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OTUD7B inhibits PIK3 C3. 1 / 1

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"Mechanistically , we demonstrated that STAMBP / AMSH ( STAM-binding protein ) promotes the stabilization of ULK1 by removing its lysine 48 ( K48 ) - linked ubiquitination , whereas OTUD7B mediates the degradation of PIK3 C3 by enhancing its K48-linked ubiquitination , thus positively or negatively affects autophagy flux , respectively ."

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IndraLab

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OTUD7B inhibits PIK3 C3. 1 / 1

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