IndraLab

Statements

OTUD7B inhibits RNF8. 4 / 4
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"This is consistent with our previous finding that Cezanne antagonizes RNF8 and Ube2S-dependent K11-conjugation on damaged chromatin (Paul and Wang 2017)."
31699778
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"In response to DSB, Cezanne antagonizes the activity of RNF8 and UBE2S [146] ."
34895814
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"To confirm that RNF8 promotes Lys11-linkage ubiquitin modification, we examined whether Cezanne, a DUB that specifically cleaves the Lys11-linkage ubiquitin conjugates, antagonizes the activity of RNF8 in Lys11-linkage ubiquitin modification of chromatin bound proteins."
28525740
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"In response to DSBs, Cezanne antagonizes the activity of RNF8 and Ube2S in K11-linkage ubiquitin modification of chromatin-bound proteins, including H2A/H2AX, on damaged chromatin (Paul and Wang 2017)."
31699778