IndraLab

Statements

OTUD7B inhibits migration. 7 / 7
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"OTUD7B suppresses Smac mimetic-induced lung cancer cell invasion and migration via deubiquitinating TRAF3 ."
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"However , whether OTUD7B can inhibit LCL161-induced invasion and migration and be used to select a target population in LCL161 treatment for lung cancer is unclear ."
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"OTUD7B inhibits NIK to suppress LCL161-induced NF-kappaB pathway activation and cell elongation , invasion and migration ."
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"Furthermore , OTUD7B can inhibit LCL161-induced lung cancer cell invasion and migration by deubiquitinating TRAF3 , inhibiting NIK and preventing non-canonical NF-kappaB activation ."
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"* P < 0.05 OTUD7B inhibits NIK to suppress LCL161-induced NF-kappaB pathway activation and cell elongation , invasion and migration To investigate how OTUD7B inhibits LCL161-induced cell elongation , invasion and migration , we established H1299 cells that overexpressed OTUD7B ."
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"Moreover , OTUD7B inhibits LCL161-induced invasion and migration by binding to and deubiquitinating TRAF3 , thereby inhibiting NIK and preventing non-canonical NF-kappaB activation ."
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"OTUD7B suppresses Smac mimetic-induced lung cancer cell invasion and migration via deubiquitinating TRAF3 Background Smac mimetics are a type of drug that can induce apoptosis by antagonizing IAP family members in cancer treatment ."
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