IndraLab

Statements

OTUD7B activates MAPK. 4 / 4
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"This prevents miR-137 from binding and suppressing OTUD7B mRNA, resulting in OTUD7B dependent activation of the EFGR and MAPK pathway."
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"As TRAF3 is dispensable for the activation of canonical NF-kappaB and MAPK signaling OTUD7B does not affect these pathways."
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"Therefore, we hypothesized that OTUD7B may deubiquitinate EGFR and activate downstream pathway MAPK."
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"DC-specific OTUD7b augments NF-kappaB and MAP kinase signaling by stabilizing TRAF2."
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