IndraLab

Statements

OTUD7B inhibits TRAF3. 3 / 3
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eidos
"We transfected HA-OTUD7B ( WT ) and HA-OTUD7B ( CH ) into H1299 cells and found that OTUD7B ( CH ) decreased the expression of TRAF3 and led to an increase in NIK and processing of p100 to p52 compared to that in the OTUD7B ( WT ) cells ( Fig. 6b ) ."
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"Because Traf3 deficiency also attenuates TCR signaling, we examined whether Otud7b deficiency promoted the degradation of Traf3 in T cells."
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"The de-ubiquitinating enzyme OTUD7B was also shown recently to potentially negatively regulate NF-kappaB2 (and primary B cell activation) by inhibiting activation induced degradation of TRAF3."
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