IndraLab

Statements

USP7 deubiquitinates USP7. 3 / 3
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"In addition, utilizing the UbiTest analysis we demonstrate that inhibition of USP7 increases polyubiquitination of Foxp3, Tip60 and USP7."
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"However, HAUSP also deubiquitinates MDM2 and reduction of HAUSP levels, either by RNA interference or by gene deletion, produces a complex phenotype [XREF_BIBR - XREF_BIBR]."
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"We also found that SIRT7 enzymatic activity is negatively regulated by ubiquitin-specific-processing protease 7 (USP7)-mediated deubiquitination, which helps control gluconeogenesis by regulating G6PC expression (45)."
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