IndraLab

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OTUD7B decreases the amount of KLF4. 3 / 3
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"OTUD7B downregulation by Sal-miR-1 and 3 attenuates KLF4 protein levels."
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"We show here that OTUB7B upregulates the level of KLF4 protein, a stem cell pluripotency protein XREF_BIBR, through interacting with and deubiquitylating KLF4, a repressor of VSMC differentiation, whereas OTUD7B downregulation by Sal-miR-1 and 3 attenuates KLF4 protein level."
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"Most importantly, OTUD7B downregulation by Sal-miR-1 and 3 attenuates KLF4 protein levels via decreasing its deubiquitylation, whereas decreased KLF4 relieves its repression of transcription of NMHC IIA gene and thus increases NMHC IIA expression levels."
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