IndraLab

Statements

OTUD7B deubiquitinates TRAF3. 3 / 4
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reach
"Accumulation of NIK induces phosphorylation of the inhibitor of kappa-B kinase α (IKKα), leading to the ubiquitination and processing of p100.19 20 21 56 The inactive precursor protein p100 undergoes proteasome-mediated processing to generate active protein p52, which binds to RelB and translocates to the nucleus.19 20 21 The deubiquitination of TRAF3 by Otud7b inhibits NF-κB activation by preventing TRAF3 proteolysis and NIK accumulation.56 Alternatively, the canonical pathway relies on ubiquitination of RIP1 kinase or TRAF6."
38510130
reach
"In response to noncanonical NF-kappaB stimuli, Otud7b binds and deubiquitinates TRAF3, thereby inhibiting TRAF3 proteolysis and preventing aberrant noncanonical NF-kappaB activation."
23334419
trips
"OTUD7B suppresses Smac mimetic-induced lung cancer cell invasion and migration via deubiquitinating TRAF3."
33198776