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F2 activates OTUD7B. 4 / 4
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"Importantly, when VSMCs were transfected with Sal-miR-1 and 3 and then treated with thrombin, the upregulation of OTUD7B by thrombin was greatly abolished."
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"We first observed that thrombin significantly increased OTUD7B expression both at the protein and mRNA levels in a dose - and time-dependent manner ( Figure 3A-D ) ."
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"In this study, our results showed that Sal-miR-1 and 3 reduced the upregulation of the OTUD7B mRNA and protein induced by thrombin."
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"Importantly , when VSMCs were transfected with Sal-miR-1 and 3 and then treated with thrombin , the upregulation of OTUD7B by thrombin was greatly abolished ( Figure 3E-F ) ."
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