IndraLab

Statements

USP7 leads to the deubiquitination of AXIN. 6 / 6
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"USP7 promotes deubiquitination and stabilization of Axin."
31519875
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"Coexpression of USP7 suppressed either RNF146 or SIAH1-induced poly-ubiquitination of Axin (Supplementary Fig. 3d)."
31519875
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"Deubiquitination of Axin mediated by USP7 prevents Axin from degrading and providing stability."
32486158
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"Lei Ji et al. showed that USP7 inhibited Wnt/β-catenin by interacting with Axin TRAF domains and promoting the de-ubiquitination and stabilization of Axin 28."
34539900
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"These results suggest that polyubiquitinated Axin1, but not β-catenin, is an efficient substrate of USP7.Since USP7 knockout promotes Wnt-induced Axin degradation (Fig. 3d, e), we next examined whether USP7 knockout affects Wnt-induced Axin ubiquitination."
31519875
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"USP7 directly interacts with Axin through its TRAF domain, and promotes deubiquitination and stabilization of Axin."
31519875