IndraLab

Statements


USP7 deubiquitinates USP7. 5 / 5
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"However, HAUSP also deubiquitinates MDM2 and reduction of HAUSP levels, either by RNA interference or by gene deletion, produces a complex phenotype [XREF_BIBR - XREF_BIBR]."

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"The ectopic expression of PRMT5 interacts with G3BP2, G3BP2 in turn deubiquitination and stabilization by USP7, and then recruitment of methy-G3BP2-PRMT5-USP7 complex to lipogenic gene promoters, thereby activating lipogenesis and tumorigenesis."

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"Previous studies have shown that deubiquitinates Recombinant Ubiquitin Specific Peptidase 7 (USP7) and USP44 can regulate FOXP3 stability (54, 55)."

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"We also found that SIRT7 enzymatic activity is negatively regulated by ubiquitin-specific-processing protease 7 (USP7)-mediated deubiquitination, which helps control gluconeogenesis by regulating G6PC expression (45)."

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"In addition, utilizing the UbiTest analysis we demonstrate that inhibition of USP7 increases polyubiquitination of Foxp3, Tip60 and USP7."