IndraLab

Statements

MiR-500 inhibits OTUD7B. 3 / 3
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"In gastric cancer cell lines, miR-500 directly repressed CYLD, OTUD7B, and the A20 complex component TAX1BP1 which led to sustained NF-kappaB activation [XREF_BIBR]."
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"Taken together, our results suggest that miR-500 overexpression activates the NF-kappaB signalling pathway by repressing CYLD, TAX1BP1, and OTUD7B, and consequently results in gastric cancer aggressiveness and poor clinical outcomes."
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"Notably, miR-500 also activates NF-κB signaling by directly repressing two other negative regulators of NF-κB, OTUD7B, and TAX1BP1 [69]."
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