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USP7 deubiquitinates PCNA. 12 / 13
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"Suppression of USP7 increased H 2 O 2 -induced PCNA mono-ubiquitination not only in WI38VA13 cells but also in the other cell lines tested ( Figures S1 F and S1G), and also in HeLa cells (as shown lat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Whereas Rad6/Rad18 E2 conjugate/E3 ligase cause PCNA monoubiquitination, Usp1 and Usp7 cause PCNA deubiquitination with some difference in case of HU (Niimi et al, 2008; Fox et al, 2011)."
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"However, suppression of USP7 and also USP1 clearly increased H 2 O 2 -induced PCNA mono-ubiquitination, indicating that some fraction of these enzymes is still active in H 2 O 2 -treated cells and cap[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The increase in H 2 O 2 -induced mono-ubiquitination following USP7 suppression was not observed in cells expressing hemagglutinin (HA)-tagged PCNA mutated at K164R ( Figure 2 C), and H 2 O 2 -induced[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Kashiwaba et al. have additionally shown that USP7 can deubiquitylate PCNA, but this is not coupled to DNA replication and likely plays a role in DNA repair."
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"We focused on USP7 and USP11 among ATAD5-N bound USPs, because it was reported that USP7 deubiquitinates Ub–PCNA and that USP11 binds to USP7."
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"USP7 can deubiquitinate both PCNA [78] and RAD18 [76] , the E3 Ub ligase responsible for this ubiquitination [79] ."
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"In contrast to USP1 suppression, suppression of USP7 promoted H 2 O 2 -induced mono-ubiquitination of PCNA at all three time points relative to control cells ( Figure 3 D; compare lanes 10–12 with lan[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP7 can deubiquitinate PCNA alongside a related DUB, USP1."
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"Surprisingly, USP7 also deubiquitylates PCNA."
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"On the other hand, the suppression of USP7 gene expression simply increased the level of PCNA mono-ubiquitination without altering the kinetic profile at which mono-ubiquitinated PCNA is produced; the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In the case of USP7, ATAD5 (1 to 603) enhanced the USP7-mediated poly-Ub–PCNA deubiquitination (Fig. 6I and SI Appendix, Fig. S6Y)."
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