IndraLab

Statements

OTUD7B inhibits activation. 2 / 2
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"In this current issue, Luong et al. report that Cezanne can also inhibit NF-κB-dependent inflammatory activation in response to hypoxia-reoxygenation by reducing TRAF6 K63 polyubiquitination."
23743222
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"Because K11-linked polyubiquitin chains have been identified in the activated TNFR1 complex, these results imply that Cezanne may inhibit TNF-induced NF-κB activation by hydrolyzing K11-linked polyubiquitin chains on substrates present in the TNFR1 complex."
22435550