IndraLab

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OTUD7B activates TRAF3. 6 / 8
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"In addition to being transcriptionally upregulated by NF-kappaB to promote NIK degradation, leading to p100 stabilization and attenuation of non canonical NF-kappaB signalling, TRAF3 is subject to post-translational stabilisation by means of OTUD7B, which targets TRAF3 for deubiquitination of its K48 linked polyubiquitin chains, thereby preventing NIK accumulation and the processing of p100 [XREF_BIBR, XREF_BIBR]."
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"Otud7b inhibits ubiquitin dependent Traf3 degradation in B cells stimulated through TNF receptor family members, such as BAFF receptor and CD40, and, thereby, negatively regulates noncanonical NF-kappaB signaling and B cell activation."
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"Interestingly , we discovered that OTUD7B increases TRAF3 and decreases NIK to inhibit the non-canonical NF-kappaB pathway and that overexpression of OTUD7B suppresses LCL161-induced cell invasion and migration ."
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"Although the OTU domain of Otud7b preferentially cleaves K11 linked ubiquitin chains in vitro, the Otud7b deficiency in vivo promotes TRAF3 conjugation with K48 ubiquitin chains."
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"OTUD7B increased expression of TRAF3 , leading to a decrease in NIK and processing of p100 to p52 compared to those in the empty vector group ( Fig. 4c ) ."
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"Likely candidate genes include those encoding TRAF2, TRAF3, the cIAPs or OTUD7B, a de-ubiquitinase that promotes TRAF3 stability."
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