IndraLab

Statements

Modified USP7 leads to the deubiquitination of REST. 4 / 4
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"Moreover, deubiquitination assay demonstrated that expression of Wt-HAUSP but not the Mt-HAUSP attenuated the REST ubiquitination induced by B5 shHAUSP (XREF_FIG), showing that Wt-HAUSP functioned through deubiquitination to stabilize REST and rescued the differentiation phenotype induced by knockdown of endogenous HAUSP."
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"Importantly, overexpression of HAUSP with beta-TrCP together abolished the increased REST ubiquitination induced by beta-TrCP overexpression (XREF_SUPPLEMENTARY, lanes 4, 3)."
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"Consistently, expression of HAUSP reduced REST poly-ubiquitination (XREF_SUPPLEMENTARY, lanes 2, 1), and overexpression of beta-TrCP increased REST ubiquitination (XREF_SUPPLEMENTARY, lanes 3, 2)."
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"Ectopic expression of Wt-HAUSP but not the Mt-HAUSP decreased REST ubiquitination and increased REST protein levels (XREF_FIG; XREF_SUPPLEMENTARY)."
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