IndraLab

Statements

OTUD7B deubiquitinates EGFR. 5 / 5
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"OTUD7B deubiquitinated EGFR and facilitates downstream pathway MAPK."
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"Therefore, we hypothesized that OTUD7B may deubiquitinate EGFR and activate downstream pathway MAPK."
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"USP21 and Cezanne or OTUD7B negatively regulate NFκB signaling by deubiquitinating and inactivating RIP1 upon TNF-α?stimulation, providing a feedback loop in the proinflammatory signaling"
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"Ultimately, OTUD7B mediates EGFR deubiquitination and stability and MAPK signaling pathway activation, suggesting that linc00976/miR-137/OTUD7B/EGFR axis may act as a feasible therapeutic target for PC."
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"Therefore, we found that Linc00976 promoted proliferation and invasion via MAPK pathway, which is activated by OTUD7B mediated EGFR deubiquitination and stability.However, the mechanism of linc00976 regulating OTUD7B expression was still not clear."
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