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USP7 deubiquitinates FBP1. 4 / 4
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"Moreover, we revealed that ubiquitin carboxyl-terminal hydrolase 7 (USP7) binds to and induces the deubiquitination of FBP1, which prevented FBP1 from translocating to the nucleus."
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"USP7 can also deubiquitinate and block the nuclear localization of FBP1, which is responsible for increasing the sensitivity of PARP inhibitors by interacting with DNMT1 and trapping PARP1 in chromatin (Cheng et al., 2022)."
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"In addition, ubiquitin carboxyl-terminal hydrolase 7 (USP7) binds to and deubiquitinates FBP1, which prevents FBP1 from translocating to the nucleus [21]."
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"Deubiquitination of FBP1 by USP7 blocks FBP1-DNMT1 interaction and decreases the sensitivity of pancreatic cancer cells to PARP inhibitors."
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