IndraLab

Statements

OTUD7B inhibits ZAP70. 3 / 3
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"Otud7b deficiency attenuates the activation of Zap70 and its downstream pathways and impairs T cell activation and differentiation, rendering mice refractory to T cell mediated autoimmune and inflammatory responses."
26903241
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"Otud7b knockdown in EL4 cells also enhanced the inducible association of Zap70 with Sts1/2 (XREF_FIG)."
26903241
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"Otud7b deficiency attenuated TCR-CD28-stimulated activation of Zap70 and downstream signaling factors and impaired T cell activation and Th1 cell differentiation."
26903241