IndraLab

Statements

OTUD7B activates KLF4. 4 / 4
| 4
reach
"Additional molecular experiments showed that OTUD7B impedes KLF4 degradation by inhibiting lysine residue at 48 site-linked ubiquitination and suppressing myocardial hypertrophy by activating the serine/threonine kinase pathway."
38084712
reach
"Correspondingly, OTUD7B knockdown decreased, whereas its overexpression increased, KLF4 protein levels."
32685020
reach
"Our findings reveal, for the first time, that OTUD7B upregulates the level of KLF4 protein through interacting with and deubiquitylating KLF4."
32685020
reach
"Consistently, in HEK293 cells and VSMCs enforced to express OTUD7B and KLF4, OTUD7B overexpression obviously enhanced KLF4 protein stability."
32685020