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OTUD7B activates Akt-pS473. 2 / 2

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"More importantly, pharmacological inhibition of OTUD7B by 7Bi reduced Akt-pS473 signals in HL60 (Figure 4H), K562 (Figure 4I) and THP1 (Figure 4J) cells, mimicking the effects of OTUD7B depletion."

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"Furthermore, we report in leukemia cells, either genetic depletion or 7Bi-mediated pharmacological inhibition of OTUD7B reduces Akt-pS473 via inhibiting the OTUD7B/GbetaL signaling axis."

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OTUD7B activates Akt-pS473. 2 / 2

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