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Hypoxia activates OTUD7B. 7 / 7
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"There is also evidence showing that hypoxia can induce OTUD7B via a p38 MAPK pathway [ 126 ] and UCHL1 expression involving a HIF-alpha-mediated mechanism [ 144 ] ."
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"Studies of cultured endothelial cells (EC) demonstrated that hypoxia (1% oxygen) induced Cezanne via p38 MAP kinase-dependent transcriptional and post- transcriptional mechanisms."
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"Our finding that Cezanne can be induced by hypoxia in vitro led us to examine the expression of Cezanne in tissues exposed to ischemia in vivo."
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"Activation of HIF1α in response to dimethyloxallyl glycine, desferrioxamine or CoCl did not influence Cezanne expression (Online Fig. III) and silencing of HIF1α or HIF2α did not suppress Cezanne expression in hypoxic EC (Online Fig. IV), indicating that induction of Cezanne by hypoxia is HIF-independent."
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"Hypoxia induces Cezanne via transcriptional and post-transcriptional mechanisms."
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"This level of hypoxia (1% O2) also induced Cezanne in cultured microvascular EC at both the mRNA (Fig. 1C) and protein levels (Online Fig. II)."
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"Methods and Results Studies of cultured endothelial cells ( EC ) demonstrated that hypoxia ( 1 % oxygen ) induced Cezanne via p38 MAP kinase-dependent transcriptional and post - transcriptional mechanisms ."
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