IndraLab

Statements

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"OTUD7B interacts with, deubiquitylate, stabilizes estrogen receptor α in a deubiquitylation activity-dependent manner, and promotes breast cancer cell proliferation, resulting in poor prognosis [17]."
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"OTUD7B is associated with poor prognosis and promotes cell proliferation in cancer."
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"Chen et al. reported that OTUD7B promotes proliferation, migration, and invasion by stabilizing N1ICD in pancreatic cancer [20]."
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"OTUD7B stabilizes estrogen receptor alpha and promotes breast cancer cell proliferation."
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"Its increased expression has been reported in lung squamous carcinoma and adenocarcinoma compared to normal tissue; in the same cancer model, OTUD7B promoted cell proliferation, migration and metastasization [XREF_BIBR]."
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"These findings lead us to suggest that the role of OTUD7B in prostate cancer cells may be linked to autophagy through the modulation of the mTOR signaling pathway.Collectively, our current study demonstrated that OTUD7B knockdown inhibits autophagy through activating AKT/mTOR pathway and positively contributes to the extrinsic apoptosis and proliferation of prostate cancer cell."
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"Consistent with an oncogenic role of OTUD7B in facilitating leukemia cell proliferation, inhibiting OTUD7B by 7Bi reduced the proliferation of HL60 (Figure 4L), K562 (Figure 4M) and THP1 (Figure 4N) cells."
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"The authors demonstrated that Cezanne silencing reverts DJ-1 knockdown-induced proliferation inhibition."
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"OTUD7B knockdown inhibits the proliferation and stemness of breast cancer cells by destabilizing FOXM1."
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"The results of Cell Counting Kit 8, colony formation and tumor sphere formation experiments showed that OTUD7B knockdown caused a significant decrease in the proliferation and sphere formation ability of MDA-MB-468, MDA-MB-453 and MCF7 cells in vitro."
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"Cezanne also promotes the proliferation of LUAD cells by stabilizing IGF-1R [16]."
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"32 OTUD7B and MINDY1 could promote breast cancer proliferation by stabilizing ERα in a deubiquitylation activity–dependent manner."
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"In addition, overexpression of OTUD7B promoted cell proliferation, migration, and VM, similar to the effects of an inhibitor of miR-491-5p."
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"The present study demonstrates that linc00976 enhances the proliferation and invasion ability of PC cells by upregulating OTUD7B expression, which was a target of miR-137."
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"Recently, OTUD7B and Cezannehas been reported to deubiquitinate and stabilize the APC/C substrates, as well as promote mitotic progression and cell proliferation."
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"These findings indicated that OTUD7B knockdown reduced the proliferation and stemness of breast cancer cells."
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"These findings collectively identified OTUD7B as an independent predictive factor for the prognosis of non small cell lung cancer and revealed OTUD7B promotes lung cancer cell proliferation and metastasis via Akt and VEGF signal pathway."
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"In ERα-positive breast cancer, OTUD7B deubiquitylates ERα, leading to its stabilization; through this mechanism, OTUD7B promotes the proliferation of breast cancer cells (15)."
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"OTUD7B knockdown reduces the stemness and proliferation of MDA-MB-468 cells."
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"OTUD7B knockdown inhibits proliferation and autophagy through AKT/mTOR signaling pathway in human prostate cancer cell."
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"FOXM1 overexpression rescues the OTUD7B knockdown-induced inhibition of stemness and proliferation in breast cancer cells."
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"As shown in Fig. 7A-C, OTUD7B knockdown inhibited the proliferation of MDA-MB-468, MDA-MB-453 and MCF-7 cells, whereas the overexpression of FOXM1 blocked the inhibitory effect induced by OTUD7B knockdown."
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"Taken together, OTUD7B promotes the proliferation, and autophagy, and inhibits apoptosis of prostate cancer cells via the AKT/mTOR signaling pathway."
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"OTUD7B knockdown inhibits cell proliferation and induces apoptosis in PC3 cells."
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"19 Furthermore, OTUD7B stabilizes estrogen receptor‐α and promotes breast cancer cell proliferation."
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"Its increased expression has been reported in lung squamous carcinoma and adenocarcinoma compared to normal tissue ; in the same cancer model , OTUD7B promoted cell proliferation , migration and metastasization [ 45 ] ."
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"The cell viability assay results showed that OTUD7B knockdown significantly gradually decreased cell proliferation over time compared to negative control cells (Fig. 2B)."
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