IndraLab

Statements

OTUD7B activates KRAS. 2 / 2
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"In support of a physiologically pivotal role for OTUD7B in the activation of mTORC2 and AKT signalling, genetic deletion of Otud7b in mice suppresses Akt activation and Kras driven lung tumorigenesis in vivo."
28489822
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"Second, OTUD7B amplifications were identified in a variety of cancers, including lung cancer, and homozygous deletion of Otud7b in the Kras LA2 lung cancer mouse model inhibited KRAS driven lung tumorigenesis 95."
29242641