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P38 activates OTUD7B. 4 / 4
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"Here we describe a novel form of cross-talk between the NF-κB and MAP kinase pathways where p38-dependent induction of Cezanne during hypoxia suppresses NF-κB activity."
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"We examined the mechanism of Cezanne induction by p38 , which is known to influence gene expression via members of the activating transcription factor ( ATF ) family and also by enhancing mRNA stability25 ."
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"P38 also enhanced the stability of Cezanne transcripts in hypoxic EC as pharmacological inhibition of p38 using SB202190 destabilized Cezanne mRNA in actinomycin D chase experiments (Online Fig. V)."
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"Thus we conclude that p38 induces Cezanne through both transcriptional and post-transcriptional mechanisms."
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