IndraLab

Statements

OTUD7B deubiquitinates ZAP70. 6 / 7
1 | 6
reach
"Otud7b binds to and deubiquitinates Zap70."
26903241
reach
"Importantly, the Otud7b deficiency substantially enhanced the ubiquitination of Zap70 (XREF_FIG), and the Otud7b knockdown in EL4 cells also enhanced the TCR-CD28-stimulated Zap70 ubiquitination (XREF_FIG)."
26903241
reach
"Additional support derived from functional analysis of a Zap-70 deubiquitinating enzyme, Otud7b, that was shown to facilitate Zap-70 activation by deubiquitinating Zap-70, thereby limiting Zap-70—Sts interactions and the Sts-mediated suppression of Zap-70 phosphorylation [31]."
37240179
reach
"86 A DUB, Otud7b, deubiquitinates ZAP70 to prevent its association with Sts1 and Sts2, thereby positively regulating TCR signaling."
33436547
reach
"Otud7b binds to and deubiquitinates Zap70, thereby preventing the interaction of Zap70 with the negative-regulatory phosphatases, Sts1 and Sts2 199 (XREF_FIG)."
27012466
reach
"OTUD7B has been shown to antagonize ZAP70 ubiquitination, which prevents association with STS1 and STS2."
28524749