IndraLab

Statements

USP7 leads to the deubiquitination of PHF8. 4 / 4
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"For instance, USP7 promotes the deubiquitination and stabilization of PHF8 [13]."
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"showed that USP7 promotes deubiquitination and stabilization of PHF8 in breast cancer MCF7 cells, accounting for a mechanism underlying PHF8 deregulation."
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"Here, we report that PHF8 physically associates with the deubiquitinase USP7."
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"Specifically, we demonstrated that USP7 promotes deubiquitination and stabilization of PHF8, leading to the upregulation of a group of genes, including cyclin A2, that are critical for cell growth and proliferation."
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