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"It was reported that Lys11 modified APC/C substrates are targeted for proteasomal degradation XREF_BIBR, XREF_BIBR, but surprisingly, inhibition of the proteasome by MG132 or epoxomicin, which efficiently stabilised HIF-1alpha protein levels, did not rescue the effect of Cezanne knockdown on HIF-1alpha (Fig XREF_FIG B, Supplementary Fig S4A and C)."