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OTUD7B inhibits KLF4. 2 / 2

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"Notably, OTUD7B suppressed CH progression by activating AKT signaling cascades and regulating KLF4 (Krüppel‐like factor 4) degradation."

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"3) Third, we show for the first time that KLF4 downregulation elicited by Sal-miR-1 and 3 reduced expression of OTUD7B relieves KLF4 repression of the expression of VSMC differentiation genes (e.g. SM alpha-actin, SM22alpha, calponin and SMMHC) and thus increases their expression levels."

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OTUD7B inhibits KLF4. 2 / 2

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