IndraLab

Statements

OTUD7B activates MAPK. 4 / 4
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"As TRAF3 is dispensable for the activation of canonical NF-kappaB and MAPK signaling OTUD7B does not affect these pathways."
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"Therefore, we hypothesized that OTUD7B may deubiquitinate EGFR and activate downstream pathway MAPK."
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"Ultimately, OTUD7B mediates EGFR and MAPK signaling pathway, suggesting that linc00976/miR-137/OTUD7B/EGFR axis may act as a potential biomarker and therapeutic target for PC."
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"This prevents miR-137 from binding and suppressing OTUD7B mRNA, resulting in OTUD7B dependent activation of the EFGR and MAPK pathway."
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