IndraLab

Statements

OTUD7B activates Neoplasm Metastasis. 7 / 7
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"These findings collectively identified OTUD7B as an independent predictive factor for the prognosis of non small cell lung cancer and revealed OTUD7B promotes lung cancer cell proliferation and metastasis via Akt and VEGF signal pathway."
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"Strikingly, the OTUD7B defect promoted the association of LSD1 with p62 and targeted LSD1 for p62-mediated proteasomal degradation, thereby eliminating breast cancer metastasis."
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"In ERα-negative breast cancer, silencing OTUD7B markedly inhibits the migration and invasion of cancer cells in vitro, and significantly impairs lung metastasis in vivo (16)."
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"Knockdown of either OTUD7B or LSD1 significantly reduced the expression of metastasis-associated genes and effectively suppressed the metastasis of breast cancer cells."
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"Mechanistically, OTUD7B likely promotes GC metastasis through the WNT signaling pathway, specifically targeting β-catenin."
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"OTUD7B serves as a novel marker for poor prognosis in GC and actively promotes tumor metastasis."
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"These results highlight a pivotal role of OTUD7B‐mediated deubiquitination of LSD1 in modulating its genomic occupancy and the regulation of gene transcription.2.7 OTUD7B Promotes Metastasis via LSD1."
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