IndraLab

Statements

USP7 deubiquitinates PHF8. 5 / 6
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"USP7 deubiquitinates histone demethylases PHF8 and LSD1 as well as the histone methyltransferase MLL5 ( Wang et al., 2016 ; Yi et al., 2016 ; Ding et al., 2015 )."
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"showed that USP7 promotes deubiquitination and stabilization of PHF8 in breast cancer MCF7 cells, accounting for a mechanism underlying PHF8 deregulation."
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"For instance, USP7 promotes the deubiquitination and stabilization of PHF8 [13]."
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"USP7 promotes deubiquitination and stabilization of PHF8, leading to the upregulation of genes, including cell cycle factor cyclin A2."
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"Specifically, we demonstrated that USP7 promotes deubiquitination and stabilization of PHF8, leading to the upregulation of a group of genes, including cyclin A2, that are critical for cell growth and proliferation."
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