IndraLab

Statements

OTUD7B binds ZAP70. 11 / 11
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"This ubiquitination-defective Zap70 mutant was also attenuated in association with Otud7b, consistent with the idea that the Zap70–Otud7b interaction might be facilitated by Zap70 ubiquitination ( xref )."
26903241
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"In response to TCR-CD28 ligation, Otud7b rapidly bound to Zap70 and inhibited Zap70 ubiquitination."
26903241
reach
"Otud7b binds to and deubiquitinates Zap70."
26903241
reach
"The Otud7b-Zap70 interaction was further confirmed using a transient transfection experiment in which the overexpressed Otud7b strongly associated with Zap70 (XREF_FIG)."
26903241
sparser
"In response to TCR signaling, Otud7b was rapidly recruited to Zap70 via a mechanism that required the UBA domain of Otud7b, suggesting the possibility that Otud7b interacted with ubiquitinated Zap70."
26903241
reach
"Otud7b binds to and deubiquitinates Zap70, thereby preventing the interaction of Zap70 with the negative-regulatory phosphatases, Sts1 and Sts2 199 (XREF_FIG)."
27012466
sparser
"In response to TCR–CD28 ligation, Otud7b rapidly bound to Zap70 and inhibited Zap70 ubiquitination."
26903241
sparser
"Interestingly, although Otud7b did not bind Zap70 in resting T cells, these two proteins formed a complex upon TCR–CD28 stimulation ( xref )."
26903241
sparser
"The Otud7b–Zap70 interaction was further confirmed using a transient transfection experiment in which the overexpressed Otud7b strongly associated with Zap70 ( xref )."
26903241
sparser
"Domain mapping analyses revealed the requirement of the N-terminal UBA domain of Otud7b for its physical interaction with Zap70 ( xref ), indicating the facilitation of Otud7b–Zap70 interaction by ubiquitination."
26903241
sparser
"Upon TCR stimulation, OTUD7B binds to and deubiquitinates Zap70, thereby preventing the binding of Sts1 and 2 [ xref ]."
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