IndraLab

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OTUD7B activates KDM1A. 4 / 4
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"Moreover, physiological fluctuation of OTUD7B modulates cell cycle-dependent LSD1 oscillation, ensuring the G1/S transition."
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"We first asked if CoREST is required for OTUD7B‐mediated LSD1 stabilization."
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"The fact that many of these gene hits are linked to cell cycle likely explains the result that the primary functions of OTUD7B or LSD1 in coordinating cell cycle progression.The above ChIP‐seq and RNA‐seq datasets were aligned to explore the potential correlations between OTUD7B‐induced H3K4me2 and LSD1 occupancy changes and changes in gene transcription."
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"19 Strikingly, p62 knockdown completely blunted LSD1 degradation triggered by OTUD7B or CoREST loss (Figure  4A ,B)."
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