IndraLab

Statements

OTUD7B inhibits Neoplasm Invasiveness. 5 / 5
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"Depletion of ZA20D1 also reduced SCC invasion, which further suggests that it has additional functions besides antagonising Traf6 (XREF_SUPPLEMENTARY)."
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"OTUD7B inhibits NIK to suppress LCL161-induced NF-kappaB pathway activation and cell elongation , invasion and migration ."
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"However, in hepatocellular carcinoma (HCC), OTUD7B may function as a tumor suppressor, which is evidenced by the fact that OTUD7B knockdown accelerates the migration and invasion of HCC cells in vitro and promotes metastasis in vivo."
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"16 , 17 Molecularly, OTUD7B inhibits LCL161 inhibitor of apoptosis protein antagonist‐induced invasion and migration by binding to and deubiquitinating TRAF3 (tumor necrosis factor receptor‐associated factor 3), thereby inhibiting NIK (NF‐κB‐inducing kinase) and preventing noncanonical NF‐κB activation in lung cancer."
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"* P < 0.05 OTUD7B inhibits NIK to suppress LCL161-induced NF-kappaB pathway activation and cell elongation , invasion and migration To investigate how OTUD7B inhibits LCL161-induced cell elongation , invasion and migration , we established H1299 cells that overexpressed OTUD7B ."
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