on USP7."

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"To determine whether USP7 deubiquitinated NEMO polyubiquitination, we examined and compared the levels of NEMO polyubiquitination in HEK 293T cells with or without ectopic USP7."

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"Inhibition of NEMO polyubiquitination by USP7 suggested that USP7 probably inhibited cytokine induced NF-kappaB activation."