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USP7 deubiquitinates ECT2. 4 / 4
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"Co-immunoprecipitation, immunofluorescent stainings, in vivo deubiquitination and in vitro deubiquitination experiments were performed to examine the physical and functional interaction between <span class="match term1">ECT2</span> and ubiquitin-specific protease <span class="match term0">USP7</span>"
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"Given that ECT2 is an ubiquitinated protein XREF_BIBR, XREF_BIBR and USP7 promotes the stabilization of ECT2, we next asked the question whether USP7 functions to deubiquitinate ECT2."
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"Specifically, we uncovered that ECT2 and USP7 form a positive feedback loop, in which ECT2 promotes USP7 intermolecular self association, -deubiquitination and -stabilization, and reciprocally, USP7 deubiquitinates and stabilizes ECT2."
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"USP7 in turn, deubiquitinates and stabilizes ECT2, resulting in a feedforward regulatory circuit that ultimately sustains the expression of oncogenic protein MDM2."
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