IndraLab

Statements

OTUD7B activates AKT. 2 / 3
| 2
reach
"OTUD7B mediated cleavage of K63 linked polyubiquitin chains on GbetaL appears to be a common mechanism to promote mTORC2 and AKT signalling, as knockdown of OTUD7B downregulated AKT (pS473) and conferred chemosensitivity to cancer cells with elevated mTORC2 and AKT signalling due to oncogenic events such as PTEN deletion, PIK3CA, EGFR or KRAS mutations (XREF_FIG)."
28489822
reach
"In support of a physiologically pivotal role for OTUD7B in the activation of mTORC2 and AKT signalling, genetic deletion of Otud7b in mice suppresses Akt activation and Kras driven lung tumorigenesis in vivo."
28489822