IndraLab

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OTUD7B affects ZAP70
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OTUD7B binds ZAP70.
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ZAP70 binds OTUD7B. 10 / 11
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"Domain mapping analyses revealed the requirement of the N-terminal UBA domain of Otud7b for its physical interaction with Zap70 ( xref ), indicating the facilitation of Otud7b–Zap70 interaction by ubiquitination."
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"Otud7b binds to and deubiquitinates Zap70."
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"In response to TCR signaling, Otud7b was rapidly recruited to Zap70 via a mechanism that required the UBA domain of Otud7b, suggesting the possibility that Otud7b interacted with ubiquitinated Zap70."
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"Interestingly, although Otud7b did not bind Zap70 in resting T cells, these two proteins formed a complex upon TCR–CD28 stimulation ( xref )."
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"Upon TCR stimulation, OTUD7B binds to and deubiquitinates Zap70, thereby preventing the binding of Sts1 and 2 [ xref ]."
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"Otud7b binds to and deubiquitinates Zap70, thereby preventing the interaction of Zap70 with the negative-regulatory phosphatases, Sts1 and Sts2 199 (XREF_FIG)."
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"In response to TCR–CD28 ligation, Otud7b rapidly bound to Zap70 and inhibited Zap70 ubiquitination."
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"In response to TCR-CD28 ligation, Otud7b rapidly bound to Zap70 and inhibited Zap70 ubiquitination."
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"This ubiquitination-defective Zap70 mutant was also attenuated in association with Otud7b, consistent with the idea that the Zap70–Otud7b interaction might be facilitated by Zap70 ubiquitination ( xref )."
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"The Otud7b–Zap70 interaction was further confirmed using a transient transfection experiment in which the overexpressed Otud7b strongly associated with Zap70 ( xref )."
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USP9X binds ZAP70 and OTUD7B. 1 / 1
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"Unlike Otud7b, USP9X does not directly interact with Zap70 but rather comes into the proximity of Zap70 via interaction with a LAT signaling complex [ xref ]."
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ZAP70 binds OTUD7B and Sts1/2. 1 / 1
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"Collectively, these data suggest that the enhanced interaction between Zap70 and Sts1/2 in Otud7b-deficient T cells contributes to attenuated Zap70 activation and TCR signaling."
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OTUD7B deubiquitinates ZAP70.
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OTUD7B deubiquitinates ZAP70. 6 / 6
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"OTUD7B has been shown to antagonize ZAP70 ubiquitination, which prevents association with STS1 and STS2."
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"Otud7b binds to and deubiquitinates Zap70."
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"Importantly, the Otud7b deficiency substantially enhanced the ubiquitination of Zap70 (XREF_FIG), and the Otud7b knockdown in EL4 cells also enhanced the TCR-CD28-stimulated Zap70 ubiquitination (XREF_FIG)."
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"Otud7b binds to and deubiquitinates Zap70, thereby preventing the interaction of Zap70 with the negative-regulatory phosphatases, Sts1 and Sts2 199 (XREF_FIG)."
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"86 A DUB, Otud7b, deubiquitinates ZAP70 to prevent its association with Sts1 and Sts2, thereby positively regulating TCR signaling."
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"Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination"
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OTUD7B deubiquitinates ZAP70 on K544. 2 / 2
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"Mechanistically, Otud7b deubiquitinated Zap70 at K544."
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"Otud7b likely opposes the action of a Zap70 E3 ligase other than Nrdp1, because Otud7b inhibits Zap70 ubiquitination mainly at K544, which differs from the Nrdp1 target site (K538)."
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OTUD7B inhibits ZAP70.
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OTUD7B inhibits ZAP70. 3 / 3
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"Otud7b deficiency attenuates the activation of Zap70 and its downstream pathways and impairs T cell activation and differentiation, rendering mice refractory to T cell mediated autoimmune and inflammatory responses."
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"Otud7b knockdown in EL4 cells also enhanced the inducible association of Zap70 with Sts1/2 (XREF_FIG)."
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"Otud7b deficiency attenuated TCR-CD28-stimulated activation of Zap70 and downstream signaling factors and impaired T cell activation and Th1 cell differentiation."
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OTUD7B bound to ZAP70 inhibits ZAP70. 1 / 1
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"Otud7b binds to and deubiquitinates Zap70, thereby preventing the interaction of Zap70 with the negative-regulatory phosphatases, Sts1 and Sts2 199 (XREF_FIG)."
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OTUD7B dephosphorylates ZAP70.
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OTUD7B leads to the dephosphorylation of ZAP70. 4 / 4
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"Otud7b deficiency inhibited TCR-CD28-stimulated phosphorylation of Zap70, Akt, and Erks in both naive CD4 + T cells (XREF_FIG) and naive CD8 + T cells (XREF_FIG)."
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"As seen in primary T cells, Otud7b knockdown by shRNA profoundly inhibited the TCR-CD28-stimulated phosphorylation of Zap70, as well as several downstream kinases (XREF_FIG)."
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"Because Otud7b deficiency attenuated Zap70 phosphorylation without affecting activation of its upstream kinase Lck, we hypothesized that the enhanced Zap70 ubiquitination in Otud7b -/- T cells might promote the recruitment of a negative regulator to reduce the phosphorylation of Zap70."
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"This possibility is further suggested by our present finding that Otud7b deficiency promotes Zap70 ubiquitination and inhibits Zap70 phosphorylation in both CD4 + and CD8 + T cells."
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OTUD7B ubiquitinates ZAP70.
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OTUD7B leads to the ubiquitination of ZAP70. 3 / 3
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"We further demonstrated that by deubiquitinating Zap70, Otud7b prevented the association of Zap70 with the phosphatase Sts1/2, thereby facilitating Zap70 phosphorylation and TCR signaling."
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"Importantly, the Otud7b deficiency substantially enhanced the ubiquitination of Zap70 (XREF_FIG), and the Otud7b knockdown in EL4 cells also enhanced the TCR-CD28-stimulated Zap70 ubiquitination (XREF_FIG)."
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"This possibility is further suggested by our present finding that Otud7b deficiency promotes Zap70 ubiquitination and inhibits Zap70 phosphorylation in both CD4 + and CD8 + T cells."
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OTUD7B phosphorylates ZAP70.
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OTUD7B leads to the phosphorylation of ZAP70. 2 / 2
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"The aforementioned results suggested that Otud7b might promote Zap70 phosphorylation by limiting its binding by the phosphatases Sts1/2."
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"The aforementioned results suggested that Otud7b might promote Zap70 phosphorylation by limiting its binding by the phosphatases Sts1/2."
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OTUD7B activates ZAP70.
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OTUD7B activates ZAP70. 2 / 2
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"Because of the crucial role of Otud7b in regulating the phosphorylation of Zap70, but not Lck, we examined whether Otud7b directly targeted Zap70."
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"Otud7b deficiency promotes the association of Zap70 with Sts1/2."
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OTUD7B affects KDM1A
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OTUD7B binds KDM1A.
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OTUD7B binds KDM1A. 10 / 14
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"Taken all together, these results suggest that OTUD7B binds and stabilizes LSD1 via abrogating its ubiquitination‐dependent proteasomal degradation.2.2 OTUD7B Is a Bona Fide LSD1 Deubiquitinase."
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"In addition to USP22 and USP28, ectopic OTUD7B also bound robustly to endogenous LSD1 (Figure  1A )."
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"Using OLco‐regulated gene sets revealed that loss of OTUD7B or LSD1 resulted in a significantly reduced expression of metastatic genes (Figure xref , Supporting Information), providing potential mechanistic clues explaining suppressed metastatic ability due to impaired OTUD7B–LSD1 signaling."
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"Of note, both wild type (WT) and the catalytically inactive form (CI, C194A/H358R) of OTUD7B bound ectopic LSD1 (Figure S1C,D, Supporting Information)."
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"Taken all together, these results suggest that OTUD7B binds and stabilizes LSD1 via abrogating its ubiquitination‐dependent proteasomal degradation."
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"2.1 OTUD7B Binds LSD1 and Regulates Its Stability."
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"Interestingly, when compared to LSD1–CoREST complex, endogenous OTUD7B–LSD1 complex is readily detectable but with much less abundance, indicating OTUD7B may interact with LSD1 in a transient manner (Figure 1B)."
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"Therefore, perturbation of OTUD7B–LSD1 axis results in changes in both activating and repressive chromatin modification marks, providing a plausible mechanism for altered gene transcription due to OTUD7B loss."
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"In addition to USP22 and USP28, ectopic OTUD7B also bound robustly to endogenous LSD1 ( Figure   xref )."
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"OTUD7B Binds LSD1 and Regulates Its Stability."
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OTUD7B deubiquitinates KDM1A.
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OTUD7B deubiquitinates KDM1A. 5 / 5
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"Conversely, OTUD7B depletion remarkably enhanced polyubiquitination of endogenous LSD1 (Figure 2B)."
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"To assess the types of Ub‐linkage that OTUD7B may catalyze when deubiquitinates LSD1, we utilized two Ub mutants, K48 and K63."
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"OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis."
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"Therefore, perturbation of OTUD7B–LSD1 axis results in changes in both activating and repressive chromatin modification marks, providing a plausible mechanism for altered gene transcription due to OTUD7B loss.To investigate the contribution of LSD1 deubiquitination by OTUD7B in OTUD7B‐mediated LSD1 genomic distribution and H3K4me2/H3K9me2 enrichment, we analyzed LSD1 binding and H3K4me2/H3K9me2 levels of the selected 11 genes in LSD1 reconstituting cells."
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"As shown in Figure S3A in the Supporting Information, K63R mutation caused significant loss of polyubiquitinated LSD1 signals, whereas K48R displayed very marginal reduction in LSD1 ubiquitination, suggesting LSD1 ubiquitination involves mixed linkage specificity, and predominantly prefers K63‐linked polyubiquitin chains.We next determined whether OTUD7B modulated LSD1 deubiquitination."
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OTUD7B leads to the deubiquitination of KDM1A on K63. 1 / 1
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"OTUD7B deficiency increases K63-linked ubiquitination of LSD1, which disrupts LSD1/CoREST complex formation and targets LSD1 for p62-mediated proteolysis."
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OTUD7B activates KDM1A.
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OTUD7B activates KDM1A. 4 / 4
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"Moreover, physiological fluctuation of OTUD7B modulates cell cycle-dependent LSD1 oscillation, ensuring the G1/S transition."
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"We first asked if CoREST is required for OTUD7B‐mediated LSD1 stabilization."
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"The fact that many of these gene hits are linked to cell cycle likely explains the result that the primary functions of OTUD7B or LSD1 in coordinating cell cycle progression.The above ChIP‐seq and RNA‐seq datasets were aligned to explore the potential correlations between OTUD7B‐induced H3K4me2 and LSD1 occupancy changes and changes in gene transcription."
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"19 Strikingly, p62 knockdown completely blunted LSD1 degradation triggered by OTUD7B or CoREST loss (Figure  4A ,B)."
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OTUD7B ubiquitinates KDM1A.
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OTUD7B leads to the ubiquitination of KDM1A. 2 / 2
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"In cells expressing K63R Ub mutant, OTUD7B‐depletion failed to increase LSD1 ubiquitination (Figure 2C)."
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"Collectively, these results demonstrate that K63‐linked ubiquitination of LSD1, triggered by depletion of OTUD7B or CoREST, targets LSD1 to proteasomal degradation via p62.The enhanced interaction between p62 and LSD1 upon OTUD7B loss raised one possibility that p62 may compete with CoREST for binding to ubiquitinated LSD1."
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OTUD7B leads to the ubiquitination of KDM1A on K63. 1 / 1
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"OTUD7B deficiency increases K63 linked ubiquitination of LSD1, which disrupts LSD1 and CoREST complex formation and targets LSD1 for p62 mediated proteolysis."
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OTUD7B inhibits KDM1A.
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OTUD7B inhibits KDM1A. 2 / 2
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"We next generated OTUD7B reconstituting cell lines by expressing sgRNA‐resistant WT or mutant OTUD7B construct in MDA‐MB‐231 cells depleted of OTUD7B, and found only WT OTUD7B reconstitution rescued LSD1 decrease, excluding a possible off‐target issue during sgRNA‐mediated knockdown, also suggesting the DUB catalytic function of OTUD7B is required for its regulation of LSD1 (Figure 1F)."
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"OTUD7B or CoREST depletion only resulted in LSD1 degradation in p62 cells, but not in p62 cells (Figure 4E), suggesting that the binding to poly‐Ub chains on LSD1 is indispensable for p62‐mediated LSD1 degradation triggered by the deficiency of OTUD7B or CoREST.We next determined the type of poly‐Ub chains predisposed LSD1 to p62 binding."
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OTUD7B increases the amount of KDM1A.
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OTUD7B increases the amount of KDM1A. 1 / 1
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"As described earlier, in OTUD7B‐dificient cells, WT OTUD7B reconstitution fully restored LSD1 protein expression."
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OTUD7B decreases the amount of KDM1A.
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OTUD7B decreases the amount of KDM1A. 1 / 1
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"Conversely, OTUD7B depletion in several breast cancer cell lines profoundly decreased LSD1 protein level, without affecting LSD1 mRNA expression (Figure 1E)."
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OTUD7B affects TRAF3
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OTUD7B binds TRAF3.
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TRAF3 binds OTUD7B. 8 / 8
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"In response to noncanonical NF-kappaB stimuli, Otud7b binds and deubiquitinates TRAF3, thereby inhibiting TRAF3 proteolysis and preventing aberrant noncanonical NF-kappaB activation."
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"Non-canonical NF-κB activators induce the interaction of OTUD7B and TRAF3, thereby down-regulating TRAF3 ubiquitination and degradation and preventing aberrant non-canonical NF-κB activation."
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"Notably, OTUD7B directly binds to TRAF3 rather than to NIK and deubiquitinates TRAF3, thereby inhibiting TRAF3 proteolysis and preventing NIK accumulation and NF-κB pathway activation."
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"We found that Traf3 physically interacted with Otud7b in T cells (unpublished data), although we could not detect appreciable degradation of Traf3 along with TCR-CD28 ligation in either WT or Otud7b deficient T cells."
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"Non-canonical NF-κB activators induce the interaction of OTUD7B and TRAF3, thereby down-regulating TRAF3 ubiquitination and degradation and preventing aberrant non-canonical NF-κB activation."
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"We found that Traf3 physically interacted with Otud7b in T cells (unpublished data), although we could not detect appreciable degradation of Traf3 along with TCR–CD28 ligation in either WT or Otud7b-deficient T cells."
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"Upon ligation of these receptors, Otud7b binds to TRAF3, and this inducible interaction requires a ubiquitin association (UBA) domain present in the N-terminus of Otud7b, suggesting the possibility that ubiquitination of TRAF3 may facilitate its binding by Otud7b."
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"Activation of BAFFR increases OTUD7B expression and the newly synthesized deubiquitinase then binds to TRAF3 resulting in the formation of a high molecular weight complex including OTUDB7, TRAF3, TRAF2, and cIAP1/2."
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TRAF3 binds OTUD7B and MAP3K14. 1 / 1
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"Reciprocal co-immunoprecipitation was performed using anti-Flag anti-Myc and anti-HA antibodies to confirm whether OTUD7B directly binds to NIK or TRAF3."
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OTUD7B activates TRAF3.
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OTUD7B activates TRAF3. 6 / 8
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"In addition to being transcriptionally upregulated by NF-kappaB to promote NIK degradation, leading to p100 stabilization and attenuation of non canonical NF-kappaB signalling, TRAF3 is subject to post-translational stabilisation by means of OTUD7B, which targets TRAF3 for deubiquitination of its K48 linked polyubiquitin chains, thereby preventing NIK accumulation and the processing of p100 [XREF_BIBR, XREF_BIBR]."
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"Otud7b inhibits ubiquitin dependent Traf3 degradation in B cells stimulated through TNF receptor family members, such as BAFF receptor and CD40, and, thereby, negatively regulates noncanonical NF-kappaB signaling and B cell activation."
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"Interestingly , we discovered that OTUD7B increases TRAF3 and decreases NIK to inhibit the non-canonical NF-kappaB pathway and that overexpression of OTUD7B suppresses LCL161-induced cell invasion and migration ."
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"Although the OTU domain of Otud7b preferentially cleaves K11 linked ubiquitin chains in vitro, the Otud7b deficiency in vivo promotes TRAF3 conjugation with K48 ubiquitin chains."
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"OTUD7B increased expression of TRAF3 , leading to a decrease in NIK and processing of p100 to p52 compared to those in the empty vector group ( Fig. 4c ) ."
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"Likely candidate genes include those encoding TRAF2, TRAF3, the cIAPs or OTUD7B, a de-ubiquitinase that promotes TRAF3 stability."
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OTUD7B deubiquitinates TRAF3.
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OTUD7B deubiquitinates TRAF3. 3 / 3
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"OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3"
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"In response to noncanonical NF-kappaB stimuli, Otud7b binds and deubiquitinates TRAF3, thereby inhibiting TRAF3 proteolysis and preventing aberrant noncanonical NF-kappaB activation."
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"OTUD7B suppresses Smac mimetic-induced lung cancer cell invasion and migration via deubiquitinating TRAF3."
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OTUD7B-C194S deubiquitinates TRAF3. 1 / 1
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"The Otud7b mediated TRAF3 deubiquitination required its DUB activity since a catalytically inactive Otud7b mutant, C194S and H358R (CH), failed to deubiquitinate TRAF3 (XREF_FIG)."
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Modified OTUD7B leads to the deubiquitination of TRAF3. 1 / 1
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"The loss of Otud7b promoted anti-CD40-stimulated TRAF3 ubiquitination (XREF_FIG)."
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OTUD7B-H358R deubiquitinates TRAF3. 1 / 1
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"The Otud7b mediated TRAF3 deubiquitination required its DUB activity since a catalytically inactive Otud7b mutant, C194S and H358R (CH), failed to deubiquitinate TRAF3 (XREF_FIG)."
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Mutated OTUD7B deubiquitinates TRAF3. 1 / 1
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"The Otud7b mediated TRAF3 deubiquitination required its DUB activity since a catalytically inactive Otud7b mutant, C194S and H358R (CH), failed to deubiquitinate TRAF3 (XREF_FIG)."
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OTUD7B inhibits TRAF3.
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"We transfected HA-OTUD7B ( WT ) and HA-OTUD7B ( CH ) into H1299 cells and found that OTUD7B ( CH ) decreased the expression of TRAF3 and led to an increase in NIK and processing of p100 to p52 compared to that in the OTUD7B ( WT ) cells ( Fig. 6b ) ."
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"Because Traf3 deficiency also attenuates TCR signaling, we examined whether Otud7b deficiency promoted the degradation of Traf3 in T cells."
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"The de-ubiquitinating enzyme OTUD7B was also shown recently to potentially negatively regulate NF-kappaB2 (and primary B cell activation) by inhibiting activation induced degradation of TRAF3."
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OTUD7B ubiquitinates TRAF3.
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OTUD7B ubiquitinates TRAF3. 1 / 1
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"The loss of Otud7b promoted anti-CD40-stimulated TRAF3 ubiquitination ( xref )."
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OTUD7B affects NFkappaB
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OTUD7B inhibits NFkappaB.
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OTUD7B inhibits NFkappaB. 10 / 13
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"In B cells, Otud7b suppresses the activation of noncanonical NF-kappaB signaling by deubiquitinating and stabilizing a negative regulator, TRAF3 201."
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"Moreover, Overexpression of OTUD7B or TNIP2 indeed antagonizes miR-1180-induced NF-kappaB activation, which further confirmed our conclusion that miR-1180-regulating OTUD7B (or TNIP2) - NF-kappaB- signaling regulation mediates HCC resistance (XREF_FIG and XREF_SUPPLEMENTARY)."
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"Loss of Cezanne increased transcriptional activity of NF-kappaB (Supplementary Fig S1E) as shown before XREF_BIBR, and also of p53 (Supplementary Fig S1F), suggesting that Cezanne can act as a positive and a negative regulator of transcription factors."
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"Recent studies have suggested that OTUD7B (also known as Cezanne) negatively regulates signal induced noncanonical NF-kappaB pathway activation by deubiquitylating TRAF3."
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"Moreover, OTUD7B negatively regulated NF-kappaB signaling pathway, which may be an effective target for antitumor therapy for HCC."
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"Cezanne is induced by TNF stimulation and inhibits NF-κB in a negative feedback loop ( xref )."
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"Previous studies have shown that OTUD7B inhibited NF-kappaB pathway by deconjugating K63-polyubiquitin chains from RIP-1 and TRAF6, suggesting that it may have roles in inhibition of cancer progression XREF_BIBR, XREF_BIBR."
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"Consistently, the WT Otud7b, but not Otud7b CH, suppressed the activation of noncanonical NF-kappaB signaling (XREF_FIG)."
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"Thus although hypoxia primed cells for inflammatory activation it simultaneously induced Cezanne which impeded signalling to NF-kappaB by suppressing TRAF6 ubiquitination ."
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"For example, the deubiquitinases Gumby (OTULIN), OTUD7b, and TNFAIP3 (A20) in the OUT family were shown to negatively regulate NFkappaB activation through different mechanisms in different biological contexts [XREF_BIBR - XREF_BIBR]."
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OTUD7B activates NFkappaB.
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"The Otud7b deficiency greatly enhanced the NF-kappaB activation by agonistic anti-LTbetaR and anti-CD40 antibodies or BAFF (XREF_FIG), a result that was not due to differential expression of the receptors (XREF_SUPPLEMENTARY)."
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"This study sheds light on the molecular mechanism of negative regulation of NF-κB activation by Cezanne."
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"Mutation at these sites disrupted the recruitment of Cezanne to activated TNFR complex and dramatically reduced the inhibition of NF-κB activation by Cezanne."
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"Other proteins that modulate NFkappaB signaling were also downregulated, including ubiquitin conjugating enzyme E2 V1 (UBE2V1), which activates NFkappaB, and OTU deubiquitinase 7B (OTUD7B), a clock regulated protein that downregulates the non canonical NF-kappaB pathway."
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"Otud7b deficiency in mice has no appreciable effect on canonical NF-kappaB activation but causes hyper-activation of noncanonical NF-kappaB."
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OTUD7B deubiquitinates NFkappaB.
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"OTUD7B, a newly identified member of the A20 family of DUBs, inhibits RIP1 ubiquitination and downstream IKK activity and NF-kappaB signalling [XREF_BIBR]."
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Sal-miR-1 affects OTUD7B
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Sal-miR-1 inhibits OTUD7B.
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"Sal-miR-1 and 3 abrogate OTUD7B upregulation by thrombin via targeting the OTUD7B 3 ' UTR."
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"Most importantly , OTUD7B downregulation by Sal-miR-1 and 3 attenuates KLF4 protein levels via decreasing its deubiquitylation , whereas decreased KLF4 relieves its repression of transcription of NMHC IIA gene and thus increases NMHC IIA expression levels ."
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"Mechanistically, Sal-miR-1 and 3 abrogate OTUD7B upregulation by thrombin via binding to the different sites of the OTUD7B 3 ' UTR."
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"Sal-miR-1 and 3 abrogate OTUD7B upregulation by thrombin via targeting the OTUD7B 3'UTR Because plant-derived miRNAs are known to be capable of regulating mammalian gene expression by binding to the 3 ' UTR of target genes 19 , 29 , we utilized the bioinformatic databases miRanda ( http://www.microrna.org/microrna/home.do ) , Targetscan ( http://www.targetscan.org/vert_72/ ) and RNAhybrid ( https://bibiserv.cebitec.uni-bielefeld.de/rnahybrid/ ) to predict Sal-miR-1 and 3 targets ( Figure S3A , Table S1 ) ."
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"OTUD7B downregulation by Sal-miR-1 and 3 attenuates KLF4 protein levels To clarify which substrate is regulated and deubiquitinated by OTUD7B in the context of VSMC migration and adhesion , we used 3 protein-protein interaction prediction databases ( Cytoscape : http://apps.cytoscape.org/apps/agilentliteraturesearch; inBio-Map : https://www.intomics.com/inbio/map.html#search; Genemania : http://genemania.org ) to search for putative proteins interacting with OTUD7B ."
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"Mechanistically , Sal-miR-1 and 3 abrogate OTUD7B upregulation by thrombin via binding to the different sites of the OTUD7B 3'UTR ."
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"We show here that OTUB7B upregulates the level of KLF4 protein , a stem cell pluripotency protein 41 , through interacting with and deubiquitylating KLF4 , a repressor of VSMC differentiation , whereas OTUD7B downregulation by Sal-miR-1 and 3 attenuates KLF4 protein level ."
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"Results of luciferase reporter assays using OTUD7B 3'UTR or its mutant plasmids demonstrated that Sal-miR-1 and 3 could target the 3'UTR of OTUD7B mRNA and then inhibited OTUD7B expression ."
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"Importantly , OTUD7B downregulation by Sal-miR-1 and 3 results in a reduction in KLF4 protein level , which in turn relieves KLF4 repression of the expression of SM alpha-actin , SM22alpha , and SMMHC , thus facilitating VSMC contractile gene ( VSMC differentiation gene ) expression ."
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"In this study, our results showed that Sal-miR-1 and 3 reduced the upregulation of the OTUD7B mRNA and protein induced by thrombin."
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Sal-miR-1 decreases the amount of OTUD7B.
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"Sal-miR-1 and Sal-miR-1 obviously decreased the expression of OTUD7B and intimal hyperplasia induced by vascular injury, suggesting that OTUD7B plays the pro inflammatory and pro proliferation effects for VSMCs in response to vascular injury."
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"Next, we confirmed that Sal-miR-1 or Sal-miR-3 alone or together significantly inhibited the expression of OTUD7B mRNA and protein, but did not affect KLF3 and KLF10 expression, indicating the specificity of these two miRNA target recognition (XREF_SUPPLEMENTARY B-C)."
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"Remarkably, Sal-miR-1 and 3 increased the expression levels of NMHC IIA by inhibiting OTUD7B expression and thus reducing KLF4 protein levels."
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Sal-miR-1 activates OTUD7B.
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"Considering that KLF4 is a transcription factor required for VSMC phenotype switching, and its stability is regulated by ubiquitination mediated protein degradation, it is reasoned that OTUD7B downregulation induced by Sal-miR-1 and 3 resulted in a decrease in KLF4 protein levels."
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"Results of luciferase reporter assays using OTUD7B 3 ' UTR or its mutant plasmids demonstrated that Sal-miR-1 and 3 could target the 3 ' UTR of OTUD7B mRNA and then inhibited OTUD7B expression."
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OTUD7B affects KLF4
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OTUD7B decreases the amount of KLF4.
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| 3
reach
"OTUD7B downregulation by Sal-miR-1 and 3 attenuates KLF4 protein levels."
32685020
reach
"We show here that OTUB7B upregulates the level of KLF4 protein, a stem cell pluripotency protein XREF_BIBR, through interacting with and deubiquitylating KLF4, a repressor of VSMC differentiation, whereas OTUD7B downregulation by Sal-miR-1 and 3 attenuates KLF4 protein level."
32685020
reach
"Most importantly, OTUD7B downregulation by Sal-miR-1 and 3 attenuates KLF4 protein levels via decreasing its deubiquitylation, whereas decreased KLF4 relieves its repression of transcription of NMHC IIA gene and thus increases NMHC IIA expression levels."
32685020
OTUD7B binds KLF4.
| 1 2
OTUD7B binds KLF4. 3 / 3
| 1 2
sparser
"The specificity of their interaction was verified by increased association of OTUD7B with KLF4 in OTUD7B-overexpressed cells (Figure xref G)."
32685020
sparser
"In the further study, we utilized co-immunoprecipitation experiments to examine the interaction of OTUD7B with KLF4 and found that KLF4 was co-immunoprecipitated by anti-OTUD7B antibody."
32685020
reach
"As anticipated, co-immunoprecipitation experiments revealed that OTUD7B interacted with and deubiquitylated KLF4."
32685020
OTUD7B activates KLF4.
| 3
OTUD7B activates KLF4. 3 / 3
| 3
reach
"Consistently, in HEK293 cells and VSMCs enforced to express OTUD7B and KLF4, OTUD7B overexpression obviously enhanced KLF4 protein stability."
32685020
reach
"Correspondingly, OTUD7B knockdown decreased, whereas its overexpression increased, KLF4 protein levels."
32685020
reach
"Our findings reveal, for the first time, that OTUD7B upregulates the level of KLF4 protein through interacting with and deubiquitylating KLF4."
32685020
OTUD7B deubiquitinates KLF4.
| 2
OTUD7B deubiquitinates KLF4. 2 / 2
| 2
reach
"These data indicated that OTUD7B interacts with and deubiquitylates KLF4 and OTUD7B downregulation by Sal-miR-1 and 3 attenuates KLF4 protein levels."
32685020
reach
"As anticipated, co-immunoprecipitation experiments revealed that OTUD7B interacted with and deubiquitylated KLF4."
32685020
OTUD7B ubiquitinates KLF4.
| 1
Modified OTUD7B leads to the ubiquitination of KLF4. 1 / 1
| 1
reach
"Reversely, OTUD7B overexpression in 293A cells markedly reduced the accumulation of ubiquitylated KLF4, whereas its knockdown had an opposite effect."
32685020
OTUD7B inhibits KLF4.
| 1
OTUD7B inhibits KLF4. 1 / 1
| 1
reach
"3) Third, we show for the first time that KLF4 downregulation elicited by Sal-miR-1 and 3 reduced expression of OTUD7B relieves KLF4 repression of the expression of VSMC differentiation genes (e.g. SM alpha-actin, SM22alpha, calponin and SMMHC) and thus increases their expression levels."
32685020
OTUD7B increases the amount of KLF4.
| 1
OTUD7B increases the amount of KLF4. 1 / 1
| 1
reach
"Further, using loss- and gain-of-function experiments, we confirmed that knockdown of OTUD7B attenuated KLF4 protein levels, whereas the overexpression of OTUD7B had the opposite effect."
32685020
OTUD7B affects HIF1A
1 | 1 5 1
OTUD7B activates HIF1A.
| 4
OTUD7B activates HIF1A. 4 / 9
| 4
reach
"Our data suggest that Cezanne is essential for HIF-1alpha protein stability and that loss of Cezanne stimulates HIF-1alpha degradation via proteasome independent routes, possibly through chaperone mediated autophagy."
25355043
reach
"Overall, these results imply that loss of Cezanne promotes degradation of HIF-1alpha in a proteasome independent manner."
25355043
reach
"Together, these data suggest that Cezanne does not impact solely on proteasomal degradation of HIF-1alpha, and raise the general question whether the canonical HIF-1alpha degradation machinery is required for Cezanne mediated HIF-1alpha downregulation."
25355043
reach
"OTUD7B, also known as Cezanne, deubiquitinates Lys11 linked Ub chains and rescues HIF-1alpha from lysosomal degradation."
33466790
OTUD7B inhibits HIF1A.
| 1
OTUD7B inhibits HIF1A. 1 / 2
| 1
eidos
"Under low LSS , the activation of NF-kappaB induces elevated HIF-1alpha mRNA and increased the expression of cezanne , a ubiquitin-editing enzyme preventing the HIF-1alpha protein degradation , thus stabilizing HIF-1alpha ."
33681205
OTUD7B binds HIF1A.
1 | 1
OTUD7B binds EPAS1 and HIF1A. 1 / 1
| 1
sparser
"Finally, despite being inconsistent to its role in the regulation of HIF-1α and HIF-2α, decreased Cezanne expression is associated with the progression and poor prognosis in hepatocellular carcinoma ( xref )."
27014628
OTUD7B binds HIF1A. 1 / 1
1 |
biogrid
No evidence text available
25355043
OTUD7B deubiquitinates HIF1A.
| 1
OTUD7B deubiquitinates HIF1A. 1 / 1
| 1
reach
"For example, OTU deubiquitinase 7B (OTUD7B) can deubiquitinate HIF-1alpha and inhibit its degradation by the lysosome."
32140262
KDM1A affects OTUD7B
| 5 9
OTUD7B binds KDM1A. 10 / 14
| 5 9
reach
"Taken all together, these results suggest that OTUD7B binds and stabilizes LSD1 via abrogating its ubiquitination‐dependent proteasomal degradation.2.2 OTUD7B Is a Bona Fide LSD1 Deubiquitinase."
34050636
reach
"In addition to USP22 and USP28, ectopic OTUD7B also bound robustly to endogenous LSD1 (Figure  1A )."
34050636
sparser
"Using OLco‐regulated gene sets revealed that loss of OTUD7B or LSD1 resulted in a significantly reduced expression of metastatic genes (Figure xref , Supporting Information), providing potential mechanistic clues explaining suppressed metastatic ability due to impaired OTUD7B–LSD1 signaling."
34050636
reach
"Of note, both wild type (WT) and the catalytically inactive form (CI, C194A/H358R) of OTUD7B bound ectopic LSD1 (Figure S1C,D, Supporting Information)."
34050636
sparser
"Taken all together, these results suggest that OTUD7B binds and stabilizes LSD1 via abrogating its ubiquitination‐dependent proteasomal degradation."
34050636
reach
"2.1 OTUD7B Binds LSD1 and Regulates Its Stability."
34050636
reach
"Interestingly, when compared to LSD1–CoREST complex, endogenous OTUD7B–LSD1 complex is readily detectable but with much less abundance, indicating OTUD7B may interact with LSD1 in a transient manner (Figure 1B)."
34050636
sparser
"Therefore, perturbation of OTUD7B–LSD1 axis results in changes in both activating and repressive chromatin modification marks, providing a plausible mechanism for altered gene transcription due to OTUD7B loss."
34050636
sparser
"In addition to USP22 and USP28, ectopic OTUD7B also bound robustly to endogenous LSD1 ( Figure   xref )."
34050636
sparser
"OTUD7B Binds LSD1 and Regulates Its Stability."
34050636
ZAP70 affects OTUD7B
| 4 9
ZAP70 binds OTUD7B. 10 / 11
| 4 7
sparser
"Domain mapping analyses revealed the requirement of the N-terminal UBA domain of Otud7b for its physical interaction with Zap70 ( xref ), indicating the facilitation of Otud7b–Zap70 interaction by ubiquitination."
26903241
reach
"Otud7b binds to and deubiquitinates Zap70."
26903241
sparser
"In response to TCR signaling, Otud7b was rapidly recruited to Zap70 via a mechanism that required the UBA domain of Otud7b, suggesting the possibility that Otud7b interacted with ubiquitinated Zap70."
26903241
sparser
"Interestingly, although Otud7b did not bind Zap70 in resting T cells, these two proteins formed a complex upon TCR–CD28 stimulation ( xref )."
26903241
sparser
"Upon TCR stimulation, OTUD7B binds to and deubiquitinates Zap70, thereby preventing the binding of Sts1 and 2 [ xref ]."
32248814
reach
"Otud7b binds to and deubiquitinates Zap70, thereby preventing the interaction of Zap70 with the negative-regulatory phosphatases, Sts1 and Sts2 199 (XREF_FIG)."
27012466
sparser
"In response to TCR–CD28 ligation, Otud7b rapidly bound to Zap70 and inhibited Zap70 ubiquitination."
26903241
reach
"In response to TCR-CD28 ligation, Otud7b rapidly bound to Zap70 and inhibited Zap70 ubiquitination."
26903241
sparser
"This ubiquitination-defective Zap70 mutant was also attenuated in association with Otud7b, consistent with the idea that the Zap70–Otud7b interaction might be facilitated by Zap70 ubiquitination ( xref )."
26903241
sparser
"The Otud7b–Zap70 interaction was further confirmed using a transient transfection experiment in which the overexpressed Otud7b strongly associated with Zap70 ( xref )."
26903241
USP9X binds ZAP70 and OTUD7B. 1 / 1
| 1
sparser
"Unlike Otud7b, USP9X does not directly interact with Zap70 but rather comes into the proximity of Zap70 via interaction with a LAT signaling complex [ xref ]."
30054854
ZAP70 binds OTUD7B and Sts1/2. 1 / 1
| 1
sparser
"Collectively, these data suggest that the enhanced interaction between Zap70 and Sts1/2 in Otud7b-deficient T cells contributes to attenuated Zap70 activation and TCR signaling."
26903241
OTUD7B affects MAP3K14
| 3 2 8
OTUD7B inhibits MAP3K14.
| 3 6
OTUD7B inhibits MAP3K14. 9 / 9
| 3 6
eidos
"In brief , OTUD7B deubiquitinates TRAF3 and inhibits NIK to suppress LCL161-induced lung cancer cell invasion and migration ."
33198776
sparser
"OTUD7B inhibits NIK to suppress LCL161-induced NF-κB pathway activation and cell elongation, invasion and migration."
33198776
eidos
"OTUD7B inhibits NIK to suppress LCL161-induced NF-kappaB pathway activation and cell elongation , invasion and migration ."
33198776
eidos
"Interestingly , we discovered that OTUD7B increases TRAF3 and decreases NIK to inhibit the non-canonical NF-kappaB pathway and that overexpression of OTUD7B suppresses LCL161-induced cell invasion and migration ."
33198776
sparser
"In our study, we found that overexpressed OTUD7B inhibits NIK and the non-canonical NF-κB pathway in lung cancer cells by binding to and deubiquitinating TRAF3."
33198776
sparser
"In our study, we found that overexpressed OTUD7B inhibits NIK and the non-canonical NF-κB pathway in lung cancer cells by binding to and deubiquitinating TRAF3."
33198776
sparser
"In brief, OTUD7B deubiquitinates TRAF3 and inhibits NIK to suppress LCL161-induced lung cancer cell invasion and migration."
33198776
sparser
"OTUD7B inhibits NIK to suppress LCL161-induced NF-κB pathway activation and cell elongation, invasion and migration."
33198776
sparser
"In brief, OTUD7B deubiquitinates TRAF3 and inhibits NIK to suppress LCL161-induced lung cancer cell invasion and migration."
33198776
OTUD7B binds MAP3K14.
| 2
TRAF3 binds OTUD7B and MAP3K14. 1 / 1
| 1
sparser
"Reciprocal co-immunoprecipitation was performed using anti-Flag anti-Myc and anti-HA antibodies to confirm whether OTUD7B directly binds to NIK or TRAF3."
33198776
OTUD7B binds MAP3K14. 1 / 1
| 1
sparser
"OTUD7B did not bind to NIK directly, but it did bind to TRAF3 (Fig.  xref a, b)."
33198776
OTUD7B deubiquitinates MAP3K14.
| 1
OTUD7B deubiquitinates MAP3K14. 1 / 1
| 1
reach
"Given that OTUD7B specifically regulates the NF-kappaB2 pathway and TRAF3 degradation, it would be of interest to determine if OTUD7B also deubiquitinates NIK."
26085206
OTUD7B activates MAP3K14.
| 1
OTUD7B activates MAP3K14. 1 / 1
| 1
reach
"TRAF3 and TRAF2 could recruit cIAP1/2 to catalyze K48‐linked ubiquitination and subsequent degradation of NIK.11, 12 NLRP12 or OTUD7B stabilizes TRAF3 and subsequently accelerates NIK degradation.13, 14 Lastly, IKKα and TBK1 may induce NIK phosphorylation‐dependent degradation.15, 16 In contrast to NIK, little is known about how the downstream subunit p100/p52 is regulated."
31921549
OTUD7B affects EGFR
1 1 | 7 2
OTUD7B deubiquitinates EGFR.
1 | 4
OTUD7B deubiquitinates EGFR. 5 / 5
1 | 4
reach
"OTUD7B deubiquitinated EGFR and facilitates downstream pathway MAPK."
31747939
reach
"Therefore, we hypothesized that OTUD7B may deubiquitinate EGFR and activate downstream pathway MAPK."
31747939
ubibrowser
"USP21 and Cezanne or OTUD7B negatively regulate NFκB signaling by deubiquitinating and inactivating RIP1 upon TNF-α?stimulation, providing a feedback loop in the proinflammatory signaling"
25121098
reach
"Ultimately, OTUD7B mediates EGFR deubiquitination and stability and MAPK signaling pathway activation, suggesting that linc00976/miR-137/OTUD7B/EGFR axis may act as a feasible therapeutic target for PC."
31747939
reach
"Therefore, we found that Linc00976 promoted proliferation and invasion via MAPK pathway, which is activated by OTUD7B mediated EGFR deubiquitination and stability.However, the mechanism of linc00976 regulating OTUD7B expression was still not clear."
31747939
OTUD7B binds EGFR.
1 | 1 2
OTUD7B binds EGFR. 4 / 4
1 | 1 2
reach
"Subsequently, the interaction between OTUD7B and EGFR was confirmed by co-immunoprecipitation and immunofluorescent staining (Fig. 6b, c)."
31747939
sparser
"Subsequently, the interaction between OTUD7B and EGFR was confirmed by co-immunoprecipitation and immunofluorescent staining (Fig. xref b, c)."
31747939
biogrid
No evidence text available
22179831
sparser
"The results presented in xref confirmed that Cezanne-1 overexpression associates with remarkably reduced ubiquitination of EGFR, as well as with stabilization the receptor and an increase in auto-phosphorylation."
22179831
OTUD7B activates EGFR.
| 1
OTUD7B activates EGFR. 1 / 2
| 1
reach
"Ultimately, OTUD7B mediates EGFR and MAPK signaling pathway, suggesting that linc00976/miR-137/OTUD7B/EGFR axis may act as a potential biomarker and therapeutic target for PC."
31747939
OTUD7B increases the amount of EGFR.
| 1
OTUD7B increases the amount of ubiquitinated EGFR. 1 / 1
| 1
reach
"The ubiquitination assay showed that ectopic expression of OTUD7B could increase the amount of poly-ubiquitinated EGFR, and the EGFR ubiquitination level was partly restrained in OTUD7B downregulated PC cells (Fig. 6e)."
31747939
PARK7 affects OTUD7B
3 | 1 5
PARK7 binds OTUD7B. 8 / 10
3 | 1 4
biogrid
No evidence text available
21097510
sparser
"The interaction of DJ-1 with Cezanne was shown by mass spectrometry and co-immunoprecipitation."
25593990
sparser
"Co-immunoprecipitation experiment was utilized to assess the DJ-1-Cezanne interaction."
34374892
biogrid
No evidence text available
21097510
trips
"DJ-1 activates the noncanonical NF-kappaB pathway via interaction with Cezanne to inhibit the apoptosis and promote the proliferation of Ishikawa cells."
34374892
biogrid
No evidence text available
21097510
sparser
"DJ-1 also directly interacts with Cezanne, which networks with NF-κβ reducing its nuclear translocation working as a physiological inhibitor of its transcriptional activity [ xref ]."
30274236
sparser
"DJ-1 directly interacts with one of its binding partners, Cezanne, which is a physiological inhibitor of the transcription activity of NF-κβ [ xref ]."
25593990
RIPK1 binds PARK7 and OTUD7B. 1 / 1
| 1
sparser
"Cezanne interacts with DJ-1 and targets RIPK1 signaling intermediates, thereby suppressing NF-κB nuclear translocation and its activity [ xref , xref ]."
32549302
OTUD7B affects TRAF6
1 2 1 | 3 2
OTUD7B binds TRAF6.
1 2 | 1 1
TRAF6 binds OTUD7B. 4 / 5
1 2 | 1
reach
"ZA20D1 can associate with Traf6 and is possibly an antagonist to Traf6."
22450746
hprd
No evidence text available
9928991
hprd
No evidence text available
11463333
biogrid
No evidence text available
11463333
TRAF6 binds OTUD7B and ZRANB1. 1 / 1
| 1
sparser
"Co-immunoprecipitation studies indicated that TRAF6 was able to interact with both Cezanne and TRABID."
11463333
OTUD7B ubiquitinates TRAF6.
| 1 1
OTUD7B leads to the ubiquitination of TRAF6. 2 / 2
| 1 1
sparser
"The modulation of TRAF6 and RIP1 ubiquitination by Cezanne was playing a pivotal role in relation to the mechanism of SFN inhibiting NF-κB pathway."
33010279
reach
"Similar to A20, Cezanne also was shown to suppress NF-κB signaling by deubiquitinating K63-polyUb from RIPK1 [68,69] and TRAF6 [70]."
31208841
OTUD7B deubiquitinates TRAF6.
1 | 1
OTUD7B leads to the deubiquitination of TRAF6. 2 / 2
1 | 1
reach
"These data indicate that endogenous Cezanne suppresses TRAF6 polyubiquitination in response to hypoxia-reoxygenation."
23564640
ubibrowser
"Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination"
23564640
OTUD7B affects ESR1
| 3 7
OTUD7B binds ESR1.
| 2 7
OTUD7B binds ESR1. 8 / 8
| 2 6
sparser
"GST pull-down assay showed that OTUD7B directly interacted with ERα in vitro (Fig. xref )."
34035221
reach
"OTUD7B could interact with, deubiquitylate, and stabilize ERalpha in a deubiquitylation activity dependent manner."
34035221
sparser
"GST pull-down assay showed that OTUD7B interacted with ERα in vitro in a DUB-activity-dependent manner."
34035221
reach
"Targeting the OTUD7B and ERalpha complex may prove to be a potential approach to treat patients with ERalpha positive breast cancer."
34035221
sparser
"The interaction between OTUD7B and ERα suggested that ERα might be a substrate of OTUD7B, and therefore we evaluated the possibility of ERα deubiquitylation by OTUD7B. It was found that OTUD7B deletion dramatically decreased ERα protein level, and this effect could be reversed by addition of the proteasome inhibitor MG132 or overexpression of OTUD7B-WT, but not its catalytically inactive mutant OTUD7B C194S (Fig. xref )."
34035221
sparser
"Targeting the OTUD7B–ERα complex may prove to be a potential approach to treat patients with ERα-positive breast cancer."
34035221
sparser
"OTUD7B interacts with ERα."
34035221
sparser
"OTUD7B was associated with ERα and inhibits ERα polyubiquitination and degradation."
34035221
OTUD7B binds ESR1 and IFNGR2. 1 / 1
| 1
sparser
"Additionally, deletion analysis demonstrated that OTUD7B physically interacted with the AF1 domain of ERα (Fig. xref )."
34035221
OTUD7B decreases the amount of ESR1.
| 1
OTUD7B decreases the amount of ESR1. 1 / 1
| 1
reach
"Depletion of OTUD7B decreased ERalpha protein level, the expression of ERalpha target genes, and the activity of estrogen response element in breast cancer cells."
34035221
OTUD7B is modified
9 | 1
OTUD7B is phosphorylated.
9 |
OTUD7B is phosphorylated on S100. 3 / 3
3 |
hprd
No evidence text available
18212344
hprd
No evidence text available
18669648
hprd
No evidence text available
20068231
OTUD7B is phosphorylated on S464. 3 / 3
3 |
hprd
No evidence text available
18669648
hprd
No evidence text available
16964243
hprd
No evidence text available
19413330
OTUD7B is phosphorylated on S467. 2 / 2
2 |
hprd
No evidence text available
18669648
hprd
No evidence text available
19413330
OTUD7B is phosphorylated on S449. 1 / 1
1 |
hprd
No evidence text available
20068231
OTUD7B is hydroxylated.
| 1
OTUD7B is hydroxylated. 1 / 1
| 1
sparser
"Cezanne is hydroxylated at Asn35 of the UBA domain in an oxygen- or FIH1-dependent manner, which inhibits the binding of Ub to Cezanne ( xref )."
34177595
ESR1 affects OTUD7B
1 | 2 7
ESR1 binds OTUD7B.
| 2 7
OTUD7B binds ESR1. 8 / 8
| 2 6
sparser
"GST pull-down assay showed that OTUD7B directly interacted with ERα in vitro (Fig. xref )."
34035221
reach
"OTUD7B could interact with, deubiquitylate, and stabilize ERalpha in a deubiquitylation activity dependent manner."
34035221
sparser
"GST pull-down assay showed that OTUD7B interacted with ERα in vitro in a DUB-activity-dependent manner."
34035221
reach
"Targeting the OTUD7B and ERalpha complex may prove to be a potential approach to treat patients with ERalpha positive breast cancer."
34035221
sparser
"The interaction between OTUD7B and ERα suggested that ERα might be a substrate of OTUD7B, and therefore we evaluated the possibility of ERα deubiquitylation by OTUD7B. It was found that OTUD7B deletion dramatically decreased ERα protein level, and this effect could be reversed by addition of the proteasome inhibitor MG132 or overexpression of OTUD7B-WT, but not its catalytically inactive mutant OTUD7B C194S (Fig. xref )."
34035221
sparser
"Targeting the OTUD7B–ERα complex may prove to be a potential approach to treat patients with ERα-positive breast cancer."
34035221
sparser
"OTUD7B interacts with ERα."
34035221
sparser
"OTUD7B was associated with ERα and inhibits ERα polyubiquitination and degradation."
34035221
OTUD7B binds ESR1 and IFNGR2. 1 / 1
| 1
sparser
"Additionally, deletion analysis demonstrated that OTUD7B physically interacted with the AF1 domain of ERα (Fig. xref )."
34035221
ESR1 decreases the amount of OTUD7B.
1 |
ESR1 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:msigdb
No evidence text available
UBC affects OTUD7B
8 1 |
UBC binds OTUD7B. 9 / 9
8 1 |
hprd
No evidence text available
12682062
biogrid
No evidence text available
25752577
biogrid
No evidence text available
22179831
biogrid
No evidence text available
25723849
biogrid
No evidence text available
27732584
biogrid
No evidence text available
23827681
biogrid
No evidence text available
20622874
biogrid
No evidence text available
26876099
biogrid
No evidence text available
27732584
TRAF3 affects OTUD7B
| 5 4
TRAF3 binds OTUD7B. 8 / 8
| 5 3
reach
"In response to noncanonical NF-kappaB stimuli, Otud7b binds and deubiquitinates TRAF3, thereby inhibiting TRAF3 proteolysis and preventing aberrant noncanonical NF-kappaB activation."
23334419
reach
"Non-canonical NF-κB activators induce the interaction of OTUD7B and TRAF3, thereby down-regulating TRAF3 ubiquitination and degradation and preventing aberrant non-canonical NF-κB activation."
32958760
sparser
"Notably, OTUD7B directly binds to TRAF3 rather than to NIK and deubiquitinates TRAF3, thereby inhibiting TRAF3 proteolysis and preventing NIK accumulation and NF-κB pathway activation."
33198776
reach
"We found that Traf3 physically interacted with Otud7b in T cells (unpublished data), although we could not detect appreciable degradation of Traf3 along with TCR-CD28 ligation in either WT or Otud7b deficient T cells."
26903241
sparser
"Non-canonical NF-κB activators induce the interaction of OTUD7B and TRAF3, thereby down-regulating TRAF3 ubiquitination and degradation and preventing aberrant non-canonical NF-κB activation."
32958760
sparser
"We found that Traf3 physically interacted with Otud7b in T cells (unpublished data), although we could not detect appreciable degradation of Traf3 along with TCR–CD28 ligation in either WT or Otud7b-deficient T cells."
26903241
reach
"Upon ligation of these receptors, Otud7b binds to TRAF3, and this inducible interaction requires a ubiquitin association (UBA) domain present in the N-terminus of Otud7b, suggesting the possibility that ubiquitination of TRAF3 may facilitate its binding by Otud7b."
26085207
reach
"Activation of BAFFR increases OTUD7B expression and the newly synthesized deubiquitinase then binds to TRAF3 resulting in the formation of a high molecular weight complex including OTUDB7, TRAF3, TRAF2, and cIAP1/2."
30349534
TRAF3 binds OTUD7B and MAP3K14. 1 / 1
| 1
sparser
"Reciprocal co-immunoprecipitation was performed using anti-Flag anti-Myc and anti-HA antibodies to confirm whether OTUD7B directly binds to NIK or TRAF3."
33198776
OTUD7B affects migration
| 9
OTUD7B inhibits migration.
| 7
OTUD7B inhibits migration. 7 / 7
| 7
eidos
"OTUD7B suppresses Smac mimetic-induced lung cancer cell invasion and migration via deubiquitinating TRAF3 ."
33198776
eidos
"However , whether OTUD7B can inhibit LCL161-induced invasion and migration and be used to select a target population in LCL161 treatment for lung cancer is unclear ."
33198776
eidos
"OTUD7B inhibits NIK to suppress LCL161-induced NF-kappaB pathway activation and cell elongation , invasion and migration ."
33198776
eidos
"Furthermore , OTUD7B can inhibit LCL161-induced lung cancer cell invasion and migration by deubiquitinating TRAF3 , inhibiting NIK and preventing non-canonical NF-kappaB activation ."
33198776
eidos
"* P < 0.05 OTUD7B inhibits NIK to suppress LCL161-induced NF-kappaB pathway activation and cell elongation , invasion and migration To investigate how OTUD7B inhibits LCL161-induced cell elongation , invasion and migration , we established H1299 cells that overexpressed OTUD7B ."
33198776
eidos
"Moreover , OTUD7B inhibits LCL161-induced invasion and migration by binding to and deubiquitinating TRAF3 , thereby inhibiting NIK and preventing non-canonical NF-kappaB activation ."
33198776
eidos
"OTUD7B suppresses Smac mimetic-induced lung cancer cell invasion and migration via deubiquitinating TRAF3 Background Smac mimetics are a type of drug that can induce apoptosis by antagonizing IAP family members in cancer treatment ."
33198776
OTUD7B activates migration.
| 2
OTUD7B activates migration. 2 / 2
| 2
eidos
"Its increased expression has been reported in lung squamous carcinoma and adenocarcinoma compared to normal tissue ; in the same cancer model , OTUD7B promoted cell proliferation , migration and metastasization [ 45 ] ."
33371395
eidos
"In addition , OTUD7B depletion significantly decreased ERalpha-positive breast cancer cell proliferation and migration ."
34035221
OTUD7B affects UBC
8 1 |
UBC binds OTUD7B. 9 / 9
8 1 |
hprd
No evidence text available
12682062
biogrid
No evidence text available
25752577
biogrid
No evidence text available
22179831
biogrid
No evidence text available
25723849
biogrid
No evidence text available
27732584
biogrid
No evidence text available
23827681
biogrid
No evidence text available
20622874
biogrid
No evidence text available
26876099
biogrid
No evidence text available
27732584
Hypoxia affects OTUD7B
| 3 6
Hypoxia activates OTUD7B.
| 2 5
Hypoxia activates OTUD7B. 7 / 7
| 2 5
eidos
"There is also evidence showing that hypoxia can induce OTUD7B via a p38 MAPK pathway [ 126 ] and UCHL1 expression involving a HIF-alpha-mediated mechanism [ 144 ] ."
31208103
reach
"Studies of cultured endothelial cells (EC) demonstrated that hypoxia (1% oxygen) induced Cezanne via p38 MAP kinase-dependent transcriptional and post- transcriptional mechanisms."
23564640
reach
"Our finding that Cezanne can be induced by hypoxia in vitro led us to examine the expression of Cezanne in tissues exposed to ischemia in vivo."
23564640
reach
"Activation of HIF1α in response to dimethyloxallyl glycine, desferrioxamine or CoCl did not influence Cezanne expression (Online Fig. III) and silencing of HIF1α or HIF2α did not suppress Cezanne expression in hypoxic EC (Online Fig. IV), indicating that induction of Cezanne by hypoxia is HIF-independent."
23564640
reach
"Hypoxia induces Cezanne via transcriptional and post-transcriptional mechanisms."
23564640
reach
"This level of hypoxia (1% O2) also induced Cezanne in cultured microvascular EC at both the mRNA (Fig. 1C) and protein levels (Online Fig. II)."
23564640
eidos
"Methods and Results Studies of cultured endothelial cells ( EC ) demonstrated that hypoxia ( 1 % oxygen ) induced Cezanne via p38 MAP kinase-dependent transcriptional and post - transcriptional mechanisms ."
23564640
Hypoxia inhibits OTUD7B.
| 1 1
Hypoxia inhibits OTUD7B. 2 / 2
| 1 1
reach
"We observed that silencing of ATF2 using two different siRNA sequences suppressed the induction of Cezanne by hypoxia (Fig. 2B)."
23564640
eidos
"We observed that silencing of ATF2 using two different siRNA sequences suppressed the induction of Cezanne by hypoxia ( Fig. 2B ) ."
23564640
OTUD7B affects RIPK1
1 1 | 4 2
OTUD7B deubiquitinates RIPK1.
1 1 | 1
OTUD7B leads to the deubiquitination of RIPK1. 2 / 2
1 | 1
reach
"OTUD7B, a newly identified member of the A20 family of DUBs, inhibits RIP1 ubiquitination and downstream IKK activity and NF-kappaB signalling [XREF_BIBR]."
25595906
ubibrowser
"USP21 and Cezanne or OTUD7B negatively regulate NFκB signaling by deubiquitinating and inactivating RIP1 upon TNF-α?stimulation, providing a feedback loop in the proinflammatory signaling"
25121098
OTUD7B deubiquitinates RIPK1 on K377. 1 / 1
1 |
biopax:reactome
No evidence text available
OTUD7B ubiquitinates RIPK1.
| 1 1
OTUD7B leads to the ubiquitination of RIPK1. 2 / 2
| 1 1
reach
"Similar to A20, Cezanne also was shown to suppress NF-κB signaling by deubiquitinating K63-polyUb from RIPK1 [68,69] and TRAF6 [70]."
31208841
sparser
"The modulation of TRAF6 and RIP1 ubiquitination by Cezanne was playing a pivotal role in relation to the mechanism of SFN inhibiting NF-κB pathway."
33010279
OTUD7B decreases the amount of RIPK1.
| 2
OTUD7B decreases the amount of RIPK1. 2 / 2
| 2
reach
"USP21 and Cezanne inhibit TNF-κB activation by regulating ubiquitin level of RIPK1 (D'Arcy et al., 2015)."
27211605
reach
"USP21 and Cezanne inhibit TNF-B activation by regulating ubiquitin level of RIPK1 (D'Arcy et al., 2015) ."
27211605
OTUD7B binds RIPK1.
| 1
RIPK1 binds PARK7 and OTUD7B. 1 / 1
| 1
sparser
"Cezanne interacts with DJ-1 and targets RIPK1 signaling intermediates, thereby suppressing NF-κB nuclear translocation and its activity [ xref , xref ]."
32549302
reach
"OTUD7B stabilizes estrogen receptor alpha and promotes breast cancer cell proliferation."
34035221
reach
"The present study demonstrates that linc00976 enhances the proliferation and invasion ability of PC cells by upregulating OTUD7B expression, which was a target of miR-137."
31747939
eidos
"Its increased expression has been reported in lung squamous carcinoma and adenocarcinoma compared to normal tissue ; in the same cancer model , OTUD7B promoted cell proliferation , migration and metastasization [ 45 ] ."
33371395
reach
"Recently, OTUD7B and Cezannehas been reported to deubiquitinate and stabilize the APC/C substrates, as well as promote mitotic progression and cell proliferation."
33643919
reach
"These findings collectively identified OTUD7B as an independent predictive factor for the prognosis of non small cell lung cancer and revealed OTUD7B promotes lung cancer cell proliferation and metastasis via Akt and VEGF signal pathway."
31572671
reach
"Its increased expression has been reported in lung squamous carcinoma and adenocarcinoma compared to normal tissue; in the same cancer model, OTUD7B promoted cell proliferation, migration and metastasization [XREF_BIBR]."
33371395
OTUD7B inhibits cell population proliferation. 1 / 1
| 1
reach
"In addition, OTUD7B depletion significantly decreased ERalpha positive breast cancer cell proliferation and migration."
34035221
E2F1 affects OTUD7B
7 |
E2F1 decreases the amount of OTUD7B. 7 / 7
7 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
P38 affects OTUD7B
| 1 5
P38 activates OTUD7B.
| 1 3
P38 activates OTUD7B. 4 / 4
| 1 3
reach
"Here we describe a novel form of cross-talk between the NF-κB and MAP kinase pathways where p38-dependent induction of Cezanne during hypoxia suppresses NF-κB activity."
23564640
eidos
"We examined the mechanism of Cezanne induction by p38 , which is known to influence gene expression via members of the activating transcription factor ( ATF ) family and also by enhancing mRNA stability25 ."
23564640
reach
"P38 also enhanced the stability of Cezanne transcripts in hypoxic EC as pharmacological inhibition of p38 using SB202190 destabilized Cezanne mRNA in actinomycin D chase experiments (Online Fig. V)."
23564640
reach
"Thus we conclude that p38 induces Cezanne through both transcriptional and post-transcriptional mechanisms."
23564640
P38 increases the amount of OTUD7B.
| 1
P38 increases the amount of OTUD7B. 1 / 1
| 1
reach
"By contrast, pharmacological inhibition of p38 using either CT8730 or SB202190 (Fig. 1E,F) or gene silencing of p38α (Fig. 1G) suppressed the induction of Cezanne by hypoxia, indicating that p38 positively regulates Cezanne expression."
23564640
P38 decreases the amount of OTUD7B.
| 1
P38 decreases the amount of OTUD7B. 1 / 1
| 1
reach
"By contrast, pharmacological inhibition of p38 using either CT8730 or SB202190 (Fig. 1E,F) or gene silencing of p38α (Fig. 1G) suppressed the induction of Cezanne by hypoxia, indicating that p38 positively regulates Cezanne expression."
23564640
TRAF6 affects OTUD7B
1 2 | 1 1
TRAF6 binds OTUD7B. 4 / 5
1 2 | 1
reach
"ZA20D1 can associate with Traf6 and is possibly an antagonist to Traf6."
22450746
hprd
No evidence text available
9928991
hprd
No evidence text available
11463333
biogrid
No evidence text available
11463333
TRAF6 binds OTUD7B and ZRANB1. 1 / 1
| 1
sparser
"Co-immunoprecipitation studies indicated that TRAF6 was able to interact with both Cezanne and TRABID."
11463333
reach
"In vascular endothelial cells, OTUD7B could reduce inflammation and injury in response to ischemia-reperfusion XREF_BIBR."
32685020
reach
"We translated our in vitro findings to a murine model by demonstrating that renal inflammation and injury in response to ischemia/reperfusion is enhanced by genetic deletion of Cezanne."
23564640
eidos
"In vascular endothelial cells , OTUD7B could reduce inflammation and injury in response to ischemia-reperfusion 45 ."
32685020
reach
"Cezanne reduces inflammation and injury in response to ischemia-reperfusion."
23564640
eidos
"OTUD7B reduces inflammation and injury in response to ischemia-reperfusion by suppressing tumor necrosis factor receptor-associated factor 6 ( TRAF6 ) polyubiquitination 48 ."
32685020
reach
"Our observation that endogenous Cezanne can reduce inflammation and injury in response to ischemia-reperfusion has important implications for therapeutic targeting of inflammation during transplantation of vascularised organs, bypass grafting, percutaneous coronary intervention of arteries and other procedures that involve reperfusion."
23564640
OTUD7B affects Ubiquitin
| 4 2
OTUD7B decreases the amount of Ubiquitin.
| 4
Modified OTUD7B decreases the amount of Ubiquitin. 2 / 2
| 2
reach
"In contrast, only overexpression of Otubain 1 and Cezanne moderately decreased cellular global Ub conjugate levels, while expression of A20 or Otubain 2 had no effect on total levels of ubiquitinated proteins (Balakirev et al., 2003, Evans et al., 2003, Evans et al., 2004)."
18078692
reach
"In contrast, only overexpression of mammalian Otubain 1 and Cezanne moderately decreased cellular global Ub conjugate levels, while expression of A20 or Otubain 2 had no effect on total levels of ubiquitinated proteins (Balakirev et al., 2003; Evans et al., 2004; Evans et al., 2003) ."
18078692
OTUD7B decreases the amount of Ubiquitin. 2 / 2
| 2
reach
"USP21 and Cezanne inhibit TNF-B activation by regulating ubiquitin level of RIPK1 (D'Arcy et al., 2015) ."
27211605
reach
"USP21 and Cezanne inhibit TNF-κB activation by regulating ubiquitin level of RIPK1 (D'Arcy et al., 2015)."
27211605
OTUD7B binds Ubiquitin.
| 2
sparser
"DUB linkage specificity relies on careful positioning of the proximal Ub, which interacts with Cezanne via an unusual surface, involving Thr12, Glu16 and its α-helix (Asp32, Lys33, Glu34, Gly35) ( xref , xref )."
27732584
sparser
"Cezanne is hydroxylated at Asn35 of the UBA domain in an oxygen- or FIH1-dependent manner, which inhibits the binding of Ub to Cezanne ( xref )."
34177595
NS5A affects OTUD7B
| 3 3
NS5A binds OTUD7B.
| 2 3
OTUD7B binds NS5A. 5 / 5
| 2 3
sparser
"Taken together, these results suggest that HCV NS5A protein interacts with OTUD7B, thereby modulating its DUB activity."
26112491
reach
"Co-immunoprecipitation analyses showed that NS5A interacts with OTUD7B in both Huh-7 and HCV RNA replicon cells."
26112491
sparser
"Either V121A or V124A mutation in NS5A disrupts the NS5A-OTUD7B interaction."
26112491
sparser
"Co-immunoprecipitation analyses showed that NS5A interacts with OTUD7B in both Huh-7 and HCV RNA replicon cells."
26112491
reach
"Taken together, these results suggest that HCV NS5A protein interacts with OTUD7B, thereby modulating its DUB activity."
26112491
NS5A activates OTUD7B.
| 1
NS5A activates OTUD7B. 1 / 1
| 1
reach
"The results of this in vivo ubiquitylation assay suggest that HCV NS5A enhances OTUD7B DUB activity."
26112491
TNF affects OTUD7B
| 4
TNF activates OTUD7B. 4 / 5
| 4
reach
"Cezanne is induced by TNF‐alpha in cultured cells leading to down‐regulation of NF‐κB signalling through the deubiquitination and inactivation of RIP1, thereby providing a negative feedback loop in pro‐inflammatory signalling (85)."
20073038
reach
"Our subsequent studies revealed that Cezanne can be induced by TNFα, IL-1 and functions as an inhibitor of NF-κB, thus forming a negative feedback loop in inflammatory cytokine signalling , and a recent report indicated that Cezanne can also influence non-canonical NF-κB activation ."
23564640
reach
"Given that Cezanne can be modulated by shear stress, TNFα, IL-1 and reactive oxygen species , future studies should address whether these factors influence inflammatory responses to hypoxia-reoxygenation by altering the expression and/or activity of Cezanne."
23564640
reach
"Cezanne is induced by TNF-alpha in cultured cells leading to down-regulation of NF-jB signalling through the deubiquitination and inactivation of RIP1, thereby providing a negative feedback loop in pro-inflammatory signalling (85) ."
20073038
TFDP1 affects OTUD7B
5 |
TFDP1 decreases the amount of OTUD7B. 5 / 5
5 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
SHBG affects OTUD7B
| 2 3
SHBG binds OTUD7B.
| 1 3
SHBG binds OTUD7B and DiUb. 2 / 2
| 2
sparser
"A detailed analysis of internal K11-linked diUb ABP binding to Cezanne revealed that recognition of S1′ site ubiquitin leads to a large dynamic conformational change and subsequent catalysis in Cezanne."
| PMC
sparser
"A detailed analysis of internal K11-linked diUb ABP binding to Cezanne revealed that recognition of S1 0 site ubiquitin leads to a large dynamic conformational change and subsequent catalysis in Cezanne."
| PMC
SHBG binds OTUD7B. 1 / 1
| 1
sparser
"A detailed analysis of internal K11-linked diUb ABP binding to Cezanne revealed that recognition of S1′ site ubiquitin leads to a large dynamic conformational change and subsequent catalysis in Cezanne."
| PMC
SHBG binds OTUD7B and S1. 1 / 1
| 1
reach
"Furthermore, mutations in the S2 site using K48-linked diUb-AMC substrates showed a drastic reduction in hydrolysis supporting the importance of S2 site binding of distal Ub.A detailed analysis of internal K11-linked diUb ABP binding to Cezanne revealed that recognition of S1 0 site ubiquitin leads to a large dynamic conformational change and subsequent catalysis in Cezanne."
| PMC
SHBG activates OTUD7B.
| 1
SHBG bound to S1 and OTUD7B activates OTUD7B. 1 / 1
| 1
reach
"Furthermore, mutations in the S2 site using K48-linked diUb-AMC substrates showed a drastic reduction in hydrolysis supporting the importance of S2 site binding of distal Ub.A detailed analysis of internal K11-linked diUb ABP binding to Cezanne revealed that recognition of S1 0 site ubiquitin leads to a large dynamic conformational change and subsequent catalysis in Cezanne."
| PMC
OTUD7B affects Neoplasm Invasiveness
| 2 2 1
OTUD7B inhibits Neoplasm Invasiveness.
| 2 1 1
OTUD7B inhibits Neoplasm Invasiveness. 4 / 4
| 2 1 1
sparser
"Further study indicated that Cezanne might inhibit invasion of HCC cells by inducing epithelial-mesenchymal transition (EMT)."
28880268
reach
"Depletion of ZA20D1 also reduced SCC invasion, which further suggests that it has additional functions besides antagonising Traf6 (XREF_SUPPLEMENTARY)."
22450746
eidos
"OTUD7B inhibits NIK to suppress LCL161-induced NF-kappaB pathway activation and cell elongation , invasion and migration ."
33198776
eidos
"* P < 0.05 OTUD7B inhibits NIK to suppress LCL161-induced NF-kappaB pathway activation and cell elongation , invasion and migration To investigate how OTUD7B inhibits LCL161-induced cell elongation , invasion and migration , we established H1299 cells that overexpressed OTUD7B ."
33198776
OTUD7B activates Neoplasm Invasiveness.
| 1
reach
"The present study demonstrates that linc00976 enhances the proliferation and invasion ability of PC cells by upregulating OTUD7B expression, which was a target of miR-137."
31747939
OTUD7B affects NS5A
| 2 3
OTUD7B binds NS5A. 5 / 5
| 2 3
sparser
"Taken together, these results suggest that HCV NS5A protein interacts with OTUD7B, thereby modulating its DUB activity."
26112491
reach
"Co-immunoprecipitation analyses showed that NS5A interacts with OTUD7B in both Huh-7 and HCV RNA replicon cells."
26112491
sparser
"Either V121A or V124A mutation in NS5A disrupts the NS5A-OTUD7B interaction."
26112491
sparser
"Co-immunoprecipitation analyses showed that NS5A interacts with OTUD7B in both Huh-7 and HCV RNA replicon cells."
26112491
reach
"Taken together, these results suggest that HCV NS5A protein interacts with OTUD7B, thereby modulating its DUB activity."
26112491
OTUD7B affects MAPK
| 4 1
OTUD7B activates MAPK.
| 3 1
OTUD7B activates MAPK. 4 / 4
| 3 1
reach
"As TRAF3 is dispensable for the activation of canonical NF-kappaB and MAPK signaling OTUD7B does not affect these pathways."
24391645
sparser
"Therefore, we hypothesized that OTUD7B may deubiquitinate EGFR and activate downstream pathway MAPK."
31747939
reach
"Ultimately, OTUD7B mediates EGFR and MAPK signaling pathway, suggesting that linc00976/miR-137/OTUD7B/EGFR axis may act as a potential biomarker and therapeutic target for PC."
31747939
reach
"This prevents miR-137 from binding and suppressing OTUD7B mRNA, resulting in OTUD7B dependent activation of the EFGR and MAPK pathway."
33414429
OTUD7B decreases the amount of MAPK.
| 1
OTUD7B decreases the amount of MAPK. 1 / 1
| 1
reach
"qRT-PCR illustrated that miR-137 downregulated promotes the mRNA express level of MAPK target genes (CyclinD1, CDK2, MMP2, MMP9), Linc00976 and OTUD7B downregulating could reverse the effect in Linc00976U PC cells (Fig. 7g)."
31747939
OTUD7B affects KLF4 protein
| 5
OTUD7B activates KLF4 protein. 5 / 5
| 5
eidos
"We show here that OTUB7B upregulates the level of KLF4 protein , a stem cell pluripotency protein 41 , through interacting with and deubiquitylating KLF4 , a repressor of VSMC differentiation , whereas OTUD7B downregulation by Sal-miR-1 and 3 attenuates KLF4 protein level ."
32685020
eidos
"Further , using loss - and gain-of-function experiments , we confirmed that knockdown of OTUD7B attenuated KLF4 protein levels , whereas the overexpression of OTUD7B had the opposite effect ."
32685020
eidos
"Most importantly , OTUD7B downregulation by Sal-miR-1 and 3 attenuates KLF4 protein levels via decreasing its deubiquitylation , whereas decreased KLF4 relieves its repression of transcription of NMHC IIA gene and thus increases NMHC IIA expression levels ."
32685020
eidos
"Our findings reveal , for the first time , that OTUD7B upregulates the level of KLF4 protein through interacting with and deubiquitylating KLF4 ."
32685020
eidos
"KLF4 negatively regulates NMHC IIA expression , and downregulation of KLF4 by Sal-miR-1 and 3 reduces KLF4 repression of the expression of NMHC IIA and thus increases NMHC IIA expression level Because Sal-miR-1 and 3 downregulated KLF4 protein levels by attenuating OTUD7B expression , we sought to determine KLF4 target genes associated with induction of VSMC migration ."
32685020
OTUD7B affects AKT
| 3 1
OTUD7B activates AKT.
| 2
OTUD7B activates AKT. 2 / 3
| 2
reach
"OTUD7B mediated cleavage of K63 linked polyubiquitin chains on GbetaL appears to be a common mechanism to promote mTORC2 and AKT signalling, as knockdown of OTUD7B downregulated AKT (pS473) and conferred chemosensitivity to cancer cells with elevated mTORC2 and AKT signalling due to oncogenic events such as PTEN deletion, PIK3CA, EGFR or KRAS mutations (XREF_FIG)."
28489822
reach
"In support of a physiologically pivotal role for OTUD7B in the activation of mTORC2 and AKT signalling, genetic deletion of Otud7b in mice suppresses Akt activation and Kras driven lung tumorigenesis in vivo."
28489822
OTUD7B phosphorylates AKT.
| 1
OTUD7B phosphorylates AKT on S473. 1 / 1
| 1
sparser
"As such it would be expected that both CUL4B-DDB1 and TRAF2 enhance mTORC1 dependent S6K and 4E-BP1 phosphorylation while UCH-L1 and OTUD7B enhance mTORC2 dependent AKT phosphorylation at S473."
28923280
OTUD7B dephosphorylates AKT.
| 1
OTUD7B leads to the dephosphorylation of AKT. 1 / 1
| 1
reach
"Otud7b deficiency inhibited TCR-CD28-stimulated phosphorylation of Zap70, Akt, and Erks in both naive CD4 + T cells (XREF_FIG) and naive CD8 + T cells (XREF_FIG)."
26903241
F2 affects OTUD7B
| 2 3
F2 activates OTUD7B.
| 2 2
F2 activates OTUD7B. 4 / 4
| 2 2
reach
"Importantly, when VSMCs were transfected with Sal-miR-1 and 3 and then treated with thrombin, the upregulation of OTUD7B by thrombin was greatly abolished."
32685020
eidos
"We first observed that thrombin significantly increased OTUD7B expression both at the protein and mRNA levels in a dose - and time-dependent manner ( Figure 3A-D ) ."
32685020
reach
"In this study, our results showed that Sal-miR-1 and 3 reduced the upregulation of the OTUD7B mRNA and protein induced by thrombin."
32685020
eidos
"Importantly , when VSMCs were transfected with Sal-miR-1 and 3 and then treated with thrombin , the upregulation of OTUD7B by thrombin was greatly abolished ( Figure 3E-F ) ."
32685020
F2 increases the amount of OTUD7B.
| 1
F2 increases the amount of OTUD7B. 1 / 1
| 1
reach
"We first observed that thrombin significantly increased OTUD7B expression both at the protein and mRNA levels in a dose- and time dependent manner."
32685020
OTUD7B affects pathway
| 4
OTUD7B inhibits pathway.
| 3
OTUD7B inhibits pathway. 3 / 3
| 3
sparser
"A previous study showed that OTUD7B can inhibit the NF-κB pathway in liver cancer [ xref ]."
33198776
sparser
"To examine the potential mechanism by which OTUD7B inhibits the LCL161-induced NF-κB pathway, we transfected Flag-TRAF3 and HA-OTUD7B, Myc-NIK and HA-OTUD7B into H1299 cells for 48 h."
33198776
sparser
"Previous studies have shown that OTUD7B inhibited NF-κB pathway by deconjugating K63-polyubiquitin chains from RIP-1 and TRAF6, suggesting that it may have roles in inhibition of cancer progression xref , xref ."
32685020
OTUD7B activates pathway.
| 1
OTUD7B activates pathway. 1 / 1
| 1
sparser
"This prevents miR-137 from binding and suppressing OTUD7B mRNA, resulting in OTUD7B-dependent activation of the EFGR/MAPK pathway."
33414429
OTUD7B affects miR-1180
| 4
OTUD7B inhibits miR-1180.
| 3
OTUD7B inhibits miR-1180. 3 / 3
| 3
reach
"We also indicate a mechanism for miR-1180 induced drug resistance by downregulation of OTUD7B, TNIP2 and BAD, the direct targets of miR-1180 in HCC cells."
26928365
reach
"As predicted, western blotting revealed that the expression of OTUD7B, TNIP2 and BAD decreased in HepG2 and Huh7 cells overexpressing miR-1180, and expression increased in cells transfected with the miR-1180 inhibitor compared to negative controls (XREF_FIG)."
26928365
reach
"Collectively, the results revealed that OTUD7B, TNIP2 and BAD are direct targets of miR-1180, and are subsequently downregulated in HCC cells overexpressing miR-1180."
26928365
OTUD7B activates miR-1180.
| 1
OTUD7B activates miR-1180. 1 / 1
| 1
reach
"Collectively, the results revealed that OTUD7B, TNIP2 and BAD are direct targets of miR-1180, and are subsequently downregulated in HCC cells overexpressing miR-1180."
26928365
OTUD7B inhibits cell differentiation. 2 / 2
| 2
reach
"Otud7b deficiency attenuated TCR-CD28-stimulated activation of Zap70 and downstream signaling factors and impaired T cell activation and Th1 cell differentiation."
26903241
reach
"In support, OTUD7B depletion in NSCs induces differentiation (71)."
35662507
OTUD7B activates cell differentiation.
| 2
reach
"Otud7b mediates T cell activation and differentiation in vitro."
26903241
reach
"COP1 knockdown stabilizes Sox2 and prevents differentiation, while OTUD7B knockdown destabilizes Sox2 and induces differentiation."
30405104
OTUD7B affects SHBG
| 1 3
SHBG binds OTUD7B and DiUb. 2 / 2
| 2
sparser
"A detailed analysis of internal K11-linked diUb ABP binding to Cezanne revealed that recognition of S1′ site ubiquitin leads to a large dynamic conformational change and subsequent catalysis in Cezanne."
| PMC
sparser
"A detailed analysis of internal K11-linked diUb ABP binding to Cezanne revealed that recognition of S1 0 site ubiquitin leads to a large dynamic conformational change and subsequent catalysis in Cezanne."
| PMC
SHBG binds OTUD7B. 1 / 1
| 1
sparser
"A detailed analysis of internal K11-linked diUb ABP binding to Cezanne revealed that recognition of S1′ site ubiquitin leads to a large dynamic conformational change and subsequent catalysis in Cezanne."
| PMC
SHBG binds OTUD7B and S1. 1 / 1
| 1
reach
"Furthermore, mutations in the S2 site using K48-linked diUb-AMC substrates showed a drastic reduction in hydrolysis supporting the importance of S2 site binding of distal Ub.A detailed analysis of internal K11-linked diUb ABP binding to Cezanne revealed that recognition of S1 0 site ubiquitin leads to a large dynamic conformational change and subsequent catalysis in Cezanne."
| PMC
OTUD7B affects MLST8
| 3 1
OTUD7B binds MLST8.
| 1 1
OTUD7B binds MLST8. 2 / 2
| 1 1
reach
"Reduced GbetaL ubiquitination was largely due to induced binding of OTUD7B to GbetaL, but not loss of TRAF2 binding (XREF_FIG and XREF_FIG)."
28489822
sparser
"Reduced GβL ubiquitination was largely due to induced binding of OTUD7B to GβL, but not loss of TRAF2 binding ( xref and xref )."
28489822
OTUD7B deubiquitinates MLST8.
| 1
OTUD7B leads to the deubiquitination of MLST8. 1 / 1
| 1
reach
"In addition, our integrative analysis demonstrates that ubiquitination of MLST8, which is reversed by OTUD7B, is regulated by IRS1/2."
34529665
OTUD7B activates MLST8.
| 1
OTUD7B activates MLST8. 1 / 1
| 1
reach
"Additionally, OTUD7B, but not UCH-L1, a DUB for RPTOR 24, targeted GbetaL for deubiquitination (XREF_FIG)."
28489822
OTUD7B affects K11
| 4
OTUD7B binds K11. 4 / 4
| 4
sparser
"S1–S1′ diUb ABPs have also successfully trapped and allowed the crystallization of the Cezanne-K11 diUb complex (Mevissen et al., 2016) and the OTULIN-Met1 diUb complex (Weber et al., 2017)."
30850058
sparser
"A K11 diUb probe was used to react with Cezanne to form a Cezanne-K11 diUb complex for crystallization."
34123237
sparser
"S1–S1′ diUb ABPs have also successfully trapped and allowed the crystallization of the Cezanne-K11 diUb complex ( xref ) and the OTULIN-Met1 diUb complex ( xref )."
30850058
sparser
"S1-S1 0 diUb ABPs have also successfully trapped and allowed the crystallization of the Cezanne-K11 diUb complex and the OTULIN-Met1 diUb complex (Weber et al., 2017) ."
30850058
EGFR affects OTUD7B
1 | 1 2
OTUD7B binds EGFR. 4 / 4
1 | 1 2
reach
"Subsequently, the interaction between OTUD7B and EGFR was confirmed by co-immunoprecipitation and immunofluorescent staining (Fig. 6b, c)."
31747939
sparser
"Subsequently, the interaction between OTUD7B and EGFR was confirmed by co-immunoprecipitation and immunofluorescent staining (Fig. xref b, c)."
31747939
biogrid
No evidence text available
22179831
sparser
"The results presented in xref confirmed that Cezanne-1 overexpression associates with remarkably reduced ubiquitination of EGFR, as well as with stabilization the receptor and an increase in auto-phosphorylation."
22179831
Sal-miR-1 and 3 affects OTUD7B
| 3
Sal-miR-1 and 3 decreases the amount of OTUD7B.
| 2
Sal-miR-1 and 3 decreases the amount of OTUD7B. 2 / 2
| 2
reach
"Together, these data indicate that Sal-miR-1 and 3 negatively regulate OTUD7B expression via directly targeting the 3 ' UTR of OTUD7B mRNA."
32685020
reach
"The results showed that stimulation of human VSMCs with thrombin could reduce NMHC IIA expression and enhance the expression of OTUD7B and KLF4, which could be largely reversed by transfecting Sal-miR-1 and 3 (XREF_SUPPLEMENTARY D)."
32685020
Sal-miR-1 and 3 increases the amount of OTUD7B.
| 1
Sal-miR-1 and 3 increases the amount of OTUD7B. 1 / 1
| 1
reach
"Because Sal-miR-1 and 3 downregulated KLF4 protein levels by attenuating OTUD7B expression, we sought to determine KLF4 target genes associated with induction of VSMC migration."
32685020
SOX2 affects OTUD7B
| 3
SOX2 binds OTUD7B and CREBZF. 2 / 2
| 2
sparser
"To further confirm the direct binding of Sox2 to OTUD7B ZF domain, we purified recombinant GST-tagged OTUD7B truncates, including GST-OTUD7B-N (1-359), GST-OTUD7B-C (360–843), GST-OTUD7B-△ZF (1–810), and GST-OTUD7B-ZF (811–843) (Fig.  xref )."
30405104
sparser
"The result of GST pull-down assay indicated that Sox2 interacted with OTUD7B ZF domain directly in cell-free system (Fig.  xref )."
30405104
SOX2 binds OTUD7B. 1 / 1
| 1
sparser
"Then we detected the interaction between Sox2 and OTUD7B at endogenous (Fig.  xref ) and exogenous (Supplementary Fig.  xref ) levels and mapped the Sox2-binding region of OTUD7B to the C-terminal zinc finger (ZF) domain (Fig.  xref )."
30405104
OTUD7B affects miR-500
| 3
OTUD7B activates miR-500. 3 / 3
| 3
reach
"Importantly, the repressive effect of antagomiR-500 on NF-kappaB activity and BCL2L1, CCND1 expression were potently antagonised by individual silencing of CYLD, TAX1BP1, or OTUD7B (XREF_SUPPLEMENTARY), indicating that CYLD, TAX1BP1, and OTUD7B are functionally relevant effectors of miR-500 in NF-kappaB activation."
25595906
reach
"Taken together, our results demonstrate that CYLD, TAX1BP1, and OTUD7B are bona fide targets of miR-500."
25595906
reach
"Using the TargetScan program, we found that CYLD, OTUD7B, and the A20 complex component TAX1BP1, which function as critical negative regulatory genes by deconjugating K63-polyubiquitin chains from RIP1 [XREF_BIBR, XREF_BIBR], might be potential targets of miR-500."
25595906
OTUD7B affects mTORC2
| 3
OTUD7B activates mTORC2. 3 / 3
| 3
reach
"As such it would be expected that both CUL4B-DDB1 and TRAF2 enhance mTORC1 dependent S6K and 4E-BP1 phosphorylation while UCH-L1 and OTUD7B enhance mTORC2 dependent AKT phosphorylation at S473.mTOR si[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28923280
reach
"Given that binding of p110alpha subunit to Ras and subsequent activation of PI3K is required for the development and maintenance of Kras driven lung tumours XREF_BIBR, XREF_BIBR, we further assessed whether Otud7b promoted mTORC2 and Akt signalling is causally related to Kras induced lung tumorigenesis."
28489822
reach
"Pathologically, OTUD7B mediated activation of mTORC2 and AKT signalling may be a critical molecular event down-stream of the RAS and PI3K pathway to favour Kras LA2 -driven lung tumorigenesis, suggesting that OTUD7B may be a potential therapeutic target against diseases harbouring hyperactivated PI3K and mTOR signalling such as cancer."
28489822
OTUD7B affects SQSTM1
| 2 1
OTUD7B deubiquitinates SQSTM1.
| 2
OTUD7B deubiquitinates SQSTM1. 2 / 2
| 2
reach
"OTUD7B deubiquitinates SQSTM1/p62 and promotes IRF3 degradation to regulate antiviral immunity."
35100065
reach
"OTUD7B deubiquitinates SQSTM1/p62 and promotes IRF3 degradation to regulate antiviral immunity."
35100065
OTUD7B binds SQSTM1.
| 1
SQSTM1 binds OTUD7B. 1 / 1
| 1
sparser
"LSD1 protein expression oscillates during cell cycle, low in G1 and high in G2/M. [ xref ] Similar expression patterns were observed with OTUD7B. [ xref ] We therefore set out to investigate if OTUD7B–p62 axis is responsible for LSD1 ubiquitination and degradation throughout the cell cycle."
34050636
OTUD7B affects SOX2
| 3
SOX2 binds OTUD7B and CREBZF. 2 / 2
| 2
sparser
"To further confirm the direct binding of Sox2 to OTUD7B ZF domain, we purified recombinant GST-tagged OTUD7B truncates, including GST-OTUD7B-N (1-359), GST-OTUD7B-C (360–843), GST-OTUD7B-△ZF (1–810), and GST-OTUD7B-ZF (811–843) (Fig.  xref )."
30405104
sparser
"The result of GST pull-down assay indicated that Sox2 interacted with OTUD7B ZF domain directly in cell-free system (Fig.  xref )."
30405104
SOX2 binds OTUD7B. 1 / 1
| 1
sparser
"Then we detected the interaction between Sox2 and OTUD7B at endogenous (Fig.  xref ) and exogenous (Supplementary Fig.  xref ) levels and mapped the Sox2-binding region of OTUD7B to the C-terminal zinc finger (ZF) domain (Fig.  xref )."
30405104
OTUD7B affects Neoplasm Metastasis
| 1 2
OTUD7B activates Neoplasm Metastasis.
| 2
OTUD7B activates Neoplasm Metastasis. 2 / 2
| 2
reach
"These results highlight a pivotal role of OTUD7B‐mediated deubiquitination of LSD1 in modulating its genomic occupancy and the regulation of gene transcription.2.7 OTUD7B Promotes Metastasis via LSD1."
34050636
reach
"These findings collectively identified OTUD7B as an independent predictive factor for the prognosis of non small cell lung cancer and revealed OTUD7B promotes lung cancer cell proliferation and metastasis via Akt and VEGF signal pathway."
31572671
OTUD7B inhibits Neoplasm Metastasis.
| 1
OTUD7B inhibits Neoplasm Metastasis. 1 / 1
| 1
eidos
"To investigate whether OTUD7B can inhibit LCL161 induced-invasion and metastasis in vivo , four groups of six mice each were administered 5 x 106 cells by intravenous tail vein injections ."
33198776
OTUD7B affects MMP9
| 3
OTUD7B binds MMP9. 3 / 3
| 3
sparser
"The results showed that Cezanne was negatively associated with MMP-9 in 230 HCC samples ( r  = −0.377, P  < 0.001, Figure  xref b)."
25638165
sparser
"Therefore, we also assessed the association of Cezanne with MMP-9 protein and investigated the prognostic value of Cezanne combined with serum AFP level in HCC patients."
25638165
sparser
"Moreover, Cezanne was negatively associated with MMP-9 among 230 HCC samples."
25638165
KLF4 affects OTUD7B
| 1 2
OTUD7B binds KLF4. 3 / 3
| 1 2
sparser
"The specificity of their interaction was verified by increased association of OTUD7B with KLF4 in OTUD7B-overexpressed cells (Figure xref G)."
32685020
sparser
"In the further study, we utilized co-immunoprecipitation experiments to examine the interaction of OTUD7B with KLF4 and found that KLF4 was co-immunoprecipitated by anti-OTUD7B antibody."
32685020
reach
"As anticipated, co-immunoprecipitation experiments revealed that OTUD7B interacted with and deubiquitylated KLF4."
32685020
FOXO4 affects OTUD7B
3 |
FOXO4 decreases the amount of OTUD7B. 3 / 3
3 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
Vasotocin affects OTUD7B
| 1 1
Vasotocin inhibits OTUD7B. 2 / 2
| 1 1
eidos
"As shown in Fig. 5d , AVT also decreases Otud4 , Otud5 and Otud7b in addition to Otub1 / c-Maf ."
33627137
reach
"XREF_FIG d, AVT also decreases Otud4, Otud5 and Otud7b in addition to Otub1 and c-Maf."
33627137
sparser
"These discoveries coincided with ROS-dependent inhibition of the DUB enzyme Cezanne in our current study."
31072419
Reactive oxygen species activates OTUD7B. 1 / 1
| 1
reach
"Given that Cezanne can be modulated by shear stress, TNFα, IL-1 and reactive oxygen species , future studies should address whether these factors influence inflammatory responses to hypoxia-reoxygenation by altering the expression and/or activity of Cezanne."
23564640
Phenylmercury acetate increases the amount of OTUD7B. 2 / 2
2 |
ctd
No evidence text available
26272509
ctd
No evidence text available
27188386
MiR-500 affects OTUD7B
| 2
MiR-500 inhibits OTUD7B. 2 / 2
| 2
reach
"Taken together, our results suggest that miR-500 overexpression activates the NF-kappaB signalling pathway by repressing CYLD, TAX1BP1, and OTUD7B, and consequently results in gastric cancer aggressiveness and poor clinical outcomes."
25595906
reach
"In gastric cancer cell lines, miR-500 directly repressed CYLD, OTUD7B, and the A20 complex component TAX1BP1 which led to sustained NF-kappaB activation [XREF_BIBR]."
28350359
MiR-1180 affects OTUD7B
| 2
MiR-1180 inhibits OTUD7B. 2 / 2
| 2
reach
"Moreover, we reveal that the miR-1180 directly targets two negative regulators of the nuclear factor (NF)-kappaB signaling pathway (OTUD7B and TNIP2) XREF_BIBR XREF_BIBR XREF_BIBR, as well as the pro apoptotic Bcl-2 associated death promoter (BAD) protein, via post-transcriptional downregulation."
26928365
reach
"In summary, the present study demonstrates that the upregulation of miR-1180 contributes to the proliferation and cisplatin-resistance of HCC cells both in vitro and in vivo, by targeting and suppressing OTUD7B, TNIP2 and BAD."
26928365
Hsa-miR-95-5p affects OTUD7B
2 |
Hsa-miR-95-5p decreases the amount of OTUD7B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-7846-3p affects OTUD7B
2 |
Hsa-miR-7846-3p decreases the amount of OTUD7B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6892-5p affects OTUD7B
2 |
Hsa-miR-6892-5p decreases the amount of OTUD7B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6878-5p affects OTUD7B
2 |
Hsa-miR-6878-5p decreases the amount of OTUD7B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-6760-5p affects OTUD7B
2 |
Hsa-miR-6760-5p decreases the amount of OTUD7B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-658 affects OTUD7B
2 |
Hsa-miR-658 decreases the amount of OTUD7B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-6134 affects OTUD7B
2 |
Hsa-miR-6134 decreases the amount of OTUD7B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23313552
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6079 affects OTUD7B
2 |
Hsa-miR-6079 decreases the amount of OTUD7B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23313552
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-5703 affects OTUD7B
2 |
Hsa-miR-5703 decreases the amount of OTUD7B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4799-5p affects OTUD7B
2 |
Hsa-miR-4799-5p decreases the amount of OTUD7B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4533 affects OTUD7B
2 |
Hsa-miR-4533 decreases the amount of OTUD7B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23313552
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4516 affects OTUD7B
2 |
Hsa-miR-4516 decreases the amount of OTUD7B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4475 affects OTUD7B
2 |
Hsa-miR-4475 decreases the amount of OTUD7B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4434 affects OTUD7B
2 |
Hsa-miR-4434 decreases the amount of OTUD7B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-154-5p affects OTUD7B
2 |
Hsa-miR-154-5p decreases the amount of OTUD7B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-107 affects OTUD7B
2 |
Hsa-miR-107 decreases the amount of OTUD7B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-103a-3p affects OTUD7B
2 |
Hsa-miR-103a-3p decreases the amount of OTUD7B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
Entinostat affects OTUD7B
2 |
Entinostat decreases the amount of OTUD7B. 2 / 2
2 |
ctd
No evidence text available
26272509
ctd
No evidence text available
27188386
Dorsomorphin affects OTUD7B
2 |
Dorsomorphin increases the amount of OTUD7B.
1 |
Dorsomorphin increases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
27188386
Dorsomorphin decreases the amount of OTUD7B.
1 |
Dorsomorphin decreases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
27188386
Dioxygen affects OTUD7B
| 1
Dioxygen activates OTUD7B. 1 / 2
| 1
reach
"The DUB Cezanne and OTUD7B is itself induced by oxygen deprivation in cultured endothelial cells."
30126257
Bisphenol A affects OTUD7B
2 |
Bisphenol A increases the amount of OTUD7B. 2 / 2
2 |
ctd
No evidence text available
28196854
ctd
No evidence text available
30816183
Benzo[a]pyrene affects OTUD7B
2 |
Benzo[a]pyrene increases the amount of OTUD7B. 2 / 2
2 |
ctd
No evidence text available
22228805
ctd
No evidence text available
21569818
Aflatoxin B1 affects OTUD7B
2 |
Aflatoxin B1 methylates OTUD7B.
1 |
Aflatoxin B1 methylates OTUD7B. 1 / 1
1 |
ctd
No evidence text available
30157460
Aflatoxin B1 increases the amount of OTUD7B.
1 |
Aflatoxin B1 increases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
19770486
ZEB1 affects OTUD7B
2 |
ZEB1 decreases the amount of OTUD7B. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
Ubiquitin affects OTUD7B
| 2
sparser
"DUB linkage specificity relies on careful positioning of the proximal Ub, which interacts with Cezanne via an unusual surface, involving Thr12, Glu16 and its α-helix (Asp32, Lys33, Glu34, Gly35) ( xref , xref )."
27732584
sparser
"Cezanne is hydroxylated at Asn35 of the UBA domain in an oxygen- or FIH1-dependent manner, which inhibits the binding of Ub to Cezanne ( xref )."
34177595
TFDP2 affects OTUD7B
2 |
TFDP2 decreases the amount of OTUD7B. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
SOX9 affects OTUD7B
2 |
SOX9 decreases the amount of OTUD7B. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
SOX2 affects CREBZF
| 2
SOX2 binds OTUD7B and CREBZF. 2 / 2
| 2
sparser
"To further confirm the direct binding of Sox2 to OTUD7B ZF domain, we purified recombinant GST-tagged OTUD7B truncates, including GST-OTUD7B-N (1-359), GST-OTUD7B-C (360–843), GST-OTUD7B-△ZF (1–810), and GST-OTUD7B-ZF (811–843) (Fig.  xref )."
30405104
sparser
"The result of GST pull-down assay indicated that Sox2 interacted with OTUD7B ZF domain directly in cell-free system (Fig.  xref )."
30405104
SHBG affects DiUb
| 2
SHBG binds OTUD7B and DiUb. 2 / 2
| 2
sparser
"A detailed analysis of internal K11-linked diUb ABP binding to Cezanne revealed that recognition of S1′ site ubiquitin leads to a large dynamic conformational change and subsequent catalysis in Cezanne."
| PMC
sparser
"A detailed analysis of internal K11-linked diUb ABP binding to Cezanne revealed that recognition of S1 0 site ubiquitin leads to a large dynamic conformational change and subsequent catalysis in Cezanne."
| PMC
PIK3R3 affects OTUD7B
2 |
OTUD7B binds PIK3R3. 2 / 2
2 |
biogrid
No evidence text available
25814554
biogrid
No evidence text available
25814554
PAX4 affects OTUD7B
2 |
PAX4 decreases the amount of OTUD7B. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
OTUD7B affects set1
| 2
OTUD7B leads to the methylation of set1. 2 / 2
| 2
reach
"Consequently, OTUD7B deficiency impairs genome-wide LSD1 occupancy and enhances the methylation of H3K4 and H3K9, therefore profoundly impacting global gene expression and abrogating breast cancer metastasis."
34050636
reach
"Consequently, OTUD7B deficiency impairs genome-wide LSD1 occupancy and enhances the methylation of H3K4/H3K9, therefore profoundly impacting global gene expression and abrogating breast cancer metastasis."
34050636
OTUD7B affects immune response
| 2
OTUD7B inhibits immune response. 2 / 2
| 2
reach
"Collectively, these findings suggest the intriguing possibility that inhibition of Otud7b may enhance mucosal immunity against C. rodentium infection."
23334419
reach
"The results described above prompted us to examine whether Otud7b negatively regulates mucosal immunity against infections."
23334419
OTUD7B affects activation
| 2
OTUD7B inhibits activation. 2 / 2
| 2
sparser
"In this current issue, Luong et al. report that Cezanne can also inhibit NF-κB-dependent inflammatory activation in response to hypoxia-reoxygenation by reducing TRAF6 K63 polyubiquitination."
23743222
sparser
"Because K11-linked polyubiquitin chains have been identified in the activated TNFR1 complex, these results imply that Cezanne may inhibit TNF-induced NF-κB activation by hydrolyzing K11-linked polyubiquitin chains on substrates present in the TNFR1 complex."
22435550
OTUD7B affects VEGF
| 2
OTUD7B activates VEGF. 2 / 2
| 2
reach
"ELISA and tube formation assay revealed OTUD7B promotes VEGF production and angiogenesis."
31572671
reach
"Upregulation of OTUD7B (Cezanne) Promotes Tumor Progression via AKT and VEGF Pathway in Lung Squamous Carcinoma and Adenocarcinoma."
31572671
OTUD7B affects TP53
| 2
OTUD7B inhibits TP53. 2 / 2
| 2
reach
"This verified that silencing OTUD7B and RTKN decreased p53 activity, suggesting that these genes encode p53 pathway enhancers."
28296343
reach
"XREF_FIG, two members of the OTU family, OTU6B and OTUD7B, significantly suppressed the transcriptional activity of p53."
29748582
OTUD7B affects TCR
| 2
OTUD7B inhibits TCR.
| 1
OTUD7B inhibits TCR. 1 / 1
| 1
reach
"Otud7b deficiency attenuated but did not completely block TCR signaling, consistent with partially impaired T cell activation and recall responses."
26903241
OTUD7B activates TCR.
| 1
Mutated OTUD7B activates TCR. 1 / 1
| 1
reach
"In contrast, Otud7b mutants harboring point mutations in its catalytic domain, C194S and H358N (CH), or lacking its N-terminal UBA domain (40-843) failed to rescue the TCR signaling events (XREF_FIG)."
26903241
OTUD7B affects Smac mimetic-induced lung cancer cell invasion
| 2
OTUD7B inhibits Smac mimetic-induced lung cancer cell invasion. 2 / 2
| 2
eidos
"OTUD7B suppresses Smac mimetic-induced lung cancer cell invasion and migration via deubiquitinating TRAF3 ."
33198776
eidos
"OTUD7B suppresses Smac mimetic-induced lung cancer cell invasion and migration via deubiquitinating TRAF3 Background Smac mimetics are a type of drug that can induce apoptosis by antagonizing IAP family members in cancer treatment ."
33198776
OTUD7B affects Sal-miR-1
| 2
OTUD7B activates Sal-miR-1. 2 / 2
| 2
reach
"Reversely, OTUD7B overexpression mediated by pcDNA3.1-OTUD7B partially blocked Sal-miR-1 and 3 inhibition of VSMC migration."
32685020
reach
"To further confirm whether OTUD7B is a direct target of Sal-miR-1 and 3, we co-transfected cells with Sal-miR-1 or Sal-miR-3 alone or together, both of which bind to the different sites on OTUD7B 3 ' UTR, along with OTUD7B 3 ' UTR- or its mutant (OTUD7B-MUT)-mediated luciferase reporter."
32685020
OTUD7B affects RNF8
| 2
OTUD7B inhibits RNF8. 2 / 2
| 2
reach
"To confirm that RNF8 promotes Lys11-linkage ubiquitin modification, we examined whether Cezanne, a DUB that specifically cleaves the Lys11-linkage ubiquitin conjugates, antagonizes the activity of RNF8 in Lys11-linkage ubiquitin modification of chromatin bound proteins."
28525740
reach
"To confirm that RNF8 promotes Lys11-linkage Ub modification, we examined whether Cezanne, a DUB that specifically cleaves the Lys11-linkage Ub conjugates (Bremm et al., 2010), antagonizes the activity[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28525740
OTUD7B activates Pancreatic Neoplasms. 2 / 2
| 2
reach
"The present study demonstrates that linc00976 enhances the proliferation and invasion ability of PC cells by upregulating OTUD7B expression, which was a target of miR-137."
31747939
reach
"However, the mechanism deubiquitinating enzyme OTUD7B promoted PC progress is not clear."
31747939
OTUD7B affects PIK3R3
2 |
OTUD7B binds PIK3R3. 2 / 2
2 |
biogrid
No evidence text available
25814554
biogrid
No evidence text available
25814554
OTUD7B affects OTUD7A
| 1 1
UBA1 binds OTUD7B, OTUD7A, and polyubiquitin. 1 / 1
| 1
sparser
"Using a ubiquitin binding domain protein array screen, we identify that the UBA domains of Cezanne and Cezanne2 (also known as Otud7A) selectively bind to Lys63-linked polyubiquitin."
31699778
OTUD7B binds OTUD7A. 1 / 1
| 1
reach
"Cezanne2 interacts with Cezanne, facilitating Cezanne in the recruitment of Rap80 and BRCA1-A, Rad18, and 53BP1, in cellular resistance to ionizing radiation and DNA repair."
31699778
OTUD7B affects NMHC IIA
| 2
OTUD7B inhibits NMHC IIA. 2 / 2
| 2
eidos
"Remarkably , Sal-miR-1 and 3 increased the expression levels of NMHC IIA by inhibiting OTUD7B expression and thus reducing KLF4 protein levels ."
32685020
eidos
"Together , these findings indicated that Sal-miR1 +3 enhance the expression levels of NMHC IIA gene by suppressing OTUD7B expression and thus reducing KLF4 protein levels ."
32685020
OTUD7B affects NFKB2
| 1 1
OTUD7B inhibits NFKB2.
| 1
OTUD7B inhibits NFKB2. 1 / 1
| 1
reach
"The de-ubiquitinating enzyme OTUD7B was also shown recently to potentially negatively regulate NF-kappaB2 (and primary B cell activation) by inhibiting activation induced degradation of TRAF3."
24298274
OTUD7B activates NFKB2.
| 1
OTUD7B activates NFKB2. 1 / 1
| 1
eidos
"We transfected HA-OTUD7B ( WT ) and HA-OTUD7B ( CH ) into H1299 cells and found that OTUD7B ( CH ) decreased the expression of TRAF3 and led to an increase in NIK and processing of p100 to p52 compared to that in the OTUD7B ( WT ) cells ( Fig. 6b ) ."
33198776
OTUD7B affects LCL161-induced lung cancer cell invasion
| 2
OTUD7B inhibits LCL161-induced lung cancer cell invasion. 2 / 2
| 2
eidos
"Furthermore , OTUD7B can inhibit LCL161-induced lung cancer cell invasion and migration by deubiquitinating TRAF3 , inhibiting NIK and preventing non-canonical NF-kappaB activation ."
33198776
eidos
"Consistently , OTUD7B ( WT ) but not OTUD7B ( CH ) inhibited activation of the non-canonical NF-kappaB pathway and LCL161-induced lung cancer cell invasion and migration ( Fig. 9 ) ."
33198776
OTUD7B affects LCL161-induced lung cancer cell intrapulmonary metastasis
| 2
OTUD7B inhibits LCL161-induced lung cancer cell intrapulmonary metastasis. 2 / 2
| 2
eidos
"OTUD7B inhibits LCL161-induced lung cancer cell intrapulmonary metastasis in vivo ."
33198776
eidos
"Finally , we investigated whether OTUD7B inhibits LCL161-induced lung cancer cell intrapulmonary metastasis in vivo , and our analysis of clinical samples was consistent with the above findings ."
33198776
OTUD7B affects LCL161-induced invasion
| 2
OTUD7B inhibits LCL161-induced invasion. 2 / 2
| 2
eidos
"Moreover , OTUD7B inhibits LCL161-induced invasion and migration by binding to and deubiquitinating TRAF3 , thereby inhibiting NIK and preventing non-canonical NF-kappaB activation ."
33198776
eidos
"However , whether OTUD7B can inhibit LCL161-induced invasion and migration and be used to select a target population in LCL161 treatment for lung cancer is unclear ."
33198776
OTUD7B affects KRAS
| 2
OTUD7B activates KRAS. 2 / 2
| 2
reach
"In support of a physiologically pivotal role for OTUD7B in the activation of mTORC2 and AKT signalling, genetic deletion of Otud7b in mice suppresses Akt activation and Kras driven lung tumorigenesis in vivo."
28489822
reach
"Second, OTUD7B amplifications were identified in a variety of cancers, including lung cancer, and homozygous deletion of Otud7b in the Kras LA2 lung cancer mouse model inhibited KRAS driven lung tumorigenesis 95."
29242641
OTUD7B affects Interferon
| 2
OTUD7B activates Interferon. 2 / 2
| 2
reach
"While young Otud7b-knockout mice had similar naive and memorylike T cells compared with wild-type mice, older mice deficient for CEZANNE had reduced IFNγ-producing T H 1 cell subsets 193 ."
28959952
reach
"While young Otud7b-knockout mice had similar naive and memory-like T cells compared with wild-type mice, older mice deficient for CEZANNE had reduced IFNγ-producing T 1 cell subsets ."
28959952
OTUD7B affects IRF3
| 1 1
OTUD7B inhibits IRF3.
| 1
OTUD7B inhibits IRF3. 1 / 1
| 1
eidos
"OTUD7B deubiquitinates SQSTM1 / p62 and promotes IRF3 degradation to regulate antiviral immunity ."
35100065
OTUD7B binds IRF3.
| 1
OTUD7B binds IRF3. 1 / 1
| 1
sparser
"Mechanistically, OTUD7B interacts with IRF3, and activates IRF3-associated cargo receptor SQSTM1/p62 (sequestosome 1) by removing its K63-linked poly-ubiquitin chains at lysine 7 (K7) to enhance SQSTM1 oligomerization."
35100065
OTUD7B affects IKK_complex
| 2
OTUD7B deubiquitinates IKK_complex.
| 1
OTUD7B leads to the deubiquitination of IKK_complex. 1 / 1
| 1
reach
"OTUD7B, a newly identified member of the A20 family of DUBs, inhibits RIP1 ubiquitination and downstream IKK activity and NF-kappaB signalling [XREF_BIBR]."
25595906
OTUD7B activates IKK_complex.
| 1
OTUD7B activates IKK_complex. 1 / 1
| 1
reach
"On the other hand, the Otud7b deficiency did not promote the activation of canonical IKK or MAP kinases (XREF_SUPPLEMENTARY), suggesting a specific role for Otud7b in noncanonical NF-kappaB regulation."
23334419
OTUD7B affects ICAM1
| 2
OTUD7B inhibits ICAM1.
| 1
OTUD7B inhibits ICAM1. 1 / 1
| 1
reach
"Silencing of Cezanne using a pool of siRNA sequences from an alternative source also significantly enhanced the induction of E-selectin, VCAM-1 and ICAM-1 in EC exposed to hypoxia-reoxygenation (Online Fig. VI)."
23564640
OTUD7B decreases the amount of ICAM1.
| 1
OTUD7B decreases the amount of ICAM1. 1 / 1
| 1
reach
"By contrast, silencing of Cezanne enhanced the expression of ICAM-1 in EC exposed to normoxia or hypoxia-reoxygenation (Fig. 3A, lower panel)."
23564640
OTUD7B affects HIF1AN
2 |
OTUD7B binds HIF1AN. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
OTUD7B affects H3K9
| 2
OTUD7B methylates H3K9.
| 1
OTUD7B leads to the methylation of H3K9. 1 / 1
| 1
reach
"Consequently, OTUD7B deficiency impairs genome-wide LSD1 occupancy and enhances the methylation of H3K4/H3K9, therefore profoundly impacting global gene expression and abrogating breast cancer metastasis."
34050636
OTUD7B demethylates H3K9.
| 1
OTUD7B leads to the demethylation of H3K9. 1 / 1
| 1
reach
"Consequently, OTUD7B deficiency impairs genome-wide LSD1 occupancy and enhances the methylation of H3K4 and H3K9, therefore profoundly impacting global gene expression and abrogating breast cancer metastasis."
34050636
OTUD7B affects H3K4me2
| 2
OTUD7B activates H3K4me2. 2 / 2
| 2
reach
"The fact that many of these gene hits are linked to cell cycle likely explains the result that the primary functions of OTUD7B or LSD1 in coordinating cell cycle progression.The above ChIP‐seq and RNA‐seq datasets were aligned to explore the potential correlations between OTUD7B‐induced H3K4me2 and LSD1 occupancy changes and changes in gene transcription."
34050636
reach
"Importantly, in LSD1‐reconstituted cells, LSD1 rendered their promoters resistant to OTUD7B ablation‐induced H3K4me2/H3K9me2 alterations (Figure 6J,L)."
34050636
OTUD7B affects ERK
| 2
OTUD7B phosphorylates ERK.
| 1
OTUD7B leads to the phosphorylation of ERK. 1 / 1
| 1
reach
"In vitro, overexpression of OTUD7B downregulated the phosphorylation level of FAK and then inhibited ERK/P38 phosphorylation, thus leading to decreased α-SMA and collagen Ⅰ expressions, while OTUD7B knockdown showed an opposite result."
35523269
OTUD7B dephosphorylates ERK.
| 1
OTUD7B leads to the dephosphorylation of ERK. 1 / 1
| 1
reach
"Otud7b deficiency inhibited TCR-CD28-stimulated phosphorylation of Zap70, Akt, and Erks in both naive CD4 + T cells (XREF_FIG) and naive CD8 + T cells (XREF_FIG)."
26903241
OTUD7B affects DiUb
| 2
SHBG binds OTUD7B and DiUb. 2 / 2
| 2
sparser
"A detailed analysis of internal K11-linked diUb ABP binding to Cezanne revealed that recognition of S1′ site ubiquitin leads to a large dynamic conformational change and subsequent catalysis in Cezanne."
| PMC
sparser
"A detailed analysis of internal K11-linked diUb ABP binding to Cezanne revealed that recognition of S1 0 site ubiquitin leads to a large dynamic conformational change and subsequent catalysis in Cezanne."
| PMC
OTUD7B affects CREBZF
| 2
SOX2 binds OTUD7B and CREBZF. 2 / 2
| 2
sparser
"To further confirm the direct binding of Sox2 to OTUD7B ZF domain, we purified recombinant GST-tagged OTUD7B truncates, including GST-OTUD7B-N (1-359), GST-OTUD7B-C (360–843), GST-OTUD7B-△ZF (1–810), and GST-OTUD7B-ZF (811–843) (Fig.  xref )."
30405104
sparser
"The result of GST pull-down assay indicated that Sox2 interacted with OTUD7B ZF domain directly in cell-free system (Fig.  xref )."
30405104
OTUD7B affects CD4
| 2
OTUD7B activates CD4. 2 / 2
| 2
reach
"Indeed, in vitro activated naive Otud7b -/- T cells produced less IL-2, and aged Otud7b deficient mice had increased frequencies and numbers of naive CD4 T cells, whereas those of effector-memory phenotype were decreased."
29685903
reach
"However, at an older age (12 mo old), the Otud7b -/- mice had significantly reduced frequency and absolute numbers of memory like T cells and concomitantly increased frequency and numbers of naive T cells in both CD4 + and CD8 + T cell populations (XREF_FIG)."
26903241
OTUD7B affects APC_C
| 2
APC_C binds OTUD7B. 2 / 2
| 2
sparser
"Accordingly, Cezanne binds established APC/C substrates and reverses their APC/C-mediated ubiquitination."
29973362
sparser
"Cezanne binds APC/C substrates, reverses their ubiquitination and protects them from degradation."
30874463
OTUD7B inhibitor affects OTUD7B
| 2
OTUD7B inhibitor inhibits OTUD7B.
| 1
OTUD7B inhibitor inhibits OTUD7B. 1 / 1
| 1
reach
"We validated the effects of the OTUD7B inhibitor (7Bi) in reducing Akt-pS473 signals in multiple NSCLC and HEK293 cells by blocking OTUD7B-governed GβL deubiquitination in cells, as well as inhibiting OTUD7B-mediated cleavage of K11-linked di-ub in an in vitro enzyme assay."
36672466
OTUD7B inhibitor activates OTUD7B.
| 1
OTUD7B inhibitor activates OTUD7B. 1 / 1
| 1
reach
"We validated the effects of the OTUD7B inhibitor (7Bi) in reducing Akt-pS473 signals in multiple NSCLC and HEK293 cells by blocking OTUD7B-governed GβL deubiquitination in cells, as well as inhibiting OTUD7B-mediated cleavage of K11-linked di-ub in an in vitro enzyme assay."
36672466
OTUD7A affects OTUD7B
| 1 1
UBA1 binds OTUD7B, OTUD7A, and polyubiquitin. 1 / 1
| 1
sparser
"Using a ubiquitin binding domain protein array screen, we identify that the UBA domains of Cezanne and Cezanne2 (also known as Otud7A) selectively bind to Lys63-linked polyubiquitin."
31699778
OTUD7B binds OTUD7A. 1 / 1
| 1
reach
"Cezanne2 interacts with Cezanne, facilitating Cezanne in the recruitment of Rap80 and BRCA1-A, Rad18, and 53BP1, in cellular resistance to ionizing radiation and DNA repair."
31699778
MLST8 affects OTUD7B
| 1 1
OTUD7B binds MLST8. 2 / 2
| 1 1
reach
"Reduced GbetaL ubiquitination was largely due to induced binding of OTUD7B to GbetaL, but not loss of TRAF2 binding (XREF_FIG and XREF_FIG)."
28489822
sparser
"Reduced GβL ubiquitination was largely due to induced binding of OTUD7B to GβL, but not loss of TRAF2 binding ( xref and xref )."
28489822
MAZ affects OTUD7B
2 |
MAZ decreases the amount of OTUD7B. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
MAP3K14 affects OTUD7B
| 2
TRAF3 binds OTUD7B and MAP3K14. 1 / 1
| 1
sparser
"Reciprocal co-immunoprecipitation was performed using anti-Flag anti-Myc and anti-HA antibodies to confirm whether OTUD7B directly binds to NIK or TRAF3."
33198776
OTUD7B binds MAP3K14. 1 / 1
| 1
sparser
"OTUD7B did not bind to NIK directly, but it did bind to TRAF3 (Fig.  xref a, b)."
33198776
Ischemia affects OTUD7B
| 2
Ischemia increases the amount of OTUD7B.
| 1
Ischemia increases the amount of OTUD7B. 1 / 1
| 1
reach
"Thus we conclude that ischemia induces local expression of Cezanne which protects the kidney from NF-κB-dependent inflammation and injury in response to reperfusion."
23564640
Ischemia activates OTUD7B.
| 1
Ischemia activates OTUD7B. 1 / 1
| 1
reach
"Similarly, ischemia induced Cezanne in the murine kidney in vascular EC, glomerular EC, podocytes and epithelial cells, and genetic deletion of Cezanne enhanced renal inflammation and injury in murine kidneys exposed to ischemia followed by reperfusion."
23564640
IL1 affects OTUD7B
| 2
IL1 activates OTUD7B. 2 / 2
| 2
reach
"Our subsequent studies revealed that Cezanne can be induced by TNFα, IL-1 and functions as an inhibitor of NF-κB, thus forming a negative feedback loop in inflammatory cytokine signalling , and a recent report indicated that Cezanne can also influence non-canonical NF-κB activation ."
23564640
reach
"Given that Cezanne can be modulated by shear stress, TNFα, IL-1 and reactive oxygen species , future studies should address whether these factors influence inflammatory responses to hypoxia-reoxygenation by altering the expression and/or activity of Cezanne."
23564640
HIF1AN affects OTUD7B
2 |
OTUD7B binds HIF1AN. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
HIF1A affects OTUD7B
1 | 1
OTUD7B binds EPAS1 and HIF1A. 1 / 1
| 1
sparser
"Finally, despite being inconsistent to its role in the regulation of HIF-1α and HIF-2α, decreased Cezanne expression is associated with the progression and poor prognosis in hepatocellular carcinoma ( xref )."
27014628
OTUD7B binds HIF1A. 1 / 1
1 |
biogrid
No evidence text available
25355043
FOXO1 affects OTUD7B
2 |
FOXO1 decreases the amount of OTUD7B. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
FOXF2 affects OTUD7B
2 |
FOXF2 decreases the amount of OTUD7B. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
E2F4 affects OTUD7B
2 |
E2F4 decreases the amount of OTUD7B. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
DiUb affects SHBG
| 2
SHBG binds OTUD7B and DiUb. 2 / 2
| 2
sparser
"A detailed analysis of internal K11-linked diUb ABP binding to Cezanne revealed that recognition of S1′ site ubiquitin leads to a large dynamic conformational change and subsequent catalysis in Cezanne."
| PMC
sparser
"A detailed analysis of internal K11-linked diUb ABP binding to Cezanne revealed that recognition of S1 0 site ubiquitin leads to a large dynamic conformational change and subsequent catalysis in Cezanne."
| PMC
Cuprizone affects OTUD7B
2 |
Cuprizone decreases the amount of OTUD7B. 2 / 2
2 |
ctd
No evidence text available
26577399
ctd
No evidence text available
27523638
CREBZF affects SOX2
| 2
SOX2 binds OTUD7B and CREBZF. 2 / 2
| 2
sparser
"To further confirm the direct binding of Sox2 to OTUD7B ZF domain, we purified recombinant GST-tagged OTUD7B truncates, including GST-OTUD7B-N (1-359), GST-OTUD7B-C (360–843), GST-OTUD7B-△ZF (1–810), and GST-OTUD7B-ZF (811–843) (Fig.  xref )."
30405104
sparser
"The result of GST pull-down assay indicated that Sox2 interacted with OTUD7B ZF domain directly in cell-free system (Fig.  xref )."
30405104
ATF2 affects OTUD7B
| 2
ATF2 increases the amount of OTUD7B.
| 1
ATF2 increases the amount of OTUD7B. 1 / 1
| 1
reach
"Thus we conclude that ATF2 positively regulates Cezanne expression in hypoxic EC."
23564640
ATF2 activates OTUD7B.
| 1
ATF2 activates OTUD7B. 1 / 1
| 1
reach
"We observed that silencing of ATF2 using two different siRNA sequences suppressed the induction of Cezanne by hypoxia (Fig. 2B)."
23564640
APC_C affects OTUD7B
| 2
APC_C binds OTUD7B. 2 / 2
| 2
sparser
"Accordingly, Cezanne binds established APC/C substrates and reverses their APC/C-mediated ubiquitination."
29973362
sparser
"Cezanne binds APC/C substrates, reverses their ubiquitination and protects them from degradation."
30874463
Viral process affects OTUD7B
| 1
eidos
"Moreover , viral infection increased the expression of OTUD7B , which forms a negative feedback loop by promoting IRF3 degradation to balance type I interferon ( IFN ) signaling ."
35100065
Valproic acid affects OTUD7B
1 |
Valproic acid increases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
21427059
VIRF-2 affects OTUD7B
| 1
VIRF-2 ubiquitinates OTUD7B. 1 / 1
| 1
sparser
"Multiple DUBs from the human ovarian tumor (OTU) DUB family that display various degrees of specificities towards different ubiquitin linkage types have been identified and can be used for UbiCRest: For instance, OTUB1 specifically cleaves K48-, OTUD1 K63-, Cezanne K11-, and OTULIN M1-linked ubiquitylation, whereas OTUD3 displays specificity towards K6- and K11-linked ubiquitylation ( xref )."
27379159
Urethane affects OTUD7B
1 |
Urethane increases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
28818685
Tungsten affects OTUD7B
1 |
Tungsten decreases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
30912803
Troglitazone affects OTUD7B
1 |
Troglitazone decreases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
28973697
Trichloroethene affects OTUD7B
1 |
Trichloroethene increases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
25549359
Thiram affects OTUD7B
1 |
Thiram decreases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
20530235
Testosterone affects OTUD7B
1 |
Testosterone increases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
21592394
Removal exons insertion splice acceptor site affects OTUD7B
| 1
Removal exons insertion splice acceptor site inhibits OTUD7B. 1 / 1
| 1
eidos
"Transgenic ' gene-trapped ' ( GT ) mice22 in which the Cezanne gene is disrupted by removal of exons 4-7 and insertion of a splice acceptor site , LacZ open reading frame , neomycin resistance gene ( Neo ) and polyA tail in the third intron ( B6-Otud7btml ( NCOM ) Cmhd ; CezanneGT / GT ; C57BL / 6 background ) were obtained from the Canadian Mouse Mutant Repository ."
23564640
Pregnenolone 16alpha-carbonitrile decreases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
28903501
Polyubiquitin affects UBA1
| 1
UBA1 binds OTUD7B, OTUD7A, and polyubiquitin. 1 / 1
| 1
sparser
"Using a ubiquitin binding domain protein array screen, we identify that the UBA domains of Cezanne and Cezanne2 (also known as Otud7A) selectively bind to Lys63-linked polyubiquitin."
31699778
Pirinixic acid affects OTUD7B
1 |
Pirinixic acid increases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
18301758
PcDNA3.1-OTUD7B affects OTUD7B
| 1
PcDNA3.1-OTUD7B decreases the amount of OTUD7B. 1 / 1
| 1
reach
"Reversely, OTUD7B overexpression mediated by pcDNA3.1-OTUD7B partially blocked Sal-miR-1 and 3 inhibition of VSMC migration."
32685020
Nickel monoxide affects OTUD7B
1 |
Nickel monoxide decreases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
19167457
Nickel atom affects OTUD7B
1 |
Nickel atom decreases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
25583101
Naphthoquinone affects OTUD7B
1 |
Naphthoquinone increases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
23811387
Midostaurin affects OTUD7B
1 |
Midostaurin decreases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
20980353
MiR-486-5p affects OTUD7B
| 1
MiR-486-5p inhibits OTUD7B. 1 / 1
| 1
eidos
"miR-486-5p not only targets neuropilin 2 ( NRP2 ) encoding inflammatory inhibitor neuropilin-2 , but also represses OTUD7B to induce excessive inflammation in lung 26 , 27 , 28 ( Figure 2F ) ."
| PMC
MiR-146a-5p affects OTUD7B
| 1
MiR-146a-5p activates OTUD7B. 1 / 1
| 1
reach
"Downregulation of miR-146a-5p inhibits choroidal neovascularization via the NF-kappaB signaling pathway by targeting OTUD7B."
32438838
MiR-137 affects OTUD7B
| 1
MiR-137 increases the amount of OTUD7B. 1 / 1
| 1
isi
"The present study demonstrates that linc00976 enhances the proliferation and invasion ability of PC cells by upregulating OTUD7B expression, which was a target of miR-137."
31747939
Methapyrilene affects OTUD7B
1 |
Methapyrilene methylates OTUD7B. 1 / 1
1 |
ctd
No evidence text available
30157460
Linc00976 affects OTUD7B
| 1
Linc00976 increases the amount of OTUD7B. 1 / 1
| 1
isi
"The present study demonstrates that linc00976 enhances the proliferation and invasion ability of PC cells by upregulating OTUD7B expression, which was a target of miR-137."
31747939
Hsa-miR-939-3p affects OTUD7B
1 |
Hsa-miR-939-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-92b-3p affects OTUD7B
1 |
Hsa-miR-92b-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-92a-3p affects OTUD7B
1 |
Hsa-miR-92a-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-877-5p affects OTUD7B
1 |
Hsa-miR-877-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-8077 affects OTUD7B
1 |
Hsa-miR-8077 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-8063 affects OTUD7B
1 |
Hsa-miR-8063 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-7977 affects OTUD7B
1 |
Hsa-miR-7977 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-7854-3p affects OTUD7B
1 |
Hsa-miR-7854-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-7850-5p affects OTUD7B
1 |
Hsa-miR-7850-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-7703 affects OTUD7B
1 |
Hsa-miR-7703 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-767-5p affects OTUD7B
1 |
Hsa-miR-767-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-766-3p affects OTUD7B
1 |
Hsa-miR-766-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-7162-3p affects OTUD7B
1 |
Hsa-miR-7162-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-7160-5p affects OTUD7B
1 |
Hsa-miR-7160-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-6880-5p affects OTUD7B
1 |
Hsa-miR-6880-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6874-5p affects OTUD7B
1 |
Hsa-miR-6874-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6860 affects OTUD7B
1 |
Hsa-miR-6860 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6851-5p affects OTUD7B
1 |
Hsa-miR-6851-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6849-3p affects OTUD7B
1 |
Hsa-miR-6849-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6847-3p affects OTUD7B
1 |
Hsa-miR-6847-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-6811-3p affects OTUD7B
1 |
Hsa-miR-6811-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-6771-3p affects OTUD7B
1 |
Hsa-miR-6771-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-6721-5p affects OTUD7B
1 |
Hsa-miR-6721-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6720-5p affects OTUD7B
1 |
Hsa-miR-6720-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-661 affects OTUD7B
1 |
Hsa-miR-661 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6516-5p affects OTUD7B
1 |
Hsa-miR-6516-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-6514-3p affects OTUD7B
1 |
Hsa-miR-6514-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-6512-3p affects OTUD7B
1 |
Hsa-miR-6512-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6500-5p affects OTUD7B
1 |
Hsa-miR-6500-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6499-3p affects OTUD7B
1 |
Hsa-miR-6499-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-638 affects OTUD7B
1 |
Hsa-miR-638 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-616-5p affects OTUD7B
1 |
Hsa-miR-616-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6133 affects OTUD7B
1 |
Hsa-miR-6133 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6130 affects OTUD7B
1 |
Hsa-miR-6130 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6129 affects OTUD7B
1 |
Hsa-miR-6129 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-612 affects OTUD7B
1 |
Hsa-miR-612 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-587 affects OTUD7B
1 |
Hsa-miR-587 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-5708 affects OTUD7B
1 |
Hsa-miR-5708 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-548s affects OTUD7B
1 |
Hsa-miR-548s decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-5189-5p affects OTUD7B
1 |
Hsa-miR-5189-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-513c-3p affects OTUD7B
1 |
Hsa-miR-513c-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-513b-5p affects OTUD7B
1 |
Hsa-miR-513b-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-513a-3p affects OTUD7B
1 |
Hsa-miR-513a-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-508-5p affects OTUD7B
1 |
Hsa-miR-508-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-500a-5p affects OTUD7B
1 |
Hsa-miR-500a-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
25595906
Hsa-miR-500a-3p affects OTUD7B
1 |
Hsa-miR-500a-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4793-3p affects OTUD7B
1 |
Hsa-miR-4793-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4765 affects OTUD7B
1 |
Hsa-miR-4765 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4756-5p affects OTUD7B
1 |
Hsa-miR-4756-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4739 affects OTUD7B
1 |
Hsa-miR-4739 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4733-5p affects OTUD7B
1 |
Hsa-miR-4733-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4698 affects OTUD7B
1 |
Hsa-miR-4698 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4684-5p affects OTUD7B
1 |
Hsa-miR-4684-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-4663 affects OTUD7B
1 |
Hsa-miR-4663 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4633-3p affects OTUD7B
1 |
Hsa-miR-4633-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-455-3p affects OTUD7B
1 |
Hsa-miR-455-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4537 affects OTUD7B
1 |
Hsa-miR-4537 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4510 affects OTUD7B
1 |
Hsa-miR-4510 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4478 affects OTUD7B
1 |
Hsa-miR-4478 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-4457 affects OTUD7B
1 |
Hsa-miR-4457 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4419b affects OTUD7B
1 |
Hsa-miR-4419b decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-4419a affects OTUD7B
1 |
Hsa-miR-4419a decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4284 affects OTUD7B
1 |
Hsa-miR-4284 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-4282 affects OTUD7B
1 |
Hsa-miR-4282 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-3929 affects OTUD7B
1 |
Hsa-miR-3929 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-3926 affects OTUD7B
1 |
Hsa-miR-3926 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-383-3p affects OTUD7B
1 |
Hsa-miR-383-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-373-5p affects OTUD7B
1 |
Hsa-miR-373-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-371b-5p affects OTUD7B
1 |
Hsa-miR-371b-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-3689d affects OTUD7B
1 |
Hsa-miR-3689d decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-3675-3p affects OTUD7B
1 |
Hsa-miR-3675-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-367-3p affects OTUD7B
1 |
Hsa-miR-367-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-363-3p affects OTUD7B
1 |
Hsa-miR-363-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-3606-3p affects OTUD7B
1 |
Hsa-miR-3606-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-339-5p affects OTUD7B
1 |
Hsa-miR-339-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-3202 affects OTUD7B
1 |
Hsa-miR-3202 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-32-5p affects OTUD7B
1 |
Hsa-miR-32-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-3190-5p affects OTUD7B
1 |
Hsa-miR-3190-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-3187-5p affects OTUD7B
1 |
Hsa-miR-3187-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-3160-3p affects OTUD7B
1 |
Hsa-miR-3160-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-25-3p affects OTUD7B
1 |
Hsa-miR-25-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-24-3p affects OTUD7B
1 |
Hsa-miR-24-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-218-5p affects OTUD7B
1 |
Hsa-miR-218-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
24501422
Hsa-miR-214-5p affects OTUD7B
1 |
Hsa-miR-214-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-19b-3p affects OTUD7B
1 |
Hsa-miR-19b-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-19a-3p affects OTUD7B
1 |
Hsa-miR-19a-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-16-5p affects OTUD7B
1 |
Hsa-miR-16-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-1321 affects OTUD7B
1 |
Hsa-miR-1321 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-1292-3p affects OTUD7B
1 |
Hsa-miR-1292-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-1285-3p affects OTUD7B
1 |
Hsa-miR-1285-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-1273g-3p affects OTUD7B
1 |
Hsa-miR-1273g-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-125b-2-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-1236-5p affects OTUD7B
1 |
Hsa-miR-1236-5p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-1229-3p affects OTUD7B
1 |
Hsa-miR-1229-3p decreases the amount of OTUD7B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Furan affects OTUD7B
1 |
Furan increases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
24183702
Ethanol affects OTUD7B
1 |
Ethanol increases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
30319688
Doxorubicin affects OTUD7B
1 |
Doxorubicin decreases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
29803840
Disulfiram affects OTUD7B
1 |
Disulfiram decreases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
20530235
Dibutyl phthalate increases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
21266533
Decabromodiphenyl ether increases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
23640034
Curcumin affects OTUD7B
1 |
Curcumin decreases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
18421014
Chlorpyrifos affects OTUD7B
1 |
Chlorpyrifos increases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
20350560
Calcitriol affects OTUD7B
1 |
Calcitriol increases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
21592394
Butanal affects OTUD7B
1 |
Butanal decreases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
26079696
Benzo[e]pyrene affects OTUD7B
1 |
Benzo[e]pyrene methylates OTUD7B. 1 / 1
1 |
ctd
No evidence text available
30157460
Atrazine affects OTUD7B
1 |
Atrazine increases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
22378314
Anti-LTbetaR affects OTUD7B
| 1
Anti-LTbetaR activates OTUD7B. 1 / 1
| 1
reach
"The Otud7b deficiency greatly enhanced the NF-kappaB activation by agonistic anti-LTbetaR and anti-CD40 antibodies or BAFF (XREF_FIG), a result that was not due to differential expression of the receptors (XREF_SUPPLEMENTARY)."
23334419
Anti-CD40 antibodies affects OTUD7B
| 1
Anti-CD40 antibodies activates OTUD7B. 1 / 1
| 1
reach
"The Otud7b deficiency greatly enhanced the NF-kappaB activation by agonistic anti-LTbetaR and anti-CD40 antibodies or BAFF (XREF_FIG), a result that was not due to differential expression of the receptors (XREF_SUPPLEMENTARY)."
23334419
All-trans-retinoic acid increases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
20488242
Activation NF-kappaB affects OTUD7B
| 1
Activation NF-kappaB activates OTUD7B. 1 / 1
| 1
eidos
"Under low LSS , the activation of NF-kappaB induces elevated HIF-1alpha mRNA and increased the expression of cezanne , a ubiquitin-editing enzyme preventing the HIF-1alpha protein degradation , thus stabilizing HIF-1alpha ."
33681205
Abrine affects OTUD7B
1 |
Abrine increases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
31054353
ZRANB1 affects TRAF6
| 1
TRAF6 binds OTUD7B and ZRANB1. 1 / 1
| 1
sparser
"Co-immunoprecipitation studies indicated that TRAF6 was able to interact with both Cezanne and TRABID."
11463333
ZDHHC17 affects OTUD7B
1 |
OTUD7B binds ZDHHC17. 1 / 1
1 |
biogrid
No evidence text available
24705354
ZAP70 affects USP9X
| 1
USP9X binds ZAP70 and OTUD7B. 1 / 1
| 1
sparser
"Unlike Otud7b, USP9X does not directly interact with Zap70 but rather comes into the proximity of Zap70 via interaction with a LAT signaling complex [ xref ]."
30054854
ZAP70 affects Sts1/2
| 1
ZAP70 binds OTUD7B and Sts1/2. 1 / 1
| 1
sparser
"Collectively, these data suggest that the enhanced interaction between Zap70 and Sts1/2 in Otud7b-deficient T cells contributes to attenuated Zap70 activation and TCR signaling."
26903241
XPO1 affects OTUD7B
1 |
XPO1 binds OTUD7B. 1 / 1
1 |
biogrid
No evidence text available
21888622
WWP2 affects OTUD7B
1 |
OTUD7B binds WWP2. 1 / 1
1 |
biogrid
No evidence text available
25071155
WWOX affects OTUD7B
1 |
WWOX binds OTUD7B. 1 / 1
1 |
biogrid
No evidence text available
24550385
WIPI1 affects OTUD7B
| 1
OTUD7B binds WIPI1. 1 / 1
| 1
sparser
"An equivalent catalytically inactive mutant of the closely related DUB Cezanne does not form puncta upon overexpression ( xref ), suggesting that the propensity to form dynamic protein assemblies is not a general property of catalytically inactive OTU family proteins."
22157957
VSX1 affects OTUD7B
1 |
VSX1 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:msigdb
No evidence text available
VDR affects OTUD7B
1 |
VDR decreases the amount of OTUD7B. 1 / 1
1 |
biopax:msigdb
No evidence text available
USP9X affects ZAP70
| 1
USP9X binds ZAP70 and OTUD7B. 1 / 1
| 1
sparser
"Unlike Otud7b, USP9X does not directly interact with Zap70 but rather comes into the proximity of Zap70 via interaction with a LAT signaling complex [ xref ]."
30054854
USP28 affects OTUD7B
| 1
USP28 binds OTUD7B. 1 / 1
| 1
reach
"In addition to USP22 and USP28, ectopic OTUD7B also bound robustly to endogenous LSD1 (Figure  1A )."
34050636
USP22 affects OTUD7B
| 1
USP22 binds OTUD7B. 1 / 1
| 1
reach
"In addition to USP22 and USP28, ectopic OTUD7B also bound robustly to endogenous LSD1 (Figure  1A )."
34050636
US7 affects OTUD7B
1 |
OTUD7B binds US7. 1 / 1
1 |
virhostnet
No evidence text available
31873071
UBE2S affects OTUD7B
1 |
OTUD7B binds UBE2S. 1 / 1
1 |
biogrid
No evidence text available
20622874
UBA1 affects polyubiquitin
| 1
UBA1 binds OTUD7B, OTUD7A, and polyubiquitin. 1 / 1
| 1
sparser
"Using a ubiquitin binding domain protein array screen, we identify that the UBA domains of Cezanne and Cezanne2 (also known as Otud7A) selectively bind to Lys63-linked polyubiquitin."
31699778
TRAF6 affects ZRANB1
| 1
TRAF6 binds OTUD7B and ZRANB1. 1 / 1
| 1
sparser
"Co-immunoprecipitation studies indicated that TRAF6 was able to interact with both Cezanne and TRABID."
11463333
TRAF3 affects MAP3K14
| 1
TRAF3 binds OTUD7B and MAP3K14. 1 / 1
| 1
sparser
"Reciprocal co-immunoprecipitation was performed using anti-Flag anti-Myc and anti-HA antibodies to confirm whether OTUD7B directly binds to NIK or TRAF3."
33198776
TNFSF13B affects OTUD7B
| 1
TNFSF13B activates OTUD7B. 1 / 1
| 1
reach
"The Otud7b deficiency greatly enhanced the NF-kappaB activation by agonistic anti-LTbetaR and anti-CD40 antibodies or BAFF (XREF_FIG), a result that was not due to differential expression of the receptors (XREF_SUPPLEMENTARY)."
23334419
TNFRSF13C affects OTUD7B
| 1
TNFRSF13C activates OTUD7B. 1 / 1
| 1
eidos
"Activation of BAFFR increases OTUD7B expression and the newly synthesized deubiquitinase then binds to TRAF3 resulting in the formation of a high molecular weight complex including OTUDB7 , TRAF3 , TRAF2 , and cIAP1 / 2 ."
30349534
TFAP2C affects OTUD7B
1 |
TFAP2C decreases the amount of OTUD7B. 1 / 1
1 |
biopax:msigdb
No evidence text available
TCF3 affects OTUD7B
1 |
TCF3 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:msigdb
No evidence text available
TAX1BP1 affects OTUD7B
| 1
TAX1BP1 binds OTUD7B and CYLD. 1 / 1
| 1
sparser
"As the inhibitory effect of CYLD, TAX1BP1, and OTUD7B on NF-ĸB activation are associated with deconjugation of K63-polyubiquitin chains from RIP1 [ xref , xref , xref ], we then examined the effect of miR-500 on the ubiquitination status of RIP1."
25595906
Sts1/2 affects ZAP70
| 1
ZAP70 binds OTUD7B and Sts1/2. 1 / 1
| 1
sparser
"Collectively, these data suggest that the enhanced interaction between Zap70 and Sts1/2 in Otud7b-deficient T cells contributes to attenuated Zap70 activation and TCR signaling."
26903241
Sal-miR1 affects OTUD7B
| 1
Sal-miR1 decreases the amount of OTUD7B. 1 / 1
| 1
reach
"Together, these findings indicated that Sal-miR1 +3 enhance the expression levels of NMHC IIA gene by suppressing OTUD7B expression and thus reducing KLF4 protein levels."
32685020
Sal-miR-3 affects OTUD7B
| 1
Sal-miR-3 decreases the amount of OTUD7B. 1 / 1
| 1
reach
"Next, we confirmed that Sal-miR-1 or Sal-miR-3 alone or together significantly inhibited the expression of OTUD7B mRNA and protein, but did not affect KLF3 and KLF10 expression, indicating the specificity of these two miRNA target recognition (XREF_SUPPLEMENTARY B-C)."
32685020
SRY affects OTUD7B
1 |
SRY decreases the amount of OTUD7B. 1 / 1
1 |
biopax:msigdb
No evidence text available
SQSTM1 affects OTUD7B
| 1
SQSTM1 binds OTUD7B. 1 / 1
| 1
sparser
"LSD1 protein expression oscillates during cell cycle, low in G1 and high in G2/M. [ xref ] Similar expression patterns were observed with OTUD7B. [ xref ] We therefore set out to investigate if OTUD7B–p62 axis is responsible for LSD1 ubiquitination and degradation throughout the cell cycle."
34050636
SP1 affects OTUD7B
1 |
SP1 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:msigdb
No evidence text available
SLC9A3R2 affects OTUD7B
1 |
SLC9A3R2 binds OTUD7B. 1 / 1
1 |
biogrid
No evidence text available
19615732
SHBG affects S1
| 1
SHBG binds OTUD7B and S1. 1 / 1
| 1
reach
"Furthermore, mutations in the S2 site using K48-linked diUb-AMC substrates showed a drastic reduction in hydrolysis supporting the importance of S2 site binding of distal Ub.A detailed analysis of internal K11-linked diUb ABP binding to Cezanne revealed that recognition of S1 0 site ubiquitin leads to a large dynamic conformational change and subsequent catalysis in Cezanne."
| PMC
S-2-pentyl-4-pentynoic hydroxamic acid increases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
21427059
reach
"Thus we conclude that ischemia-reperfusion induces Cezanne in multiple cell types in the kidney including EC."
23564640
RXRB affects OTUD7B
1 |
RXRB decreases the amount of OTUD7B. 1 / 1
1 |
biopax:msigdb
No evidence text available
RIPK1 affects PARK7
| 1
RIPK1 binds PARK7 and OTUD7B. 1 / 1
| 1
sparser
"Cezanne interacts with DJ-1 and targets RIPK1 signaling intermediates, thereby suppressing NF-κB nuclear translocation and its activity [ xref , xref ]."
32549302
RFX1 affects OTUD7B
1 |
RFX1 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:msigdb
No evidence text available
RCOR1 affects OTUD7B
| 1
OTUD7B binds RCOR1. 1 / 1
| 1
reach
"Notably, we were unable to detect any significant interaction between OTUD7B and CoREST when both were ectopically expressed, even in cells expressing ectopic LSD1 (Figure S1E, Supporting Information)."
34050636
RB1 affects OTUD7B
1 |
RB1 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:msigdb
No evidence text available
Proteasome affects OTUD7B
| 1
Proteasome activates OTUD7B. 1 / 1
| 1
reach
"It was reported that Lys11 modified APC/C substrates are targeted for proteasomal degradation XREF_BIBR, XREF_BIBR, but surprisingly, inhibition of the proteasome by MG132 or epoxomicin, which efficiently stabilised HIF-1alpha protein levels, did not rescue the effect of Cezanne knockdown on HIF-1alpha (Fig XREF_FIG B, Supplementary Fig S4A and C)."
25355043
PPARA affects OTUD7B
1 |
PPARA decreases the amount of OTUD7B. 1 / 1
1 |
biopax:msigdb
No evidence text available
POU6F1 affects OTUD7B
1 |
POU6F1 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:msigdb
No evidence text available
POU2F1 affects OTUD7B
1 |
POU2F1 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:msigdb
No evidence text available
POU1F1 affects OTUD7B
1 |
POU1F1 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:msigdb
No evidence text available
PI3K/AKT/mTOR affects OTUD7B
| 1
PI3K/AKT/mTOR activates OTUD7B. 1 / 1
| 1
reach
"Mechanistically, the overexpression of Cezanne significantly reversed the in-activation of the PI3K/AKT/mTOR pathway induced by DOX, while the inhibitors of this pathway abolished the effect of Cezanne, suggesting that the PI3K/AKT/mTOR pathway plays a role in the protective function of Cezanne."
36639017
PCB 180 affects OTUD7B
1 |
PCB 180 decreases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
23829299
PAX5 affects OTUD7B
1 |
PAX5 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:msigdb
No evidence text available
PARK7 affects RIPK1
| 1
RIPK1 binds PARK7 and OTUD7B. 1 / 1
| 1
sparser
"Cezanne interacts with DJ-1 and targets RIPK1 signaling intermediates, thereby suppressing NF-κB nuclear translocation and its activity [ xref , xref ]."
32549302
OTULIN affects OTUD7B
| 1
OTULIN ubiquitinates OTUD7B. 1 / 1
| 1
sparser
"Multiple DUBs from the human ovarian tumor (OTU) DUB family that display various degrees of specificities towards different ubiquitin linkage types have been identified and can be used for UbiCRest: For instance, OTUB1 specifically cleaves K48-, OTUD1 K63-, Cezanne K11-, and OTULIN M1-linked ubiquitylation, whereas OTUD3 displays specificity towards K6- and K11-linked ubiquitylation ( xref )."
27379159
OTUD7B affects ubiquitination
| 1
OTUD7B inhibits ubiquitination. 1 / 1
| 1
sparser
"Otud7b likely opposes the action of a Zap70 E3 ligase other than Nrdp1, because Otud7b inhibits Zap70 ubiquitination mainly at K544, which differs from the Nrdp1 target site (K538)."
26903241
OTUD7B affects transduction
| 1
reach
"Thus, USP12 and OTUD7B counterbalance inhibitory E3 ligases to stabilize TCR signaling.Aside from acting at the proximal signalosome, E3 ligases also inhibit T-cell activation by acting further downstream, controlling the key transduction events that lead to the nuclear translocation of the T-cell activating transcription factors."
| PMC
OTUD7B activates transcription, DNA-templated. 1 / 1
| 1
reach
"Consistently, the loss of Otud7b inhibited the activation of three major downstream transcription factors involved in T cell activation, NF-kappaB, NF-AT, and AP1 (XREF_FIG)."
26903241
OTUD7B affects signaling
| 1
OTUD7B inhibits signaling. 1 / 1
| 1
sparser
"Together, the data from these studies indicate that Cezanne can inhibit canonical NF-κB signaling through the de-ubiquitination of TRAF6 both in vitro and in vivo ( xref )."
29389019
OTUD7B affects required VHL
| 1
OTUD7B activates required VHL. 1 / 1
| 1
eidos
"Further , the effects of OTUD7B on HIF-1alpha were not dependent on PHD-mediated HIF-1alpha hydroxylation , but required VHL ."
31208103
OTUD7B affects polyubiquitin
| 1
UBA1 binds OTUD7B, OTUD7A, and polyubiquitin. 1 / 1
| 1
sparser
"Using a ubiquitin binding domain protein array screen, we identify that the UBA domains of Cezanne and Cezanne2 (also known as Otud7A) selectively bind to Lys63-linked polyubiquitin."
31699778
OTUD7B affects polyubiquitin chains
| 1
OTUD7B inhibits polyubiquitin chains. 1 / 1
| 1
reach
"Thus Cezanne suppresses activation of NF-κB in response to TNFα by cleaving polyubiquitin chains from RIP1 which is a component of the TNFR complex ."
23564640
OTUD7B affects p38
| 1
OTUD7B leads to the phosphorylation of p38. 1 / 1
| 1
reach
"In vitro, overexpression of OTUD7B downregulated the phosphorylation level of FAK and then inhibited ERK/P38 phosphorylation, thus leading to decreased α-SMA and collagen Ⅰ expressions, while OTUD7B knockdown showed an opposite result."
35523269
OTUD7B affects noncanonical NF-kappaB
| 1
OTUD7B inhibits noncanonical NF-kappaB. 1 / 1
| 1
eidos
"70 OTUD7B deficiency leads to enhanced noncanonical NF-kappaB activity ."
34977871
OTUD7B affects metastasization
| 1
OTUD7B activates metastasization. 1 / 1
| 1
eidos
"Its increased expression has been reported in lung squamous carcinoma and adenocarcinoma compared to normal tissue ; in the same cancer model , OTUD7B promoted cell proliferation , migration and metastasization [ 45 ] ."
33371395
OTUD7B affects mTORC1
| 1
OTUD7B decreases the amount of mTORC1. 1 / 1
| 1
reach
"Wang et al. [17] demonstrated that OTU deubiquitinase 7B (OTUD7B) reduced ubiquitination level of GβL to prevent GβL from interacting with SIN1, leading to activation of mTORC2/AKT signaling pathway and down-regulation of mTORC1 expression."
32175074
OTUD7B affects inhibitory Sal-miR-1 thrombin-induced VSMC migration Figure 3O adhesion
| 1
OTUD7B inhibits inhibitory Sal-miR-1 thrombin-induced VSMC migration Figure 3O adhesion. 1 / 1
| 1
eidos
"Moreover , OTUD7B inhibition also largely increased the inhibitory effects of Sal-miR-1 and 3 on thrombin-induced VSMC migration ( Figure 3O ) and adhesion ( Figure 3P ) , accompanied by a corresponding change in actin cytoskeleton morphology ( Figure 3N ) and the expression of VCAM-1 and ICAM-1 ( Figure 3M ) ."
32685020
OTUD7B affects inflammation lung
| 1
OTUD7B inhibits inflammation lung. 1 / 1
| 1
eidos
"miR-486-5p not only targets neuropilin 2 ( NRP2 ) encoding inflammatory inhibitor neuropilin-2 , but also represses OTUD7B to induce excessive inflammation in lung 26 , 27 , 28 ( Figure 2F ) ."
| PMC
OTUD7B affects estrogen response element breast cancer cells
| 1
OTUD7B activates estrogen response element breast cancer cells. 1 / 1
| 1
eidos
"Depletion of OTUD7B decreased ERalpha protein level , the expression of ERalpha target genes , and the activity of estrogen response element in breast cancer cells ."
34035221
OTUD7B affects eae
| 1
OTUD7B inhibits eae. 1 / 1
| 1
reach
"Compared with the Otud7b +/+ mice, the Otud7b -/- mice had delayed onset and reduced clinical scores of EAE, suggesting a role for Otud7b in facilitating EAE induction (XREF_FIG)."
26903241
OTUD7B affects deubiquitinase enzyme
| 1
OTUD7B inhibits deubiquitinase enzyme. 1 / 1
| 1
reach
"Of the targets shown in Fig. 1, an inhibitor of the deubiquitinase enzyme (DUB), OTUD7B, could specifically activate the non-canonical NFkB pathway."
34458756
OTUD7B affects degradation
| 1
OTUD7B inhibits degradation. 1 / 1
| 1
sparser
"Otud7b inhibits ubiquitin-dependent Traf3 degradation in B cells stimulated through TNF receptor family members, such as BAFF receptor and CD40, and, thereby, negatively regulates noncanonical NF-κB signaling and B cell activation ( xref )."
26903241
OTUD7B affects cell cycle
| 1
OTUD7B activates cell cycle. 1 / 1
| 1
reach
"Moreover, physiological fluctuation of OTUD7B modulates cell cycle-dependent LSD1 oscillation, ensuring the G1/S transition."
34050636
OTUD7B affects breast cancer cell
| 1
OTUD7B activates breast cancer cell. 1 / 1
| 1
eidos
"OTUD7B stabilizes estrogen receptor alpha and promotes breast cancer cell proliferation ."
34035221
OTUD7B affects autophagy
| 1
OTUD7B inhibits autophagy. 1 / 1
| 1
reach
"In vivo, the overexpression of Cezanne using cardiomyocyte-targeted adeno-associated virus 9 (AAV9) significantly reduced cardiomyocyte apoptosis, autophagy and oxidative stress level when C57BL/6J mice were subjected to DOX."
36639017
OTUD7B inhibits apoptotic process. 1 / 1
| 1
reach
"In vivo, the overexpression of Cezanne using cardiomyocyte-targeted adeno-associated virus 9 (AAV9) significantly reduced cardiomyocyte apoptosis, autophagy and oxidative stress level when C57BL/6J mice were subjected to DOX."
36639017
OTUD7B affects angiogenesis
| 1
OTUD7B activates angiogenesis. 1 / 1
| 1
reach
"ELISA and tube formation assay revealed OTUD7B promotes VEGF production and angiogenesis."
31572671
OTUD7B affects activation non-canonical NF-kappaB pathway
| 1
OTUD7B inhibits activation non-canonical NF-kappaB pathway. 1 / 1
| 1
eidos
"Consistently , OTUD7B ( WT ) but not OTUD7B ( CH ) inhibited activation of the non-canonical NF-kappaB pathway and LCL161-induced lung cancer cell invasion and migration ( Fig. 9 ) ."
33198776
OTUD7B affects ZRANB1
| 1
TRAF6 binds OTUD7B and ZRANB1. 1 / 1
| 1
sparser
"Co-immunoprecipitation studies indicated that TRAF6 was able to interact with both Cezanne and TRABID."
11463333
OTUD7B affects ZDHHC17
1 |
OTUD7B binds ZDHHC17. 1 / 1
1 |
biogrid
No evidence text available
24705354
OTUD7B affects YAP1
| 1
OTUD7B deubiquitinates YAP1. 1 / 1
| 1
reach
"OTUD7B deubiquitinates and stabilizes YAP1 to upregulate NUAK2 expression, thus accelerating gastric cancer procession."
37429790
OTUD7B affects XPO1
1 |
XPO1 binds OTUD7B. 1 / 1
1 |
biogrid
No evidence text available
21888622
OTUD7B affects WWP2
1 |
OTUD7B binds WWP2. 1 / 1
1 |
biogrid
No evidence text available
25071155
OTUD7B affects WWOX
1 |
WWOX binds OTUD7B. 1 / 1
1 |
biogrid
No evidence text available
24550385
OTUD7B affects WIPI1
| 1
OTUD7B binds WIPI1. 1 / 1
| 1
sparser
"An equivalent catalytically inactive mutant of the closely related DUB Cezanne does not form puncta upon overexpression ( xref ), suggesting that the propensity to form dynamic protein assemblies is not a general property of catalytically inactive OTU family proteins."
22157957
OTUD7B affects VCAM1
| 1
OTUD7B inhibits VCAM1. 1 / 1
| 1
reach
"Silencing of Cezanne using a pool of siRNA sequences from an alternative source also significantly enhanced the induction of E-selectin, VCAM-1 and ICAM-1 in EC exposed to hypoxia-reoxygenation (Online Fig. VI)."
23564640
OTUD7B affects USP9X, and ZAP70
| 1
USP9X binds ZAP70 and OTUD7B. 1 / 1
| 1
sparser
"Unlike Otud7b, USP9X does not directly interact with Zap70 but rather comes into the proximity of Zap70 via interaction with a LAT signaling complex [ xref ]."
30054854
OTUD7B affects USP28
| 1
USP28 binds OTUD7B. 1 / 1
| 1
reach
"In addition to USP22 and USP28, ectopic OTUD7B also bound robustly to endogenous LSD1 (Figure  1A )."
34050636
OTUD7B affects USP22
| 1
USP22 binds OTUD7B. 1 / 1
| 1
reach
"In addition to USP22 and USP28, ectopic OTUD7B also bound robustly to endogenous LSD1 (Figure  1A )."
34050636
OTUD7B affects US7
1 |
OTUD7B binds US7. 1 / 1
1 |
virhostnet
No evidence text available
31873071
OTUD7B affects UBE2S
1 |
OTUD7B binds UBE2S. 1 / 1
1 |
biogrid
No evidence text available
20622874
OTUD7B affects UBA1
| 1
UBA1 binds OTUD7B, OTUD7A, and polyubiquitin. 1 / 1
| 1
sparser
"Using a ubiquitin binding domain protein array screen, we identify that the UBA domains of Cezanne and Cezanne2 (also known as Otud7A) selectively bind to Lys63-linked polyubiquitin."
31699778
OTUD7B affects TRAF6, and ZRANB1
| 1
TRAF6 binds OTUD7B and ZRANB1. 1 / 1
| 1
sparser
"Co-immunoprecipitation studies indicated that TRAF6 was able to interact with both Cezanne and TRABID."
11463333
OTUD7B affects TRAF3 proteolysis
| 1
OTUD7B inhibits TRAF3 proteolysis. 1 / 1
| 1
eidos
"Specifically , OTUD7B inhibits TRAF3 proteolysis to prevent aberrant noncanonical NF-kappaB activation by binding and deubiquitinating TRAF312 ."
32826889
OTUD7B affects TAX1BP1
| 1
TAX1BP1 binds OTUD7B and CYLD. 1 / 1
| 1
sparser
"As the inhibitory effect of CYLD, TAX1BP1, and OTUD7B on NF-ĸB activation are associated with deconjugation of K63-polyubiquitin chains from RIP1 [ xref , xref , xref ], we then examined the effect of miR-500 on the ubiquitination status of RIP1."
25595906
reach
"Thus, USP12 and OTUD7B counterbalance inhibitory E3 ligases to stabilize TCR signaling.Aside from acting at the proximal signalosome, E3 ligases also inhibit T-cell activation by acting further downstream, controlling the key transduction events that lead to the nuclear translocation of the T-cell activating transcription factors."
| PMC
OTUD7B affects Sts1/2, and ZAP70
| 1
ZAP70 binds OTUD7B and Sts1/2. 1 / 1
| 1
sparser
"Collectively, these data suggest that the enhanced interaction between Zap70 and Sts1/2 in Otud7b-deficient T cells contributes to attenuated Zap70 activation and TCR signaling."
26903241
OTUD7B affects Ser-Met
| 1
OTUD7B inhibits Ser-Met. 1 / 1
| 1
reach
"Also, Sal-miR-1 and 3 induced upregulation of SMC specific contractile proteins (SM alpha-actin, SM22alpha, calponin and SMMHC), which were suppressed in thrombin treated VSMCs, was largely enhanced by OTUD7B knockdown."
32685020
OTUD7B affects Sal-miR-1 and 3
| 1
OTUD7B inhibits Sal-miR-1 and 3. 1 / 1
| 1
reach
"Moreover, OTUD7B inhibition also largely increased the inhibitory effects of Sal-miR-1 and 3 on thrombin induced VSMC migration and adhesion, accompanied by a corresponding change in actin cytoskeleton morphology and the expression of VCAM-1 and ICAM-1."
32685020
OTUD7B affects Sal-miR-1 3-induced upregulation SMC-specific contractile proteins
| 1
OTUD7B activates Sal-miR-1 3-induced upregulation SMC-specific contractile proteins. 1 / 1
| 1
eidos
"Also , Sal-miR-1 and 3-induced upregulation of SMC-specific contractile proteins ( SM alpha-actin , SM22alpha , calponin and SMMHC ) , which were suppressed in thrombin-treated VSMCs , was largely enhanced by OTUD7B knockdown ( Figure 3M ) ."
32685020
OTUD7B affects SLC9A3R2
1 |
SLC9A3R2 binds OTUD7B. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD7B affects SIRT6
| 1
OTUD7B activates SIRT6. 1 / 1
| 1
eidos
"Inhibiting Cezanne increases the level of SIRT6 that is downregulated in the ischemic neurons ."
34324860
OTUD7B affects SELE
| 1
OTUD7B inhibits SELE. 1 / 1
| 1
reach
"Silencing of Cezanne using a pool of siRNA sequences from an alternative source also significantly enhanced the induction of E-selectin, VCAM-1 and ICAM-1 in EC exposed to hypoxia-reoxygenation (Online Fig. VI)."
23564640
OTUD7B affects S1, and SHBG
| 1
SHBG binds OTUD7B and S1. 1 / 1
| 1
reach
"Furthermore, mutations in the S2 site using K48-linked diUb-AMC substrates showed a drastic reduction in hydrolysis supporting the importance of S2 site binding of distal Ub.A detailed analysis of internal K11-linked diUb ABP binding to Cezanne revealed that recognition of S1 0 site ubiquitin leads to a large dynamic conformational change and subsequent catalysis in Cezanne."
| PMC
OTUD7B affects RELA
| 1
OTUD7B leads to the dephosphorylation of RELA. 1 / 1
| 1
reach
"Cezanne suppresses inflammatory activation in response to hypoxia-reoxygenation by inhibiting RelA phosphorylation."
23564640
OTUD7B affects RCOR1
| 1
OTUD7B binds RCOR1. 1 / 1
| 1
reach
"Notably, we were unable to detect any significant interaction between OTUD7B and CoREST when both were ectopically expressed, even in cells expressing ectopic LSD1 (Figure S1E, Supporting Information)."
34050636
OTUD7B affects PIK3 C3
| 1
OTUD7B inhibits PIK3 C3. 1 / 1
| 1
eidos
"Mechanistically , we demonstrated that STAMBP / AMSH ( STAM-binding protein ) promotes the stabilization of ULK1 by removing its lysine 48 ( K48 ) - linked ubiquitination , whereas OTUD7B mediates the degradation of PIK3 C3 by enhancing its K48-linked ubiquitination , thus positively or negatively affects autophagy flux , respectively ."
32453962
OTUD7B affects PHD-mediated HIF-1alpha hydroxylation
| 1
OTUD7B activates PHD-mediated HIF-1alpha hydroxylation. 1 / 1
| 1
eidos
"Further , the effects of OTUD7B on HIF-1alpha were not dependent on PHD-mediated HIF-1alpha hydroxylation , but required VHL ."
31208103
OTUD7B affects PARK7, and RIPK1
| 1
RIPK1 binds PARK7 and OTUD7B. 1 / 1
| 1
sparser
"Cezanne interacts with DJ-1 and targets RIPK1 signaling intermediates, thereby suppressing NF-κB nuclear translocation and its activity [ xref , xref ]."
32549302
OTUD7B affects P38 MAPK signaling pathway
| 1
OTUD7B activates P38 MAPK signaling pathway. 1 / 1
| 1
eidos
"OTUD7B ( Cezanne ) ameliorates fibrosis after myocardial infarction via FAK-ERK / P38 MAPK signaling pathway ."
35523269
OTUD7B affects OTUD7B
| 1
OTUD7B deubiquitinates OTUD7B. 1 / 1
| 1
reach
"These data indicated that OTUD7B interacts with and deubiquitylates KLF4 and OTUD7B downregulation by Sal-miR-1 and 3 attenuates KLF4 protein levels."
32685020
OTUD7B affects Neoplasms
| 1
OTUD7B activates Neoplasms. 1 / 1
| 1
eidos
"Recent studies suggested that OTUD7B may promote cancer progression by activating oncogenic pathways including EGFR and mTORC2 / Akt signaling [ 62,238 ] ."
| PMC
OTUD7B affects NUP155
1 |
OTUD7B binds NUP155. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD7B affects NIK processing p100
| 1
OTUD7B activates NIK processing p100. 1 / 1
| 1
eidos
"We transfected HA-OTUD7B ( WT ) and HA-OTUD7B ( CH ) into H1299 cells and found that OTUD7B ( CH ) decreased the expression of TRAF3 and led to an increase in NIK and processing of p100 to p52 compared to that in the OTUD7B ( WT ) cells ( Fig. 6b ) ."
33198776
OTUD7B affects NIK NF-kappaB pathways
| 1
OTUD7B inhibits NIK NF-kappaB pathways. 1 / 1
| 1
eidos
"OTUD7B deubiquitinates TRAF3 and inhibits NIK and NF-kappaB pathways to suppress LCL161-induced cell invasion and migration ."
33198776
OTUD7B affects NFKB1
| 1
OTUD7B inhibits NFKB1. 1 / 1
| 1
reach
"Of the targets shown in Fig. 1, an inhibitor of the deubiquitinase enzyme (DUB), OTUD7B, could specifically activate the non-canonical NFkB pathway."
34458756
OTUD7B affects NF-kappaB-Lin28
| 1
OTUD7B inhibits NF-kappaB-Lin28. 1 / 1
| 1
reach
"In silico analysis suggested that OTUD7B regulation, probably owing to miR-1180 downregulation, may negatively regulate the NF-kappaB-Lin28 axis which in turn triggers Let-7 microRNA mediated caspase-3 downregulation, thereby conferring paclitaxel resistance in TNBCs."
29416635
OTUD7B affects NF-kappaB pathway
| 1
OTUD7B inhibits NF-kappaB pathway. 1 / 1
| 1
eidos
"Previous studies have shown that OTUD7B inhibited NF-kappaB pathway by deconjugating K63-polyubiquitin chains from RIP-1 and TRAF6 , suggesting that it may have roles in inhibition of cancer progression 42 , 43 ."
32685020
OTUD7B affects NF-kappaB pathway liver cancer
| 1
OTUD7B inhibits NF-kappaB pathway liver cancer. 1 / 1
| 1
eidos
"A previous study showed that OTUD7B can inhibit the NF-kappaB pathway in liver cancer [ 33 ] ."
33198776
OTUD7B affects NELFCD
| 1
OTUD7B inhibits NELFCD. 1 / 1
| 1
reach
"Compared with Otud7b +/+ mice, the Otud7b -/- mice had reduced frequencies of Th1, but not Th17, cells in both of the spleen and draining LN (XREF_FIG)."
26903241
OTUD7B affects N4BP1
| 1
OTUD7B binds N4BP1. 1 / 1
| 1
sparser
"Besides this, N4BP1 interacts with the deubiquitinase (DUB) Cezanne-1, which functions in the deubiquitination and stabilization of TRAF3 [ xref ] and subsequently modulates the activation of both the canonical [ xref ] and non-canonical NFkB [ xref ] by affecting the degradation of NIK and IkB, and the induction of c-REL ubiquitination and proteasome-mediated degradation [ xref ]."
32630675
OTUD7B affects MYH11
| 1
OTUD7B increases the amount of MYH11. 1 / 1
| 1
reach
"Importantly, OTUD7B downregulation by Sal-miR-1 and 3 results in a reduction in KLF4 protein level, which in turn relieves KLF4 repression of the expression of SM alpha-actin, SM22alpha, and SMMHC, thus facilitating VSMC contractile gene (VSMC differentiation gene) expression."
32685020
OTUD7B affects MYC
| 1
OTUD7B binds MYC. 1 / 1
| 1
sparser
"Myc‐OTUD7B and Myc‐LSD1 were generated by subcloning the corresponding cDNAs into the pCDNA3.1‐Myc expressing vector via BamHI and XhoI sites."
34050636
OTUD7B affects MSH3
1 |
OTUD7B binds MSH3. 1 / 1
1 |
biogrid
No evidence text available
22939629
OTUD7B affects Linc00976
| 1
OTUD7B decreases the amount of Linc00976. 1 / 1
| 1
reach
"qRT-PCR illustrated that miR-137 downregulated promotes the mRNA express level of MAPK target genes (CyclinD1, CDK2, MMP2, MMP9), Linc00976 and OTUD7B downregulating could reverse the effect in Linc00976U PC cells (Fig. 7g)."
31747939
OTUD7B affects LGR4
1 |
LGR4 binds OTUD7B. 1 / 1
1 |
biogrid
No evidence text available
24639526
OTUD7B affects LCL161-induced lung cancer cell metastasis
| 1
OTUD7B inhibits LCL161-induced lung cancer cell metastasis. 1 / 1
| 1
eidos
"* P < 0.05 OTUD7B inhibits LCL161-induced lung cancer cell intrapulmonary metastasis in vivo To confirm that OTUD7B inhibits LCL161-induced lung cancer cell metastasis in vivo , we stably transfected empty vector , HA-OTUD7B ( WT ) and HA-OTUD7B ( CH ) plasmids into H1299 cells ( Fig. 7a ) and implanted the cells into nude mice via caudal vein injection ."
33198776
OTUD7B affects LCL161-induced cell elongation
| 1
OTUD7B inhibits LCL161-induced cell elongation. 1 / 1
| 1
eidos
"* P < 0.05 OTUD7B inhibits NIK to suppress LCL161-induced NF-kappaB pathway activation and cell elongation , invasion and migration To investigate how OTUD7B inhibits LCL161-induced cell elongation , invasion and migration , we established H1299 cells that overexpressed OTUD7B ."
33198776
OTUD7B affects LCL161-induced NF-kappaB pathway
| 1
OTUD7B inhibits LCL161-induced NF-kappaB pathway. 1 / 1
| 1
eidos
"* P < 0.05 OTUD7B deubiquitinates TRAF3 to inhibit NIK To examine the potential mechanism by which OTUD7B inhibits the LCL161-induced NF-kappaB pathway , we transfected Flag-TRAF3 and HA-OTUD7B , Myc-NIK and HA-OTUD7B into H1299 cells for 48 h. Reciprocal co-immunoprecipitation was performed using anti-Flag anti-Myc and anti-HA antibodies to confirm whether OTUD7B directly binds to NIK or TRAF3 ."
33198776
OTUD7B affects LCL161
| 1
OTUD7B inhibits LCL161. 1 / 1
| 1
eidos
"To investigate whether OTUD7B can inhibit LCL161 induced-invasion and metastasis in vivo , four groups of six mice each were administered 5 x 106 cells by intravenous tail vein injections ."
33198776
OTUD7B affects KLF4 proteolysis
| 1
OTUD7B activates KLF4 proteolysis. 1 / 1
| 1
eidos
"However , OTUD7B knockdown or overexpression did not significantly influence KLF4 mRNA level ( Figure 4C-E ) , indicating that OTUD7B regulates KLF4 protein levels through deubiquitinating KLF4 , thereby inhibiting KLF4 proteolysis ."
32685020
OTUD7B affects KLF4 protein clarify
| 1
OTUD7B activates KLF4 protein clarify. 1 / 1
| 1
eidos
"OTUD7B downregulation by Sal-miR-1 and 3 attenuates KLF4 protein levels To clarify which substrate is regulated and deubiquitinated by OTUD7B in the context of VSMC migration and adhesion , we used 3 protein-protein interaction prediction databases ( Cytoscape : http://apps.cytoscape.org/apps/agilentliteraturesearch; inBio-Map : https://www.intomics.com/inbio/map.html#search; Genemania : http://genemania.org ) to search for putative proteins interacting with OTUD7B ."
32685020
OTUD7B affects K63-polyubiquitin chains
| 1
OTUD7B inhibits K63-polyubiquitin chains. 1 / 1
| 1
reach
"Previous studies have shown that OTUD7B inhibited NF-kappaB pathway by deconjugating K63-polyubiquitin chains from RIP-1 and TRAF6, suggesting that it may have roles in inhibition of cancer progression XREF_BIBR, XREF_BIBR."
32685020
OTUD7B affects K63-polyUb
| 1
OTUD7B ubiquitinates K63-polyUb. 1 / 1
| 1
reach
"Similar to A20, Cezanne also was shown to suppress NF-κB signaling by deubiquitinating K63-polyUb from RIPK1 [68,69] and TRAF6 [70]."
31208841
OTUD7B affects IRF3-associated cargo receptor SQSTM1
| 1
OTUD7B activates IRF3-associated cargo receptor SQSTM1. 1 / 1
| 1
eidos
"Mechanistically , OTUD7B interacts with IRF3 , and activates IRF3-associated cargo receptor SQSTM1 / p62 ( sequestosome 1 ) by removing its K63-linked poly-ubiquitin chains at lysine 7 ( K7 ) to enhance SQSTM1 oligomerization ."
35100065
OTUD7B affects IL2
| 1
OTUD7B activates IL2. 1 / 1
| 1
reach
"Indeed, in vitro activated naive Otud7b -/- T cells produced less IL-2, and aged Otud7b deficient mice had increased frequencies and numbers of naive CD4 T cells, whereas those of effector-memory phenotype were decreased."
29685903
OTUD7B affects IGF1R
| 1
OTUD7B binds IGF1R. 1 / 1
| 1
sparser
"Methods: Co-Immunoprecipitation assay was performed to investigate the interactions between Cezanne and IGF-1R. A xenograft model was established to assess the efficacy of Cezanne on cancer progression in vivo."
33415003
OTUD7B affects IFNGR2
| 1
OTUD7B binds ESR1 and IFNGR2. 1 / 1
| 1
sparser
"Additionally, deletion analysis demonstrated that OTUD7B physically interacted with the AF1 domain of ERα (Fig. xref )."
34035221
OTUD7B affects IFNG
| 1
OTUD7B activates IFNG. 1 / 1
| 1
reach
"Additionally, in vitro differentiated Otud7b -/- Th1 cells produced less IFNgamma, a result that was substantiated by in vivo experiments showing that Otud7b -/- mice generated fewer Th1 cells in response to bacterial infection or during myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis."
29685903
OTUD7B affects HIF-1alpha VHL dependent manner independent PHD-mediated prolyl hydroxylation
| 1
OTUD7B activates HIF-1alpha VHL dependent manner independent PHD-mediated prolyl hydroxylation. 1 / 1
| 1
eidos
"Loss of OTUD7B leads to degradation of HIF-1alpha in a VHL dependent manner independent of PHD-mediated prolyl hydroxylation [ 69,82 ] ."
33466790
OTUD7B affects HIF-1alpha HIF-2alpha
| 1
OTUD7B activates HIF-1alpha HIF-2alpha. 1 / 1
| 1
eidos
"However , the knockdown of OTUD7B decreased HIF-1alpha and HIF-2alpha levels and increased K11 linkages on HIF-1alpha , but not K48 linkages ."
31208103
OTUD7B affects H3K9me2
| 1
OTUD7B activates H3K9me2. 1 / 1
| 1
reach
"Importantly, in LSD1‐reconstituted cells, LSD1 rendered their promoters resistant to OTUD7B ablation‐induced H3K4me2/H3K9me2 alterations (Figure 6J,L)."
34050636
OTUD7B affects GβL
| 1
OTUD7B decreases the amount of GβL. 1 / 1
| 1
reach
"Wang et al. [17] demonstrated that OTU deubiquitinase 7B (OTUD7B) reduced ubiquitination level of GβL to prevent GβL from interacting with SIN1, leading to activation of mTORC2/AKT signaling pathway and down-regulation of mTORC1 expression."
32175074
OTUD7B affects GbetaL
| 1
OTUD7B leads to the deubiquitination of GbetaL. 1 / 1
| 1
reach
"Deletion of Otud7b did not significantly affect Akt ubiquitination, but largely abolished the decrease of GbetaL ubiquitination in cells induced by growth factor stimulation (XREF_FIG and XREF_FIG)."
28489822
OTUD7B affects GST
| 1
GST binds OTUD7B. 1 / 1
| 1
sparser
"GST‐OTUD7B and GST‐LSD1 were generated by subcloning the corresponding cDNAs into the pGEX4T1 expressing vector via BamHI and XhoI sites."
34050636
OTUD7B affects Flag
| 1
OTUD7B binds Flag. 1 / 1
| 1
sparser
"Upon H 2 O 2 treatment, we found that exogenously expressed C-terminally epitope-tagged human Cezanne (Cezanne-Flag) was labeled by DCP-Bio1 in cell lysates ( xref ), suggesting that Cezanne was oxidized to the sulfenic acid intermediate in response to oxidative stress."
31072419
OTUD7B affects Fibrosis
| 1
OTUD7B activates Fibrosis. 1 / 1
| 1
eidos
"OTUD7B ( Cezanne ) ameliorates fibrosis after myocardial infarction via FAK-ERK / P38 MAPK signaling pathway ."
35523269
OTUD7B affects F_actin
| 1
OTUD7B activates F_actin. 1 / 1
| 1
reach
"However, Traf6 depletion has a minimal effect on the formation of F-actin microspikes induced by ZA20D1 depletion (XREF_FIG) and ZA20D1 depletion has no effect on the levels of phosphorylation of IKKalpha and beta and IkappaB (XREF_FIG and data not shown)."
22450746
OTUD7B affects ERalpha-positive breast cancer cell
| 1
OTUD7B activates ERalpha-positive breast cancer cell. 1 / 1
| 1
eidos
"In addition , OTUD7B depletion significantly decreased ERalpha-positive breast cancer cell proliferation and migration ."
34035221
OTUD7B affects ERalpha target
| 1
OTUD7B activates ERalpha target. 1 / 1
| 1
eidos
"Depletion of OTUD7B decreased ERalpha protein level , the expression of ERalpha target genes , and the activity of estrogen response element in breast cancer cells ."
34035221
OTUD7B affects ERalpha protein
| 1
OTUD7B activates ERalpha protein. 1 / 1
| 1
eidos
"Depletion of OTUD7B decreased ERalpha protein level , the expression of ERalpha target genes , and the activity of estrogen response element in breast cancer cells ."
34035221
OTUD7B affects EPAS1
| 1
OTUD7B binds EPAS1 and HIF1A. 1 / 1
| 1
sparser
"Finally, despite being inconsistent to its role in the regulation of HIF-1α and HIF-2α, decreased Cezanne expression is associated with the progression and poor prognosis in hepatocellular carcinoma ( xref )."
27014628
OTUD7B affects EGFR and MAPK signaling
| 1
OTUD7B activates EGFR and MAPK signaling. 1 / 1
| 1
reach
"Ultimately, OTUD7B mediates EGFR and MAPK signaling pathway, suggesting that linc00976/miR-137/OTUD7B/EGFR axis may act as a potential biomarker and therapeutic target for PC."
31747939
OTUD7B affects EFGR
| 1
OTUD7B activates EFGR. 1 / 1
| 1
reach
"This prevents miR-137 from binding and suppressing OTUD7B mRNA, resulting in OTUD7B dependent activation of the EFGR and MAPK pathway."
33414429
OTUD7B affects DET1
| 1
OTUD7B binds DET1, CUL4A, and CARD16. 1 / 1
| 1
sparser
"Our results indicate that OTUD7B and CUL4A DET1-COP1 exert opposite roles in regulating Sox2 protein stability at the post-translational level."
30405104
OTUD7B affects Collagen
| 1
OTUD7B decreases the amount of Collagen. 1 / 1
| 1
reach
"In vitro, silencing OTUD7B using small interfering RNA (siRNA) increased α-SMA (smooth muscle actin α) and collagen Ⅰ levels in CFs, whereas the overexpression of OTUD7B using adenovirus decreased their expression."
35523269
OTUD7B affects CoREST
| 1
OTUD7B binds CoREST. 1 / 1
| 1
sparser
"Notably, we were unable to detect any significant interaction between OTUD7B and CoREST when both were ectopically expressed, even in cells expressing ectopic LSD1 (Figure xref , Supporting Information)."
34050636
OTUD7B affects Cardiotoxicity
| 1
reach
"Protective Role of Cezanne in Doxorubicin-induced Cardiotoxicity by inhibiting Autophagy, Apoptosis and Oxidative Stress."
36639017
OTUD7B affects CYLD
| 1
TAX1BP1 binds OTUD7B and CYLD. 1 / 1
| 1
sparser
"As the inhibitory effect of CYLD, TAX1BP1, and OTUD7B on NF-ĸB activation are associated with deconjugation of K63-polyubiquitin chains from RIP1 [ xref , xref , xref ], we then examined the effect of miR-500 on the ubiquitination status of RIP1."
25595906
OTUD7B affects CUL4A
| 1
OTUD7B binds DET1, CUL4A, and CARD16. 1 / 1
| 1
sparser
"Our results indicate that OTUD7B and CUL4A DET1-COP1 exert opposite roles in regulating Sox2 protein stability at the post-translational level."
30405104
OTUD7B affects CDC16
1 |
OTUD7B deubiquitinates CDC16. 1 / 1
1 |
ubibrowser
"Here, we demonstrate that Cezanne/OTUD7B is a cell cycle-regulated DUB that opposes the ubiquitination of APC/C targets."
29973362
OTUD7B affects CD8
| 1
OTUD7B activates CD8. 1 / 1
| 1
reach
"However, at an older age (12 mo old), the Otud7b -/- mice had significantly reduced frequency and absolute numbers of memory like T cells and concomitantly increased frequency and numbers of naive T cells in both CD4 + and CD8 + T cell populations (XREF_FIG)."
26903241
OTUD7B affects CARD16
| 1
OTUD7B binds DET1, CUL4A, and CARD16. 1 / 1
| 1
sparser
"Our results indicate that OTUD7B and CUL4A DET1-COP1 exert opposite roles in regulating Sox2 protein stability at the post-translational level."
30405104
OTUD7B affects Akt-pS473
| 1
OTUD7B activates Akt-pS473. 1 / 1
| 1
reach
"Furthermore, we report in leukemia cells, either genetic depletion or 7Bi-mediated pharmacological inhibition of OTUD7B reduces Akt-pS473 via inhibiting the OTUD7B/GβL signaling axis."
36672466
OTUD7B affects AURKA
1 |
AURKA binds OTUD7B. 1 / 1
1 |
biogrid
No evidence text available
26446837
OTUD7B affects AGO1
1 |
OTUD7B binds AGO1. 1 / 1
1 |
biogrid
No evidence text available
25595906
OTUD7B affects ACAD9
1 |
OTUD7B binds ACAD9. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD7A affects polyubiquitin
| 1
UBA1 binds OTUD7B, OTUD7A, and polyubiquitin. 1 / 1
| 1
sparser
"Using a ubiquitin binding domain protein array screen, we identify that the UBA domains of Cezanne and Cezanne2 (also known as Otud7A) selectively bind to Lys63-linked polyubiquitin."
31699778
NUP155 affects OTUD7B
1 |
OTUD7B binds NUP155. 1 / 1
1 |
biogrid
No evidence text available
19615732
NR2F2 affects OTUD7B
1 |
NR2F2 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:msigdb
No evidence text available
NFkappaB affects OTUD7B
| 1
NFkappaB increases the amount of OTUD7B. 1 / 1
| 1
reach
"We also found that Otud7b expression was induced by the noncanonical NF-kappaB signals (XREF_SUPPLEMENTARY), indicating a negative-feedback function."
23334419
NFE2 affects OTUD7B
1 |
NFE2 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:msigdb
No evidence text available
N4BP1 affects OTUD7B
| 1
OTUD7B binds N4BP1. 1 / 1
| 1
sparser
"Besides this, N4BP1 interacts with the deubiquitinase (DUB) Cezanne-1, which functions in the deubiquitination and stabilization of TRAF3 [ xref ] and subsequently modulates the activation of both the canonical [ xref ] and non-canonical NFkB [ xref ] by affecting the degradation of NIK and IkB, and the induction of c-REL ubiquitination and proteasome-mediated degradation [ xref ]."
32630675
MYC affects OTUD7B
| 1
OTUD7B binds MYC. 1 / 1
| 1
sparser
"Myc‐OTUD7B and Myc‐LSD1 were generated by subcloning the corresponding cDNAs into the pCDNA3.1‐Myc expressing vector via BamHI and XhoI sites."
34050636
MSH3 affects OTUD7B
1 |
OTUD7B binds MSH3. 1 / 1
1 |
biogrid
No evidence text available
22939629
MEF2A affects OTUD7B
1 |
MEF2A decreases the amount of OTUD7B. 1 / 1
1 |
biopax:msigdb
No evidence text available
MAP3K14 affects TRAF3
| 1
TRAF3 binds OTUD7B and MAP3K14. 1 / 1
| 1
sparser
"Reciprocal co-immunoprecipitation was performed using anti-Flag anti-Myc and anti-HA antibodies to confirm whether OTUD7B directly binds to NIK or TRAF3."
33198776
Linc00976 affects OTUD7B
| 1
Linc00976 activates OTUD7B. 1 / 1
| 1
reach
"Linc00976 promotes proliferation, migration and invasion by targeting OTUD7B in PC."
31747939
Linc00976 knockdown affects OTUD7B
| 1
Linc00976 knockdown decreases the amount of OTUD7B. 1 / 1
| 1
reach
"Linc00976 knockdown significantly inhibited the mRNA and protein levels of OTUD7B, while Linc00976U upregulated expression (Fig. 5b–c)."
31747939
LINC00976 affects OTUD7B
| 1
LINC00976 activates OTUD7B. 1 / 1
| 1
reach
"Lei et al. (2019) demonstrated that LINC00976 enhances the proliferation and invasion ability of PDAC cells by interacting with miR-137 and consequently upregulating its target OTUD7B, a mediator of the EGFR and mitogen activated protein kinase (MAPK) signalling pathways XREF_BIBR."
33831655
LINC00518 affects OTUD7B
| 1
LINC00518 decreases the amount of OTUD7B. 1 / 1
| 1
reach
"Based on the miRNA sponge model, the reduced expression of LINGO2, NFIA, OTUD7B, SEC22C, and VAMP3 may be induced by LINC00518 mediated sponging of miRNAs."
33371395
LGR4 affects OTUD7B
1 |
LGR4 binds OTUD7B. 1 / 1
1 |
biogrid
No evidence text available
24639526
IRF3 affects OTUD7B
| 1
OTUD7B binds IRF3. 1 / 1
| 1
sparser
"Mechanistically, OTUD7B interacts with IRF3, and activates IRF3-associated cargo receptor SQSTM1/p62 (sequestosome 1) by removing its K63-linked poly-ubiquitin chains at lysine 7 (K7) to enhance SQSTM1 oligomerization."
35100065
IL6 affects OTUD7B
| 1
IL6 increases the amount of OTUD7B. 1 / 1
| 1
reach
"In MEL270 cells, IL6 treatment increased the expression of LINGO2, OTUD7B, and VAMP3 at both 24 and 48h, NFIA at 48 h and SEC22C at 24 h PT (XREF_FIG, Table S1)."
33371395
IGF1R affects OTUD7B
| 1
OTUD7B binds IGF1R. 1 / 1
| 1
sparser
"Methods: Co-Immunoprecipitation assay was performed to investigate the interactions between Cezanne and IGF-1R. A xenograft model was established to assess the efficacy of Cezanne on cancer progression in vivo."
33415003
IFNGR2 affects OTUD7B
| 1
OTUD7B binds ESR1 and IFNGR2. 1 / 1
| 1
sparser
"Additionally, deletion analysis demonstrated that OTUD7B physically interacted with the AF1 domain of ERα (Fig. xref )."
34035221
HOXA5 affects OTUD7B
1 |
HOXA5 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:msigdb
No evidence text available
HNF4A affects OTUD7B
1 |
HNF4A decreases the amount of OTUD7B. 1 / 1
1 |
biopax:msigdb
No evidence text available
HIF1A affects EPAS1
| 1
OTUD7B binds EPAS1 and HIF1A. 1 / 1
| 1
sparser
"Finally, despite being inconsistent to its role in the regulation of HIF-1α and HIF-2α, decreased Cezanne expression is associated with the progression and poor prognosis in hepatocellular carcinoma ( xref )."
27014628
HIF1 affects OTUD7B
| 1
HIF1 increases the amount of OTUD7B. 1 / 1
| 1
reach
"Activation of HIF1α in response to dimethyloxallyl glycine, desferrioxamine or CoCl did not influence Cezanne expression (Online Fig. III) and silencing of HIF1α or HIF2α did not suppress Cezanne expression in hypoxic EC (Online Fig. IV), indicating that induction of Cezanne by hypoxia is HIF-independent."
23564640
GTF3A affects OTUD7B
1 |
GTF3A decreases the amount of OTUD7B. 1 / 1
1 |
biopax:msigdb
No evidence text available
GST affects OTUD7B
| 1
GST binds OTUD7B. 1 / 1
| 1
sparser
"GST‐OTUD7B and GST‐LSD1 were generated by subcloning the corresponding cDNAs into the pGEX4T1 expressing vector via BamHI and XhoI sites."
34050636
Flag affects OTUD7B
| 1
OTUD7B binds Flag. 1 / 1
| 1
sparser
"Upon H 2 O 2 treatment, we found that exogenously expressed C-terminally epitope-tagged human Cezanne (Cezanne-Flag) was labeled by DCP-Bio1 in cell lysates ( xref ), suggesting that Cezanne was oxidized to the sulfenic acid intermediate in response to oxidative stress."
31072419
FOXC1 affects OTUD7B
1 |
FOXC1 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:msigdb
No evidence text available
Endothelial Cells activates OTUD7B. 1 / 1
| 1
reach
"Studies of cultured endothelial cells (EC) demonstrated that hypoxia (1% oxygen) induced Cezanne via p38 MAP kinase-dependent transcriptional and post- transcriptional mechanisms."
23564640
ESR1 affects IFNGR2, and OTUD7B
| 1
OTUD7B binds ESR1 and IFNGR2. 1 / 1
| 1
sparser
"Additionally, deletion analysis demonstrated that OTUD7B physically interacted with the AF1 domain of ERα (Fig. xref )."
34035221
EPAS1 affects OTUD7B
| 1
OTUD7B binds EPAS1 and HIF1A. 1 / 1
| 1
sparser
"Finally, despite being inconsistent to its role in the regulation of HIF-1α and HIF-2α, decreased Cezanne expression is associated with the progression and poor prognosis in hepatocellular carcinoma ( xref )."
27014628
Drugs, Chinese Herbal increases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
23811387
DOX affects OTUD7B
| 1
DOX activates OTUD7B. 1 / 1
| 1
reach
"Mechanistically, the overexpression of Cezanne significantly reversed the in-activation of the PI3K/AKT/mTOR pathway induced by DOX, while the inhibitors of this pathway abolished the effect of Cezanne, suggesting that the PI3K/AKT/mTOR pathway plays a role in the protective function of Cezanne."
36639017
DET1 affects OTUD7B
| 1
OTUD7B binds DET1, CUL4A, and CARD16. 1 / 1
| 1
sparser
"Our results indicate that OTUD7B and CUL4A DET1-COP1 exert opposite roles in regulating Sox2 protein stability at the post-translational level."
30405104
CoREST affects OTUD7B
| 1
OTUD7B binds CoREST. 1 / 1
| 1
sparser
"Notably, we were unable to detect any significant interaction between OTUD7B and CoREST when both were ectopically expressed, even in cells expressing ectopic LSD1 (Figure xref , Supporting Information)."
34050636
CYLD affects TAX1BP1
| 1
TAX1BP1 binds OTUD7B and CYLD. 1 / 1
| 1
sparser
"As the inhibitory effect of CYLD, TAX1BP1, and OTUD7B on NF-ĸB activation are associated with deconjugation of K63-polyubiquitin chains from RIP1 [ xref , xref , xref ], we then examined the effect of miR-500 on the ubiquitination status of RIP1."
25595906
CUL4A affects OTUD7B
| 1
OTUD7B binds DET1, CUL4A, and CARD16. 1 / 1
| 1
sparser
"Our results indicate that OTUD7B and CUL4A DET1-COP1 exert opposite roles in regulating Sox2 protein stability at the post-translational level."
30405104
CLOCK affects OTUD7B
| 1
CLOCK increases the amount of OTUD7B. 1 / 1
| 1
reach
"Further, Clock knockdown decreased the expression of OTUD7B and A20, 2 early immune response factors acting on the NF-kappaB signaling pathway."
32748687
CART1 affects OTUD7B
1 |
CART1 decreases the amount of OTUD7B. 1 / 1
1 |
biopax:msigdb
No evidence text available
CARD16 affects OTUD7B
| 1
OTUD7B binds DET1, CUL4A, and CARD16. 1 / 1
| 1
sparser
"Our results indicate that OTUD7B and CUL4A DET1-COP1 exert opposite roles in regulating Sox2 protein stability at the post-translational level."
30405104
AURKA affects OTUD7B
1 |
AURKA binds OTUD7B. 1 / 1
1 |
biogrid
No evidence text available
26446837
ATP12A affects OTUD7B
1 |
ATP12A decreases the amount of OTUD7B. 1 / 1
1 |
biopax:msigdb
No evidence text available
AGO1 affects OTUD7B
1 |
OTUD7B binds AGO1. 1 / 1
1 |
biogrid
No evidence text available
25595906
ACAD9 affects OTUD7B
1 |
OTUD7B binds ACAD9. 1 / 1
1 |
biogrid
No evidence text available
19615732
6-propyl-2-thiouracil decreases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
24780913
3,4-methylenedioxymethamphetamine decreases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
26251327
17beta-hydroxy-5alpha-androstan-3-one increases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
29581250
17beta-estradiol affects OTUD7B
1 |
17beta-estradiol increases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
23019147
1,2-dimethylhydrazine increases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
27840820
% oxygen affects OTUD7B
| 1
% oxygen activates OTUD7B. 1 / 1
| 1
eidos
"Methods and Results Studies of cultured endothelial cells ( EC ) demonstrated that hypoxia ( 1 % oxygen ) induced Cezanne via p38 MAP kinase-dependent transcriptional and post - transcriptional mechanisms ."
23564640
2,2',5,5'-tetrachlorobiphenyl decreases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
23829299
ctd
No evidence text available
27291303
2,2',3',4,4',5-hexachlorobiphenyl increases the amount of OTUD7B. 1 / 1
1 |
ctd
No evidence text available
23829299