IndraLab

Statements

OTUD7B inhibits Neoplasm Metastasis. 4 / 4
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"To investigate whether OTUD7B can inhibit LCL161 induced-invasion and metastasis in vivo , four groups of six mice each were administered 5 x 106 cells by intravenous tail vein injections ."
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"However, in hepatocellular carcinoma (HCC), OTUD7B may function as a tumor suppressor, which is evidenced by the fact that OTUD7B knockdown accelerates the migration and invasion of HCC cells in vitro and promotes metastasis in vivo."
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"Furthermore, RNA sequencing and bioinformatic analyses indicated that the absence of OTUD7B suppressed signaling pathways related to cancer progression, metastasis, and metabolism."
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"In ERα-negative breast cancer, silencing OTUD7B inhibits cell migration and invasion in vitro and impairs lung metastasis of cancer cells in vivo by increasing lysine-specific demethylase 1 (LSD1)-Ub and targeting LSD1 for p62-mediated proteolysis (16)."
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