IndraLab

Statements

OTUD7B activates AKT. 7 / 8
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"OTUD7B mediated cleavage of K63 linked polyubiquitin chains on GbetaL appears to be a common mechanism to promote mTORC2 and AKT signalling, as knockdown of OTUD7B downregulated AKT (pS473) and conferred chemosensitivity to cancer cells with elevated mTORC2 and AKT signalling due to oncogenic events such as PTEN deletion, PIK3CA, EGFR or KRAS mutations (XREF_FIG)."
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"Bin Wang et al. reported that genetic deletion of Cezanne in mice suppressed AKT activation in vivo , suggesting that Cezanne might activate AKT to protect cell survival( Wang et al., 2017 )."
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"Overall, our results suggest that OTUD7B knockdown reduces autophagy by activating AKT/mTOR signaling in PC3 cells."
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"We found that Cezanne overexpression in NRCMs activated AKT/mTOR to reduce apoptosis, autophagy and oxidative stress; this mechanism of Cezanne was also verified in animal experiments."
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"Bin Wang et al. reported that genetic deletion of Cezanne in mice suppressed AKT activation in vivo , suggesting that Cezanne might activate AKT to protect cell survival( Wang et al., 2017 )."
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"In support of a physiologically pivotal role for OTUD7B in the activation of mTORC2 and AKT signalling, genetic deletion of Otud7b in mice suppresses Akt activation and Kras driven lung tumorigenesis in vivo."
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"To identify the underlying mechanism, we speculated that OTUD7B knockdown inhibits autophagy via the AKT/mTOR signaling pathway in PCa cells."
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