IndraLab

Statements

OTUD7B inhibits TP53. 3 / 3
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"XREF_FIG, two members of the OTU family, OTU6B and OTUD7B, significantly suppressed the transcriptional activity of p53."
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"Thus, addressing the diminished OTUD7B levels in HCC would notionally restore p53 expression and function whereas targeting OTUD7B could help eliminate the effects of p53 GOF mutants."
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"This verified that silencing OTUD7B and RTKN decreased p53 activity, suggesting that these genes encode p53 pathway enhancers."
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