IndraLab

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IL1 activates OTUD7B. 2 / 2
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"Our subsequent studies revealed that Cezanne can be induced by TNFα, IL-1 and functions as an inhibitor of NF-κB, thus forming a negative feedback loop in inflammatory cytokine signalling , and a recent report indicated that Cezanne can also influence non-canonical NF-κB activation ."
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"Given that Cezanne can be modulated by shear stress, TNFα, IL-1 and reactive oxygen species , future studies should address whether these factors influence inflammatory responses to hypoxia-reoxygenation by altering the expression and/or activity of Cezanne."
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