IndraLab

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OTUD7B deubiquitinates EGFR. 6 / 7
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"Pareja et al. found that Cezanne promoted oncogenic signaling by deubiquitinating epidermal growth factor receptor (EGFR) to reduce its degradation in breast cancer( Pareja et al., 2012 )."
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"LINC00976 targets OTUD7B, which deubiquitinates EGFR, thereby activating the MAPK signal [47]."
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"OTUD7B deubiquitinated EGFR and facilitates downstream pathway MAPK."
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"Therefore, we hypothesized that OTUD7B may deubiquitinate EGFR and activate downstream pathway MAPK."
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"Therefore, we found that Linc00976 promoted proliferation and invasion via MAPK pathway, which is activated by OTUD7B mediated EGFR deubiquitination and stability.However, the mechanism of linc00976 regulating OTUD7B expression was still not clear."
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"Ultimately, OTUD7B mediates EGFR deubiquitination and stability and MAPK signaling pathway activation, suggesting that linc00976/miR-137/OTUD7B/EGFR axis may act as a feasible therapeutic target for PC."
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