IndraLab

Statements

OTUD7B activates KLF4 protein. 5 / 5
| 5
eidos
"We show here that OTUB7B upregulates the level of KLF4 protein , a stem cell pluripotency protein 41 , through interacting with and deubiquitylating KLF4 , a repressor of VSMC differentiation , whereas OTUD7B downregulation by Sal-miR-1 and 3 attenuates KLF4 protein level ."
32685020
eidos
"Further , using loss - and gain-of-function experiments , we confirmed that knockdown of OTUD7B attenuated KLF4 protein levels , whereas the overexpression of OTUD7B had the opposite effect ."
32685020
eidos
"Most importantly , OTUD7B downregulation by Sal-miR-1 and 3 attenuates KLF4 protein levels via decreasing its deubiquitylation , whereas decreased KLF4 relieves its repression of transcription of NMHC IIA gene and thus increases NMHC IIA expression levels ."
32685020
eidos
"Our findings reveal , for the first time , that OTUD7B upregulates the level of KLF4 protein through interacting with and deubiquitylating KLF4 ."
32685020
eidos
"KLF4 negatively regulates NMHC IIA expression , and downregulation of KLF4 by Sal-miR-1 and 3 reduces KLF4 repression of the expression of NMHC IIA and thus increases NMHC IIA expression level Because Sal-miR-1 and 3 downregulated KLF4 protein levels by attenuating OTUD7B expression , we sought to determine KLF4 target genes associated with induction of VSMC migration ."
32685020