IndraLab

Statements

sparser
"Cezanne is hydroxylated at Asn35 of the UBA domain in an oxygen- or FIH1-dependent manner, which inhibits the binding of Ub to Cezanne ( xref )."
34177595
sparser
"Upon binding of the proximal ubiquitin, the prereactive conformation and active state are reached via strong electrostatic interactions between the Cezanne-1 residue Glu157 and Lys33 of PRO ubiquitin."
36943332
sparser
"Downstream of RNF8/RNF168, the DUB Cezanne in complex with Cezanne2 binds to K63-linked ubiquitin chains at the sites of damage and removes K11-linked ubiquitination from mixed polyUb chains as well."
35865631
sparser
"DUB linkage specificity relies on careful positioning of the proximal Ub, which interacts with Cezanne via an unusual surface, involving Thr12, Glu16 and its α-helix (Asp32, Lys33, Glu34, Gly35) ( xref , xref )."
27732584
sparser
"The strong electrostatic interaction between the Cezanne-1 residue Glu157 and Lys33 of PRO ubiquitin is persistent and stabilizes the substrate positioning relative to the catalytic residues."
36943332