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OTUD7B inhibits TCR. 2 / 2

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"In T cells, OTUD7B inhibits TCR and CD28-mediated activation by regulating the non-degradative ubiquitination of ZAP70, a central molecule in proximal TCR signaling xref ."

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"Otud7b deficiency attenuated but did not completely block TCR signaling, consistent with partially impaired T cell activation and recall responses."

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IndraLab

Statements

OTUD7B inhibits TCR. 2 / 2

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