IndraLab

Statements

OTUD7B activates HIF1A. 4 / 9
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"Our data suggest that Cezanne is essential for HIF-1alpha protein stability and that loss of Cezanne stimulates HIF-1alpha degradation via proteasome independent routes, possibly through chaperone mediated autophagy."
25355043
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"Overall, these results imply that loss of Cezanne promotes degradation of HIF-1alpha in a proteasome independent manner."
25355043
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"Together, these data suggest that Cezanne does not impact solely on proteasomal degradation of HIF-1alpha, and raise the general question whether the canonical HIF-1alpha degradation machinery is required for Cezanne mediated HIF-1alpha downregulation."
25355043
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"OTUD7B, also known as Cezanne, deubiquitinates Lys11 linked Ub chains and rescues HIF-1alpha from lysosomal degradation."
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