IndraLab

Statements



sparser
"DUB linkage specificity relies on careful positioning of the proximal Ub, which interacts with Cezanne via an unusual surface, involving Thr12, Glu16 and its α-helix (Asp32, Lys33, Glu34, Gly35) ( xref , xref )."

sparser
"Cezanne is hydroxylated at Asn35 of the UBA domain in an oxygen- or FIH1-dependent manner, which inhibits the binding of Ub to Cezanne ( xref )."