IndraLab

Statements

OTUD7B activates EGFR. 3 / 4
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"These results suggested that Cezanne could promote autophagy activation and accelerate the recycling of EGFR, which facilitated Osimertinib resistance."
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"Consistently, compared with the focused distribution of EGFR after a 5 min stimulation, Cezanne OE would induce a more scattered distribution of EGFR after a 15 min stimulation of EGF, indicating that Cezanne could accelerate EGFR recycling (Fig. 7)."
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"Based on these results, Cezanne also accelerates EGFR recycling which may explain the mechanism mediating Cezanne expression and Osimertinib resistance."
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