IndraLab

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OTUD7B leads to the ubiquitination of KDM1A. 2 / 2

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"In cells expressing K63R Ub mutant, OTUD7B‐depletion failed to increase LSD1 ubiquitination (Figure 2C)."

34050636

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reach

"Collectively, these results demonstrate that K63‐linked ubiquitination of LSD1, triggered by depletion of OTUD7B or CoREST, targets LSD1 to proteasomal degradation via p62.The enhanced interaction between p62 and LSD1 upon OTUD7B loss raised one possibility that p62 may compete with CoREST for binding to ubiquitinated LSD1."

34050636

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IndraLab

Statements

OTUD7B leads to the ubiquitination of KDM1A. 2 / 2

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